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PDB: 27 件
8C7H
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BU of 8c7h by Molmil
Cryo-EM Map of the latTGF-beta 28G11 Fab complex
分子名称: 28G11 Fab heavy chain, 28G11 Fab light chain, Transforming growth factor beta activator LRRC32, ...
著者Ebenhoch, R, Nar, H.
登録日2023-01-16
公開日2023-03-01
最終更新日2023-03-29
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Anti-GARP Antibodies Inhibit Release of TGF-beta by Regulatory T Cells via Different Modes of Action, but Do Not Influence Their Function In Vitro.
Immunohorizons, 7, 2023
6SVL
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BU of 6svl by Molmil
human Myeloid-derived growth factor (MYDGF) in complex with neutralizing Fab
分子名称: Fab_heavy_chain, Fab_light_chain, GLYCEROL, ...
著者Ebenhoch, R, Nar, H.
登録日2019-09-18
公開日2019-11-27
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Crystal structure and receptor-interacting residues of MYDGF - a protein mediating ischemic tissue repair.
Nat Commun, 10, 2019
6SVK
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BU of 6svk by Molmil
human Myeloid-derived growth factor (MYDGF)
分子名称: MALONATE ION, Myeloid-derived growth factor
著者Ebenhoch, R, Nar, H.
登録日2019-09-18
公開日2019-11-27
最終更新日2019-12-04
実験手法X-RAY DIFFRACTION (1.604 Å)
主引用文献Crystal structure and receptor-interacting residues of MYDGF - a protein mediating ischemic tissue repair.
Nat Commun, 10, 2019
6Z86
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BU of 6z86 by Molmil
human GTP cyclohydrolase I in complex with 7-deaza-GTP
分子名称: 7-deaza-GTP, GTP cyclohydrolase 1, ZINC ION
著者Ebenhoch, R, Nar, H.
登録日2020-06-02
公開日2020-12-09
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.206 Å)
主引用文献A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I.
Proc.Natl.Acad.Sci.USA, 117, 2020
6Z88
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BU of 6z88 by Molmil
human GTP cyclohydrolase I in complex with allosteric inhibitor
分子名称: 5-azanyl-[1,3]thiazolo[5,4-d]pyrimidine-2,7-dione, GTP cyclohydrolase 1, ZINC ION
著者Ebenhoch, R, Nar, H.
登録日2020-06-02
公開日2020-12-09
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.687 Å)
主引用文献A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I.
Proc.Natl.Acad.Sci.USA, 117, 2020
6Z89
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human GTP cyclohydrolase I in complex with allosteric inhibitor
分子名称: 5-azanyl-[1,3]thiazolo[5,4-d]pyrimidine-2,7-dione, GTP cyclohydrolase 1, ZINC ION
著者Ebenhoch, R, Nar, H.
登録日2020-06-02
公開日2020-12-09
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.366 Å)
主引用文献A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I.
Proc.Natl.Acad.Sci.USA, 117, 2020
6Z80
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BU of 6z80 by Molmil
stimulatory human GTP cyclohydrolase I - GFRP complex
分子名称: 8-OXO-GUANOSINE-5'-TRIPHOSPHATE, GTP cyclohydrolase 1, GTP cyclohydrolase 1 feedback regulatory protein, ...
著者Ebenhoch, R, Nar, H, Vonck, J.
登録日2020-06-02
公開日2020-12-09
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I.
Proc.Natl.Acad.Sci.USA, 117, 2020
6Z87
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BU of 6z87 by Molmil
human GTP cyclohydrolase I
分子名称: GTP cyclohydrolase 1, ZINC ION
著者Ebenhoch, R, Nar, H.
登録日2020-06-02
公開日2020-12-09
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.564 Å)
主引用文献A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I.
Proc.Natl.Acad.Sci.USA, 117, 2020
6Z85
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inhibitory human GTP cyclohydrolase I - GFRP complex
分子名称: 7,8-DIHYDROBIOPTERIN, GTP cyclohydrolase 1, GTP cyclohydrolase 1 feedback regulatory protein, ...
著者Ebenhoch, R, Nar, H, Vonck, J.
登録日2020-06-02
公開日2020-12-09
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I.
Proc.Natl.Acad.Sci.USA, 117, 2020
8OME
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BU of 8ome by Molmil
Crystal structure of hKHK-A in complex with compound-4
分子名称: Ketohexokinase, compound
著者Ebenhoch, R, Pautsch, A.
登録日2023-03-31
公開日2023-09-27
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structures of human and mouse ketohexokinase provide a structural basis for species- and isoform-selective inhibitor design.
Acta Crystallogr D Struct Biol, 79, 2023
8OMF
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BU of 8omf by Molmil
Crystal structure of hKHK-C in complex with compound-4
分子名称: Ketohexokinase, SULFATE ION, compound
著者Ebenhoch, R, Pautsch, A.
登録日2023-03-31
公開日2023-09-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Crystal structures of human and mouse ketohexokinase provide a structural basis for species- and isoform-selective inhibitor design.
Acta Crystallogr D Struct Biol, 79, 2023
8OMD
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Crystal structure of mKHK in complex with compound-4
分子名称: Ketohexokinase, compound
著者Ebenhoch, R, Pautsch, A.
登録日2023-03-31
公開日2023-09-27
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structures of human and mouse ketohexokinase provide a structural basis for species- and isoform-selective inhibitor design.
Acta Crystallogr D Struct Biol, 79, 2023
8OMK
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BU of 8omk by Molmil
hKHK-C in complex with ADP & fructose 1-phosphate
分子名称: 1-O-phosphono-beta-D-fructofuranose, ADENOSINE-5'-DIPHOSPHATE, Ketohexokinase, ...
著者Ebenhoch, R, Pautsch, A.
登録日2023-03-31
公開日2024-01-10
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献Discovery of BI-9787, a Potent Zwitterionic KHK-Inhibitor with Oral Bioavailability
To Be Published
7AL9
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BU of 7al9 by Molmil
human GTP cyclohydrolase I feedback regulatory protein (GFRP) in complex with phenylalanine
分子名称: GTP cyclohydrolase 1 feedback regulatory protein, PHENYLALANINE, POTASSIUM ION
著者Ebenhoch, R, Nar, H.
登録日2020-10-06
公開日2021-10-13
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.745 Å)
主引用文献A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I.
Proc.Natl.Acad.Sci.USA, 117, 2020
7ALA
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BU of 7ala by Molmil
human GCH-GFRP inhibitory complex
分子名称: 2-azanyl-8-[(4-fluorophenyl)methylsulfanyl]-1,7-dihydropurin-6-one, GTP cyclohydrolase 1, GTP cyclohydrolase 1 feedback regulatory protein, ...
著者Ebenhoch, R, Nar, H.
登録日2020-10-06
公開日2021-10-13
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.846 Å)
主引用文献A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I.
Proc.Natl.Acad.Sci.USA, 117, 2020
7ALC
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BU of 7alc by Molmil
human GCH-GFRP stimulatory complex
分子名称: GTP cyclohydrolase 1, GTP cyclohydrolase 1 feedback regulatory protein, PHENYLALANINE, ...
著者Ebenhoch, R, Nar, H.
登録日2020-10-06
公開日2021-10-13
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.726 Å)
主引用文献A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I.
Proc.Natl.Acad.Sci.USA, 117, 2020
7ALB
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BU of 7alb by Molmil
human GCH-GFRP stimulatory complex 7-deaza-GTP bound
分子名称: 7-deaza-GTP, GTP cyclohydrolase 1, GTP cyclohydrolase 1 feedback regulatory protein, ...
著者Ebenhoch, R, Nar, H.
登録日2020-10-06
公開日2021-10-13
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.979 Å)
主引用文献A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I.
Proc.Natl.Acad.Sci.USA, 117, 2020
7ACC
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BU of 7acc by Molmil
human GTP cyclohydrolase I feedback regulatory protein (GFRP)
分子名称: GTP cyclohydrolase 1 feedback regulatory protein, POTASSIUM ION
著者Ebenhoch, R, Nar, H.
登録日2020-09-10
公開日2020-12-09
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I.
Proc.Natl.Acad.Sci.USA, 117, 2020
7AIR
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BU of 7air by Molmil
Structure of Human Potassium Chloride Transporter KCC1 in NaCl (Subclass 2)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ...
著者Ebenhoch, R, Chi, G, Man, H, Wang, D, McKinley, G, Mukhopadhyay, S.M.M, MacLean, E.M, Chalk, R, Moreau, C, Snee, M, Bohstedt, T, Singh, N.K, Abrusci, P, Liko, I, Tehan, B.G, Almeida, F.G, Arrowsmith, C.H, Tang, H, Robinson, C.V, Bountra, C, Edwards, A.M, Marsden, B.D, Burgess-Brown, N.A, Duerr, K.L, Structural Genomics Consortium (SGC)
登録日2020-09-28
公開日2021-06-02
最終更新日2021-07-28
実験手法ELECTRON MICROSCOPY (3.66 Å)
主引用文献Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters.
Embo J., 40, 2021
7AIQ
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BU of 7aiq by Molmil
Structure of Human Potassium Chloride Transporter KCC1 in NaCl (Subclass 1)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, Solute carrier family 12 member 4, ...
著者Ebenhoch, R, Chi, G, Man, H, Wang, D, McKinley, G, Mukhopadhyay, S.M.M, MacLean, E.M, Chalk, R, Moreau, C, Snee, M, Bohstedt, T, Singh, N.K, Abrusci, P, Liko, I, Tehan, B.G, Almeida, F.G, Arrowsmith, C.H, Tang, H, Robinson, C.V, Bountra, C, Edwards, A.M, Marsden, B.D, Burgess-Brown, N.A, Duerr, K.L, Structural Genomics Consortium (SGC)
登録日2020-09-28
公開日2021-06-02
最終更新日2021-07-28
実験手法ELECTRON MICROSCOPY (3.72 Å)
主引用文献Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters.
Embo J., 40, 2021
7AIP
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BU of 7aip by Molmil
Structure of Human Potassium Chloride Transporter KCC1 in NaCl (Reference Map)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
著者Ebenhoch, R, Chi, G, Man, H, Wang, D, McKinley, G, Mukhopadhyay, S.M.M, MacLean, E.M, Chalk, R, Moreau, C, Snee, M, Bohstedt, T, Liko, I, Tehan, B.G, Almeida, F.G, Elkins, J, Singh, N.K, Abrusci, P, Arrowsmith, C.H, Tang, H, Robinson, C.V, Bountra, C, Edwards, A.M, Marsden, B.D, Burgess-Brown, N.A, Duerr, K.L, Structural Genomics Consortium (SGC)
登録日2020-09-28
公開日2021-06-02
最終更新日2021-07-28
実験手法ELECTRON MICROSCOPY (3.12 Å)
主引用文献Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters.
Embo J., 40, 2021
7ALQ
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BU of 7alq by Molmil
human GCH-GFRP inhibitory complex 7-deaza-GTP bound
分子名称: 7,8-DIHYDROBIOPTERIN, 7-deaza-GTP, GTP cyclohydrolase 1, ...
著者Ebenhoch, R, Nar, H.
登録日2020-10-07
公開日2021-10-20
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.205 Å)
主引用文献Biophysical and structural investigation of the regulation of human GTP cyclohydrolase I by its regulatory protein GFRP.
J.Struct.Biol., 213, 2021
6Y5R
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BU of 6y5r by Molmil
Structure of Human Potassium Chloride Transporter KCC3 S45D/T940D/T997D in NaCl
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Solute carrier family 12 member 6, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Chi, G, Man, H, Ebenhoch, R, Reggiano, G, Pike, A.C.W, Wang, D, McKinley, G, Mukhopadhyay, S.M.M, MacLean, B, Chalk, R, Moreau, C, Snee, M, Bohstedt, T, Singh, N.K, Abrusci, P, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Marsden, B.D, Burgess-Brown, N.A, DiMaio, F, Duerr, K.L, Structural Genomics Consortium (SGC)
登録日2020-02-25
公開日2020-03-11
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3.76 Å)
主引用文献Structure of Human Potassium Chloride Transporter KCC3 in NaCl
To be published
6Y5V
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Structure of Human Potassium Chloride Transporter KCC3b (S45D/T940D/T997D) in KCl
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Solute carrier family 12 member 6, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Chi, G, Man, H, Ebenhoch, R, Reggiano, G, Pike, A.C.W, Wang, D, McKinley, G, Mukhopadhyay, S.M.M, MacLean, E.M, Chalk, R, Moreau, C, Snee, M, Bohstedt, T, Singh, N.K, Abrusci, P, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Marsden, B.D, Burgess-Brown, N.A, DiMaio, F, Duerr, K.L.
登録日2020-02-25
公開日2020-07-15
最終更新日2021-07-28
実験手法ELECTRON MICROSCOPY (4.08 Å)
主引用文献Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters.
Embo J., 40, 2021
8OMJ
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BU of 8omj by Molmil
hKHK-C in complex with compound 28
分子名称: Ketohexokinase, SULFATE ION, [3-[[6-[(3~{a}~{R},6~{a}~{S})-2,3,3~{a},4,6,6~{a}-hexahydro-1~{H}-pyrrolo[3,4-c]pyrrol-5-yl]-3-cyano-4-(trifluoromethyl)pyridin-2-yl]amino]-4-methylsulfanyl-phenyl]methoxy-methyl-phosphinic acid
著者Pautsch, A, Ebenhoch, R.
登録日2023-03-31
公開日2024-07-10
最終更新日2024-07-31
実験手法X-RAY DIFFRACTION (1.978 Å)
主引用文献Discovery of BI-9787, a Potent Zwitterionic KHK-Inhibitor with Oral Bioavailability
To Be Published

 

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