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PDB: 480 件
4WYB
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BU of 4wyb by Molmil
Structure of the Bud6 flank domain in complex with actin
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Actin, alpha skeletal muscle, ...
著者Eck, M.J, Park, E, Zheng, W.
登録日2014-11-17
公開日2015-08-19
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.493 Å)
主引用文献Structure of a Bud6/Actin Complex Reveals a Novel WH2-like Actin Monomer Recruitment Motif.
Structure, 23, 2015
1TNF
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BU of 1tnf by Molmil
THE STRUCTURE OF TUMOR NECROSIS FACTOR-ALPHA AT 2.6 ANGSTROMS RESOLUTION. IMPLICATIONS FOR RECEPTOR BINDING
分子名称: TUMOR NECROSIS FACTOR-ALPHA
著者Eck, M.J, Sprang, S.R.
登録日1989-08-25
公開日1990-01-15
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献The structure of tumor necrosis factor-alpha at 2.6 A resolution. Implications for receptor binding.
J.Biol.Chem., 264, 1989
4ZJV
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BU of 4zjv by Molmil
crystal structure of EGFR kinase domain in complex with Mitogen-inducible gene 6 protein
分子名称: ERBB receptor feedback inhibitor 1, Epidermal growth factor receptor
著者Eck, M.J, Park, E, Lee, B.
登録日2015-04-29
公開日2015-08-12
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6.
Nat.Struct.Mol.Biol., 22, 2015
8DGT
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BU of 8dgt by Molmil
Cryo-EM structure of a RAS/RAF complex (state 2)
分子名称: 14-3-3 protein zeta, 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, ...
著者Eck, M.J, Jeon, H, Park, E, Rawson, S.
登録日2022-06-24
公開日2023-07-05
最終更新日2023-08-09
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Cryo-EM structure of a RAS/RAF recruitment complex.
Nat Commun, 14, 2023
8DGS
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BU of 8dgs by Molmil
Cryo-EM structure of a RAS/RAF complex (state 1)
分子名称: 14-3-3 protein zeta, 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, ...
著者Eck, M.J, Jeon, H, Park, E, Rawson, S.
登録日2022-06-24
公開日2023-07-05
最終更新日2023-08-09
実験手法ELECTRON MICROSCOPY (4.3 Å)
主引用文献Cryo-EM structure of a RAS/RAF recruitment complex.
Nat Commun, 14, 2023
5U1M
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BU of 5u1m by Molmil
Structure of the IRS-1 PTB Domain Bound to the Juxtamembrane Region of the Insulin Receptor
分子名称: Insulin receptor, Insulin receptor substrate 1
著者Eck, M.J, Dhe-Paganon, S.
登録日2016-11-28
公開日2017-09-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression.
Nat Commun, 8, 2017
4K11
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BU of 4k11 by Molmil
The structure of 1NA in complex with Src T338G
分子名称: 1-tert-butyl-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Proto-oncogene tyrosine-protein kinase Src
著者Eck, M.J, Yun, C.H.
登録日2013-04-04
公開日2014-04-09
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The structure of 1NA in complex with Src T338G
To be Published
1QZY
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BU of 1qzy by Molmil
Human Methionine Aminopeptidase in complex with bengamide inhibitor LAF153 and cobalt
分子名称: (E)-(2R,3R,4S,5R)-3,4,5-TRIHYDROXY-2-METHOXY-8,8-DIMETHYL-NON-6-ENOIC ACID ((3S,6R)-6-HYDROXY-2-OXO-AZEPAN-3-YL)-AMIDE, COBALT (II) ION, Methionine aminopeptidase 2, ...
著者Eck, M.J, Song, H.K, Morollo, A.
登録日2003-09-18
公開日2003-11-25
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Proteomics-based target identification: bengamides as a new class of methionine aminopeptidase inhibitors.
J.Biol.Chem., 278, 2003
1LCJ
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BU of 1lcj by Molmil
SH2 (SRC HOMOLOGY-2) DOMAIN OF HUMAN P56-LCK TYROSINE KINASE COMPLEXED WITH THE 11 RESIDUE PHOSPHOTYROSYL PEPTIDE EPQPYEEIPIYL
分子名称: P56==LCK== TYROSINE KINASE, PHOSPHOPEPTIDE EPQ(PHOSPHO)YEEIPIYL
著者Eck, M, Harrison, S.
登録日1994-12-12
公開日1995-10-15
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck.
Nature, 362, 1993
1LCK
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BU of 1lck by Molmil
SH3-SH2 DOMAIN FRAGMENT OF HUMAN P56-LCK TYROSINE KINASE COMPLEXED WITH THE 10 RESIDUE SYNTHETIC PHOSPHOTYROSYL PEPTIDE TEGQPYQPQPA
分子名称: P56==LCK== TYROSINE KINASE, TAIL PHOSPHOPEPTIDE TEGQ(PHOSPHO)YQPQPA
著者Eck, M, Harrison, S.
登録日1994-12-12
公開日1995-10-15
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of the regulatory domains of the Src-family tyrosine kinase Lck.
Nature, 368, 1994
3O4X
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BU of 3o4x by Molmil
Crystal structure of complex between amino and carboxy terminal fragments of mDia1
分子名称: Protein diaphanous homolog 1
著者Eck, M.J, Nezami, A, Toms, A.V.
登録日2010-07-27
公開日2010-10-13
最終更新日2012-04-11
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Crystal structure of a complex between amino and carboxy terminal fragments of mDia1: insights into autoinhibition of diaphanous-related formins.
Plos One, 5, 2010
6CF1
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BU of 6cf1 by Molmil
Proteus vulgaris HigA antitoxin structure
分子名称: Antitoxin HigA, POTASSIUM ION
著者Schureck, M.A, Hoffer, E.D, Ei Cho, S, Dunham, C.M.
登録日2018-02-13
公開日2019-02-27
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural basis of transcriptional regulation by the HigA antitoxin.
Mol.Microbiol., 111, 2019
6W1D
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BU of 6w1d by Molmil
Structure of human mitochondrial complex Nfs1-ISCU2 (WT)-ISD11 with E.coli ACP1 at 1.8 A resolution (NIAU)2
分子名称: 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, ...
著者Boniecki, M.T, Cygler, M.
登録日2020-03-04
公開日2020-03-18
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.795 Å)
主引用文献The essential function of ISCU2 and its conserved N-terminus in Fe/S cluster biogenesis
To Be Published
4W4G
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BU of 4w4g by Molmil
Postcleavage state of 70S bound to HigB toxin and AAA (lysine) codon
分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ...
著者Schureck, M.A, Maehigashi, T, Dunkle, J.A, Dunham, C.M.
登録日2014-08-14
公開日2015-10-21
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Defining the mRNA recognition signature of a bacterial toxin protein.
Proc.Natl.Acad.Sci.USA, 112, 2015
6WIH
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BU of 6wih by Molmil
N-terminal mutation of ISCU2 (L35H36) traps Nfs1 Cys loop in the active site of ISCU2 without metal present. Structure of human mitochondrial complex Nfs1-ISCU2(L35H36)-ISD11 with E.coli ACP1 at 1.9 A resolution (NIAU)2.
分子名称: 1,2-ETHANEDIOL, 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, Acyl carrier protein, ...
著者Boniecki, M.T, Cygler, M.
登録日2020-04-09
公開日2020-05-13
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The essential function of ISCU2 and its conserved N-terminus in Fe/S cluster biogenesis
To Be Published
6WI2
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BU of 6wi2 by Molmil
Structure of human mitochondrial complex Nfs1-ISCU2-ISD11 with E.coli ACP1 at 1.95 A resolution (NIAU)2. N-terminal mutation of ISCU2 (L35) traps Nfs1 Cys loop in the active site of ISCU2 without metal present.
分子名称: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, ...
著者Boniecki, M.T, Cygler, M.
登録日2020-04-08
公開日2020-04-22
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献The essential function of ISCU2 and its conserved N-terminus in Fe/S cluster biogenesis
To Be Published
5WLW
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BU of 5wlw by Molmil
Crystal Structure of the Human Mitochondrial Cysteine Desulfurase with active Cysteine Loop within ISCU1 active site, coordinating Zn ion. Complexed with human ISD11 and E. coli ACP1 at 3.3A.
分子名称: Acyl carrier protein, Cysteine desulfurase, mitochondrial, ...
著者Boniecki, M.T, Cygler, M.
登録日2017-07-27
公開日2017-11-15
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.317 Å)
主引用文献Structure and functional dynamics of the mitochondrial Fe/S cluster synthesis complex.
Nat Commun, 8, 2017
2VFM
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BU of 2vfm by Molmil
Low Temperature Structure of P22 Tailspike Protein Fragment (109-666)
分子名称: BIFUNCTIONAL TAIL PROTEIN, CALCIUM ION, GLYCEROL, ...
著者Becker, M, Mueller, J.J, Heinemann, U, Seckler, R.
登録日2007-11-05
公開日2008-12-16
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Side-Chain Stacking and Beta-Helix Stability in P22 Tailspike Protein
To be Published
2VFN
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BU of 2vfn by Molmil
Low Temperature Structure of P22 Tailspike Protein Fragment (109-666), Mutant V125A
分子名称: BIFUNCTIONAL TAIL PROTEIN, CALCIUM ION, GLYCEROL, ...
著者Becker, M, Mueller, J.J, Heinemann, U, Seckler, R.
登録日2007-11-05
公開日2008-12-16
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Side-Chain Stacking and Beta-Helix Stability in P22 Tailspike Protein
To be Published
5WKP
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BU of 5wkp by Molmil
Crystal Structure of the Human mitochondrial Cysteine Desulfurase in complex with ISD11 and Iron-Sulfur Cluster Scaffold Protein ISCU1, and E. coli ACP1 protein at 3.15A
分子名称: Acyl carrier protein, Cysteine desulfurase, mitochondrial, ...
著者Boniecki, M.T, Cygler, M.
登録日2017-07-25
公開日2017-11-15
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献Structure and functional dynamics of the mitochondrial Fe/S cluster synthesis complex.
Nat Commun, 8, 2017
5WGB
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BU of 5wgb by Molmil
Crystal Structure of the Human mitochondrial Cysteine Desulfurase in complex with ISD11 and E. coli ACP1 protein at 2.75A
分子名称: Acyl carrier protein, Cysteine desulfurase, mitochondrial, ...
著者Boniecki, M.T, Cygler, M.
登録日2017-07-13
公開日2017-07-26
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Structure and functional dynamics of the mitochondrial Fe/S cluster synthesis complex.
Nat Commun, 8, 2017
8OYU
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BU of 8oyu by Molmil
Stabilised BA.1 SARS-CoV-2 spike with H6 nanobodies in '2 up 1 down' RBD conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, H6 nanobody, ...
著者Weckener, M, Naismith, J.H, Owens, R.J.
登録日2023-05-05
公開日2024-05-15
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Structural and functional characterization of nanobodies that neutralize Omicron variants of SARS-CoV-2.
Open Biology, 14, 2024
5M73
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BU of 5m73 by Molmil
Structure of the human SRP S domain with SRP72 RNA-binding domain
分子名称: GLYCEROL, Human gene for small cytoplasmic 7SL RNA (7L30.1), MAGNESIUM ION, ...
著者Becker, M.M.M, Wild, K, Sinning, I.
登録日2016-10-26
公開日2016-12-07
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Structures of human SRP72 complexes provide insights into SRP RNA remodeling and ribosome interaction.
Nucleic Acids Res., 45, 2017
8OYT
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BU of 8oyt by Molmil
Stabilised BA.1 SARS-CoV-2 spike with H6 nanobodies in '3 up' RBD conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, H6 nanobody, ...
著者Weckener, M, Naismith, J.H, Owens, R.J.
登録日2023-05-05
公開日2024-07-03
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Structural and functional characterization of nanobodies that neutralize Omicron variants of SARS-CoV-2.
Open Biology, 14, 2024
2VFO
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BU of 2vfo by Molmil
Low Temperature Structure of P22 Tailspike Protein Fragment (109-666), Mutant V125L
分子名称: CALCIUM ION, GLYCEROL, P22 TAILSPIKE PROTEIN, ...
著者Becker, M, Mueller, J.J, Heinemann, U, Seckler, R.
登録日2007-11-05
公開日2008-12-16
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Side-Chain Stacking and Beta-Helix Stability in P22 Tailspike Protein
To be Published

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