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PDB: 34 件
7P85
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BU of 7p85 by Molmil
Engineered phosphotriesterase BdPTE 10-2-C3(C59V/C227V) in complex with ethyl-4-methylbenzylphosphonate
分子名称: FORMIC ACID, GLYCEROL, Parathion hydrolase, ...
著者Eichinger, A, Skerra, A.
登録日2021-07-21
公開日2022-08-03
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.47 Å)
主引用文献Structural and Functional Analysis of a Highly Active Designed Phosphotriesterase for the Detoxification of Organophosphate Nerve Agents Reveals an Unpredicted Conformation of the Active Site Loop.
Biochemistry, 62, 2023
1CVR
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BU of 1cvr by Molmil
Crystal structure of the Arg specific cysteine proteinase gingipain R (RGPB)
分子名称: CALCIUM ION, D-phenylalanyl-N-[(3S)-6-carbamimidamido-1-chloro-2-oxohexan-3-yl]-L-phenylalaninamide, GINGIPAIN R, ...
著者Eichinger, A, Beisel, H.-G.
登録日1999-08-24
公開日2000-03-01
最終更新日2013-10-16
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of gingipain R: an Arg-specific bacterial cysteine proteinase with a caspase-like fold.
EMBO J., 18, 1999
4HH8
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BU of 4hh8 by Molmil
Crystal structure of bovine butyrophilin
分子名称: Butyrophilin subfamily 1 member A1
著者Eichinger, A, Skerra, A.
登録日2012-10-09
公開日2013-11-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The extracellular region of bovine butyrophilin exhibits high structural similarity to human myelin oligodendrocyte glycoprotein
To be Published
3DSZ
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BU of 3dsz by Molmil
Engineered human lipocalin 2 in complex with Y-DTPA
分子名称: N-{(1S,2S)-2-[bis(carboxymethyl)amino]cyclohexyl}-N-{(2R)-2-[bis(carboxymethyl)amino]-3-[4-({[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]carbamothioyl}amino)phenyl]propyl}glycine, YTTRIUM (III) ION, engineered human lipocalin 2
著者Eichinger, A, Skerra, A.
登録日2008-07-14
公開日2009-05-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献High-affinity recognition of lanthanide(III) chelate complexes by a reprogrammed human lipocalin 2
J.Am.Chem.Soc., 131, 2009
3DTQ
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BU of 3dtq by Molmil
Engineered human lipocalin 2 with specificity for Y-DTPA, apo-form
分子名称: Neutrophil gelatinase-associated lipocalin
著者Eichinger, A, Skerra, A.
登録日2008-07-15
公開日2009-05-12
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献High-affinity recognition of lanthanide(III) chelate complexes by a reprogrammed human lipocalin 2.
J.Am.Chem.Soc., 131, 2009
2HZQ
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BU of 2hzq by Molmil
Crystal structure of human apolipoprotein D (ApoD) in complex with progesterone
分子名称: Apolipoprotein D, PROGESTERONE
著者Eichinger, A, Skerra, A.
登録日2006-08-09
公開日2007-08-14
最終更新日2021-10-20
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural insight into the dual ligand specificity and mode of high density lipoprotein association of apolipoprotein d.
J.Biol.Chem., 282, 2007
2HZR
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BU of 2hzr by Molmil
Crystal structure of human apolipoprotein D (ApoD)
分子名称: Apolipoprotein D
著者Eichinger, A, Skerra, A.
登録日2006-08-09
公開日2007-08-14
最終更新日2021-10-20
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural insight into the dual ligand specificity and mode of high density lipoprotein association of apolipoprotein d.
J.Biol.Chem., 282, 2007
3LYA
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BU of 3lya by Molmil
Crystal structure of the periplasmic domain of CadC in the presence of K2ReCl6
分子名称: Transcriptional activator cadC, rhenium (IV) hexachloride
著者Eichinger, A, Skerra, A.
登録日2010-02-26
公開日2011-02-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of the sensory domain of Escherichia coli CadC, a member of the ToxR-like protein family.
Protein Sci., 20, 2011
3LY8
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BU of 3ly8 by Molmil
Crystal structure of mutant D471E of the periplasmic domain of CadC
分子名称: Transcriptional activator cadC
著者Eichinger, A, Skerra, A.
登録日2010-02-26
公開日2011-02-09
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of the sensory domain of Escherichia coli CadC, a member of the ToxR-like protein family.
Protein Sci., 20, 2011
3LY9
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BU of 3ly9 by Molmil
Crystal structure of mutant D471N of the periplasmic domain of CadC
分子名称: Transcriptional activator cadC
著者Eichinger, A, Skerra, A.
登録日2010-02-26
公開日2011-02-09
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure of the sensory domain of Escherichia coli CadC, a member of the ToxR-like protein family.
Protein Sci., 20, 2011
3LY7
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BU of 3ly7 by Molmil
Crystal structure of the periplasmic domain of CadC
分子名称: Transcriptional activator cadC
著者Eichinger, A, Skerra, A.
登録日2010-02-26
公開日2011-02-09
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of the sensory domain of Escherichia coli CadC, a member of the ToxR-like protein family.
Protein Sci., 20, 2011
4IAW
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BU of 4iaw by Molmil
Engineered human lipocalin 2 (C26) in complex with Y-DTPA
分子名称: N-{(1S,2S)-2-[bis(carboxymethyl)amino]cyclohexyl}-N-{(2R)-2-[bis(carboxymethyl)amino]-3-[4-({[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]carbamothioyl}amino)phenyl]propyl}glycine, Neutrophil gelatinase-associated lipocalin, YTTRIUM (III) ION
著者Eichinger, A, Skerra, A.
登録日2012-12-07
公開日2013-06-19
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure-guided engineering of Anticalins with improved binding behavior and biochemical characteristics for application in radio-immuno imaging and/or therapy
J.Struct.Biol., 185, 2014
4IAX
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BU of 4iax by Molmil
Engineered human lipocalin 2 (CL31) in complex with Y-DTPA
分子名称: N-{(1S,2S)-2-[bis(carboxymethyl)amino]cyclohexyl}-N-{(2R)-2-[bis(carboxymethyl)amino]-3-[4-({[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]carbamothioyl}amino)phenyl]propyl}glycine, Neutrophil gelatinase-associated lipocalin, YTTRIUM (III) ION
著者Eichinger, A, Skerra, A.
登録日2012-12-07
公開日2013-06-19
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure-guided engineering of Anticalins with improved binding behavior and biochemical characteristics for application in radio-immuno imaging and/or therapy
J.Struct.Biol., 185, 2014
4MVK
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BU of 4mvk by Molmil
Crystal structure of an engineered lipocalin (Anticalin US7) in complex with the Alzheimer amyloid peptide fragment VFFAED
分子名称: Amyloid peptide fragment VFFAED, Neutrophil gelatinase-associated lipocalin
著者Eichinger, A, Skerra, A.
登録日2013-09-24
公開日2015-08-12
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献High-affinity Anticalins with aggregation-blocking activity directed against the Alzheimer beta-amyloid peptide.
Biochem.J., 473, 2016
4MVL
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BU of 4mvl by Molmil
Crystal structure of an engineered lipocalin (Anticalin H1GA) in complex with the Alzheimer amyloid peptide Abeta1-40
分子名称: Beta-amyloid protein 40, Neutrophil gelatinase-associated lipocalin
著者Eichinger, A, Skerra, A.
登録日2013-09-24
公開日2015-08-12
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献High-affinity Anticalins with aggregation-blocking activity directed against the Alzheimer beta-amyloid peptide.
Biochem.J., 473, 2016
4MVI
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BU of 4mvi by Molmil
Crystal structure of an engineered lipocalin (Anticalin US7) in complex with the Alzheimer amyloid peptide Abeta(1-40)
分子名称: Beta-amyloid protein 40, Neutrophil gelatinase-associated lipocalin
著者Eichinger, A, Skerra, A.
登録日2013-09-24
公開日2015-08-12
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献High-affinity Anticalins with aggregation-blocking activity directed against the Alzheimer beta-amyloid peptide.
Biochem.J., 473, 2016
5MHH
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BU of 5mhh by Molmil
Crystal structure of engineered human lipocalin 2 carrying p-boronophenylalanine at position 36
分子名称: Neutrophil gelatinase-associated lipocalin, SULFATE ION
著者Skerra, A, Eichinger, A.
登録日2016-11-24
公開日2017-10-11
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Rational Design of an Anticalin-Type Sugar-Binding Protein Using a Genetically Encoded Boronate Side Chain.
ACS Synth Biol, 6, 2017
8B50
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BU of 8b50 by Molmil
Crystal structure of a Fab fragment in complex with L-hydroxycoumarylalanine
分子名称: (2~{S})-2-azanyl-3-(7-oxidanyl-2-oxidanylidene-chromen-4-yl)propanoic acid, Fab fragment K12F9-22 - heavy chain, Fab fragment K12F9-22 - light chain, ...
著者Meining, W, Eichinger, A, Skerra, A.
登録日2022-09-21
公開日2023-10-04
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献Preparation and characterization of monoclonal antibodies against a non natural amino acid carrying the 7-hydroxycoumarin side chain
To be published
1VR1
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BU of 1vr1 by Molmil
Specifity for Plasminogen Activator Inhibitor-1
分子名称: Hirudin, thrombin
著者Dekker, R.J, Eichinger, A, Stoop, A.A, Bode, W, Pannekoek, H, Horrevoets, A.J.G.
登録日1998-12-11
公開日1999-12-29
最終更新日2022-12-21
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The variable region-1 from tissue-type plasminogen activator confers specificity for plasminogen activator inhibitor-1 to thrombin by facilitating catalysis: release of a kinetic block by a heterologous protein surface loop
J.Mol.Biol., 293, 1999
5NBW
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BU of 5nbw by Molmil
Crystal structure of the Fab fragment 22F12 in complex with 3-hydroxybenzo[a]pyrene
分子名称: Fab 22F12 (A,B), Fab 22F12 (L,H), benzo[a]pyren-3-ol
著者Skerra, A, Eichinger, A.
登録日2017-03-02
公開日2017-06-28
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Tight Molecular Recognition of Benzo[a]pyrene by a High-Affinity Antibody.
Angew. Chem. Int. Ed. Engl., 56, 2017
6GR0
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BU of 6gr0 by Molmil
Petrobactin-binding engineered lipocalin in complex with gallium-petrobactin
分子名称: 4-[4-[3-[[3,4-bis(oxidanyl)phenyl]carbonylamino]propylamino]butylamino]-2-[2-[4-[3-[[3,4-bis(oxidanyl)phenyl]carbonylamino]propylamino]butylamino]-2-oxidanylidene-ethyl]-2-oxidanyl-4-oxidanylidene-butanoic acid, GALLIUM (III) ION, Neutrophil gelatinase-associated lipocalin
著者Skerra, A, Eichinger, A.
登録日2018-06-08
公開日2018-08-15
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Reprogramming Human Siderocalin To Neutralize Petrobactin, the Essential Iron Scavenger of Anthrax Bacillus.
Angew. Chem. Int. Ed. Engl., 57, 2018
6GQZ
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BU of 6gqz by Molmil
Petrobactin-binding engineered lipocalin without ligand
分子名称: Neutrophil gelatinase-associated lipocalin
著者Skerra, A, Eichinger, A.
登録日2018-06-08
公開日2018-08-15
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Reprogramming Human Siderocalin To Neutralize Petrobactin, the Essential Iron Scavenger of Anthrax Bacillus.
Angew. Chem. Int. Ed. Engl., 57, 2018
5NKN
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BU of 5nkn by Molmil
Crystal structure of an Anticalin-colchicine complex
分子名称: N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide, Neutrophil gelatinase-associated lipocalin
著者Skerra, A, Eichinger, A, Barkovskiy, M.
登録日2017-03-31
公開日2018-04-04
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献An engineered lipocalin that tightly complexes the plant poison colchicine for use as antidote and in bioanalytical applications.
Biol. Chem., 400, 2019
6ZVF
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BU of 6zvf by Molmil
Crystal structure of the recombinant Fab fragment derived from the hybridoma M3/38 in complex with a human Galectin-3 peptide
分子名称: Chimeric Fab M3/38 (L,H), Galectin-3
著者Skerra, A, Eichinger, A.
登録日2020-07-24
公開日2021-04-14
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Effective rational humanization of a PASylated anti-galectin-3 Fab for the sensitive PET imaging of thyroid cancer in vivo.
Sci Rep, 11, 2021
6Z2C
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BU of 6z2c by Molmil
Engineered lipocalin C3A5 in complex with a transition state analog
分子名称: 1,7,8,9,10,10-hexachloro-4-carboxypentyl-4-aza-tricyclo[5.2.1.0(2,6)]dec-8-ene-3,5-dione, Neutrophil gelatinase-associated lipocalin
著者Skerra, A, Eichinger, A.
登録日2020-05-15
公開日2021-05-26
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure of an engineered lipocalin that catalyzes a Diels-Alder reaction
To be published

 

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