4ZNN
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![BU of 4znn by Molmil](/molmil-images/mine/4znn) | MicroED structure of the segment, GVVHGVTTVA, from the A53T familial mutant of Parkinson's disease protein, alpha-synuclein residues 47-56 | Descriptor: | Alpha-synuclein | Authors: | Rodriguez, J.A, Ivanova, M, Sawaya, M.R, Cascio, D, Reyes, F, Shi, D, Johnson, L, Guenther, E, Sangwan, S, Hattne, J, Nannenga, B, Brewster, A.S, Messerschmidt, M, Boutet, S, Sauter, N.K, Gonen, T, Eisenberg, D.S. | Deposit date: | 2015-05-05 | Release date: | 2015-09-09 | Last modified: | 2024-03-06 | Method: | ELECTRON CRYSTALLOGRAPHY (1.41 Å) | Cite: | Structure of the toxic core of alpha-synuclein from invisible crystals. Nature, 525, 2015
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5WOR
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![BU of 5wor by Molmil](/molmil-images/mine/5wor) | |
5WMJ
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![BU of 5wmj by Molmil](/molmil-images/mine/5wmj) | |
5ACM
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![BU of 5acm by Molmil](/molmil-images/mine/5acm) | Mcg immunoglobulin variable domain with methylene blue | Descriptor: | 3,7-BIS(DIMETHYLAMINO)PHENOTHIAZIN-5-IUM, GLYCEROL, MCG, ... | Authors: | Brumshtein, B, Esswein, S.R, Salwinski, L, Phillips, M.L, Ly, A.T, Cascio, D, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2015-08-17 | Release date: | 2015-12-02 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain. Elife, 4, 2015
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6E75
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![BU of 6e75 by Molmil](/molmil-images/mine/6e75) | Structure of Human Transthyretin Asp38Ala Mutant | Descriptor: | ACETATE ION, Transthyretin | Authors: | Chung, K, Saelices, L, Sawaya, M.R, Cascio, D, Eisenberg, D. | Deposit date: | 2018-07-25 | Release date: | 2019-07-31 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural Variants of Transthyretin To Be Published
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6E6Z
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![BU of 6e6z by Molmil](/molmil-images/mine/6e6z) | Structure of Wild Type Human Transthyretin in Complex with Tafamidis | Descriptor: | 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid, Transthyretin | Authors: | Chung, K, Saelices, L, Sawaya, M.R, Cascio, D, Eisenberg, D. | Deposit date: | 2018-07-25 | Release date: | 2019-07-31 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural Variants of Transthyretin To Be Published
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6E77
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![BU of 6e77 by Molmil](/molmil-images/mine/6e77) | Structure of Human Transthyretin Asp38Ala Mutant in Complex with Tafamidis | Descriptor: | 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid, Transthyretin | Authors: | Saelices, L, Chung, K, Sawaya, M.R, Cascio, D, Eisenberg, D. | Deposit date: | 2018-07-25 | Release date: | 2019-07-31 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural Variants of Transthyretin To Be Published
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6E74
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![BU of 6e74 by Molmil](/molmil-images/mine/6e74) | Structure of Human Transthyretin Leu55Pro Mutant in Complex with Tafamidis | Descriptor: | 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid, Transthyretin | Authors: | Saelices, L, Chung, K, Sawaya, M.R, Cascio, D, Eisenberg, D. | Deposit date: | 2018-07-25 | Release date: | 2019-07-31 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural Variants of Transthyretin To Be Published
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6E70
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![BU of 6e70 by Molmil](/molmil-images/mine/6e70) | Structure of Wild Type Human Transthyretin in Complex with Diflunisal | Descriptor: | 5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC ACID, CALCIUM ION, Transthyretin | Authors: | Chung, K, Saelices, L, Sawaya, M.R, Cascio, D, Eisenberg, D. | Deposit date: | 2018-07-25 | Release date: | 2019-07-31 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.992 Å) | Cite: | Structural Variants of Transthyretin To Be Published
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6E73
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![BU of 6e73 by Molmil](/molmil-images/mine/6e73) | Structure of Human Transthyretin Val30Met Mutant in Complex with Diflunisal | Descriptor: | 5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC ACID, ACETATE ION, Transthyretin | Authors: | Chung, K, Saelices, L, Sawaya, M.R, Cascio, D, Eisenberg, D.S. | Deposit date: | 2018-07-25 | Release date: | 2019-07-31 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.797 Å) | Cite: | Structural Variants of Transthyretin to be published
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6E76
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![BU of 6e76 by Molmil](/molmil-images/mine/6e76) | Structure of Human Transthyretin Asp38Ala/Thr119Met Mutant | Descriptor: | ACETATE ION, GLYCEROL, SULFATE ION, ... | Authors: | Saelices, L, Chung, K, Sawaya, M.R, Cascio, D, Eisenberg, D. | Deposit date: | 2018-07-25 | Release date: | 2019-07-31 | Last modified: | 2019-12-18 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural Variants of Transthyretin To Be Published
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6E72
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![BU of 6e72 by Molmil](/molmil-images/mine/6e72) | Structure of Human Transthyretin Val30Met Mutant in Complex with Tafamidis | Descriptor: | 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid, Transthyretin | Authors: | Chung, K, Saelices, L, Sawaya, M.R, Cascio, D, Eisenberg, D. | Deposit date: | 2018-07-25 | Release date: | 2019-07-31 | Last modified: | 2019-12-18 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Structural Variants of Transthyretin To Be Published
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6E71
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![BU of 6e71 by Molmil](/molmil-images/mine/6e71) | Structure of Human Transthyretin Val30Met/Thr119Met Mutant | Descriptor: | DI(HYDROXYETHYL)ETHER, Transthyretin | Authors: | Saelices, L, Chung, K, Sawaya, M.R, Cascio, D, Eisenberg, D. | Deposit date: | 2018-07-25 | Release date: | 2019-07-31 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural Variants of Transthyretin To Be Published
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4LF2
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![BU of 4lf2 by Molmil](/molmil-images/mine/4lf2) | Hexameric Form II RuBisCO from Rhodopseudomonas palustris, activated and complexed with sulfate and magnesium | Descriptor: | CARBONATE ION, MAGNESIUM ION, Ribulose bisphosphate carboxylase, ... | Authors: | Chan, S, Satagopan, S, Sawaya, M.R, Eisenberg, D, Tabita, F.R, Perry, L.J. | Deposit date: | 2013-06-26 | Release date: | 2014-06-25 | Last modified: | 2016-07-20 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | Structure-function studies with the unique hexameric form II ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) from Rhodopseudomonas palustris. J.Biol.Chem., 289, 2014
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6E78
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![BU of 6e78 by Molmil](/molmil-images/mine/6e78) | Structure of Human Transthyretin Asp38Ala Mutant in Complex with Diflunisal | Descriptor: | 5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC ACID, Transthyretin | Authors: | Chung, K, Saelices, L, Sawaya, M.R, Cascio, D, Eisenberg, D. | Deposit date: | 2018-07-25 | Release date: | 2019-07-31 | Last modified: | 2019-12-18 | Method: | X-RAY DIFFRACTION (1.499 Å) | Cite: | Structural Variants of Transthyretin To Be Published
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7M62
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![BU of 7m62 by Molmil](/molmil-images/mine/7m62) | Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils seeded by patient extracted fibrils, polymorph 2 | Descriptor: | Islet amyloid polypeptide | Authors: | Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2021-03-25 | Release date: | 2021-09-22 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores Nat.Struct.Mol.Biol., 28, 2021
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7M65
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![BU of 7m65 by Molmil](/molmil-images/mine/7m65) | Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils seeded by patient extracted fibrils, polymorph 4 | Descriptor: | Islet amyloid polypeptide | Authors: | Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2021-03-25 | Release date: | 2021-09-22 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores Nat.Struct.Mol.Biol., 28, 2021
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7M61
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![BU of 7m61 by Molmil](/molmil-images/mine/7m61) | Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils seeded by patient extracted fibrils, polymorph 1 | Descriptor: | Islet amyloid polypeptide | Authors: | Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2021-03-25 | Release date: | 2021-09-22 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores Nat.Struct.Mol.Biol., 28, 2021
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7M64
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![BU of 7m64 by Molmil](/molmil-images/mine/7m64) | Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils seeded by patient extracted fibrils, polymorph 3 | Descriptor: | Islet amyloid polypeptide | Authors: | Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2021-03-25 | Release date: | 2021-09-22 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores Nat.Struct.Mol.Biol., 28, 2021
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2Y3L
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![BU of 2y3l by Molmil](/molmil-images/mine/2y3l) | Structure of segment MVGGVVIA from the amyloid-beta peptide (Ab, residues 35-42), alternate polymorph 2 | Descriptor: | AMYLOID BETA A4 PROTEIN | Authors: | Colletier, J.P, Laganowsky, A, Sawaya, M.R, Eisenberg, D. | Deposit date: | 2010-12-21 | Release date: | 2011-11-02 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Molecular Basis for Amyloid-{Beta} Polymorphism. Proc.Natl.Acad.Sci.USA, 108, 2011
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7K3X
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![BU of 7k3x by Molmil](/molmil-images/mine/7k3x) | |
5E5V
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![BU of 5e5v by Molmil](/molmil-images/mine/5e5v) | Structure of amyloid forming peptide NFGAILS (residues 22-28) from Islet Amyloid Polypeptide | Descriptor: | NFGAILS (22-28) from islet amyloid polypeptide, synthesized | Authors: | Soriaga, A.B, Macdonald, R, Sawaya, M.R, Sangwan, S, Eisenberg, D. | Deposit date: | 2015-10-09 | Release date: | 2015-12-16 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.24 Å) | Cite: | Crystal Structures of IAPP Amyloidogenic Segments Reveal a Novel Packing Motif of Out-of-Register Beta Sheets. J.Phys.Chem.B, 120, 2016
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5ACL
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![BU of 5acl by Molmil](/molmil-images/mine/5acl) | Mcg immunoglobulin variable domain with sulfasalazine | Descriptor: | 2-HYDROXY-(5-([4-(2-PYRIDINYLAMINO)SULFONYL]PHENYL)AZO)BENZOIC ACID, MCG, SULFATE ION | Authors: | Brumshtein, B, Esswein, S.R, Salwinski, L, Phillips, M.L, Ly, A.T, Cascio, D, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2015-08-17 | Release date: | 2015-12-02 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.49 Å) | Cite: | Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain. Elife, 4, 2015
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2Y2A
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![BU of 2y2a by Molmil](/molmil-images/mine/2y2a) | Structure of segment KLVFFA from the amyloid-beta peptide (Ab, residues 16-21), alternate polymorph I | Descriptor: | ACETATE ION, AMYLOID BETA A4 PROTEIN | Authors: | Colletier, J, Laganowsky, A, Sawaya, M.R, Eisenberg, D. | Deposit date: | 2010-12-14 | Release date: | 2011-10-26 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Molecular Basis for Amyloid-{Beta} Polymorphism. Proc.Natl.Acad.Sci.USA, 108, 2011
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6DIX
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![BU of 6dix by Molmil](/molmil-images/mine/6dix) | NFVFGT segment from Human Immunoglobulin Light-Chain Variable Domain, Residues 98-103, assembled as an amyloid fibril | Descriptor: | NFVFGT Immunoglobulin Light-Chain Variable Domain | Authors: | Brumshtein, B, Esswein, S.R, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2018-05-23 | Release date: | 2018-10-31 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | Identification of two principal amyloid-driving segments in variable domains of Ig light chains in systemic light-chain amyloidosis. J. Biol. Chem., 293, 2018
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