8C0F
| Tubulin-PTC596 complex | Descriptor: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5-fluoranyl-2-(6-fluoranyl-2-methyl-benzimidazol-1-yl)-~{N}4-[4-(trifluoromethyl)phenyl]pyrimidine-4,6-diamine, ... | Authors: | Prota, A.E, Muehlethaler, T, Weetall, M, Steinmetz, M.O. | Deposit date: | 2022-12-16 | Release date: | 2022-12-28 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.1005 Å) | Cite: | Preclinical and Early Clinical Development of PTC596, a Novel Small-Molecule Tubulin-Binding Agent Mol Cancer Ther, 20, 2021
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4XHC
| rhamnosidase from Klebsiella oxytoca with rhamnose bound | Descriptor: | Alpha-L-rhamnosidase, SULFATE ION, alpha-L-rhamnopyranose | Authors: | O'Neill, E.O, Stevenson, C.E.M, Patterson, M.J, Rejzek, M, Chauvin, A, Lawson, D.M, Field, R.A. | Deposit date: | 2015-01-05 | Release date: | 2015-04-15 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of a novel two domain GH78 family alpha-rhamnosidase from Klebsiella oxytoca with rhamnose bound. Proteins, 83, 2015
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7N6B
| Structure of MmpL3 reconstituted into lipid nanodisc in the TMM bound state | Descriptor: | 6-O-[(2S)-2-{(1S)-18-[(1R,2R)-2-hexylcyclopropyl]-1-hydroxyoctadecyl}tricosanoyl]-alpha-D-glucopyranosyl alpha-D-glucopyranoside, MmpL3 transporter | Authors: | Su, C.C, Yu, E. | Deposit date: | 2021-06-08 | Release date: | 2021-09-01 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.66 Å) | Cite: | Structures of the mycobacterial membrane protein MmpL3 reveal its mechanism of lipid transport. Plos Biol., 19, 2021
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7B3J
| Dynamic complex between all-D-enantiomeric peptide D3 with wild-type amyloid precursor protein 672-726 fragment (amyloid beta 1-55) | Descriptor: | D3 all D-enantimeric peptide, Isoform L-APP677 of Amyloid-beta precursor protein | Authors: | Bocharov, E.V, Volynsky, P.E, Okhrimenko, I.S, Urban, A.S. | Deposit date: | 2020-12-01 | Release date: | 2021-01-13 | Last modified: | 2021-12-08 | Method: | SOLUTION NMR | Cite: | All - d - Enantiomeric Peptide D3 Designed for Alzheimer's Disease Treatment Dynamically Interacts with Membrane-Bound Amyloid-beta Precursors. J.Med.Chem., 64, 2021
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8C8F
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1IK3
| LIPOXYGENASE-3 (SOYBEAN) COMPLEX WITH 13(S)-HYDROPEROXY-9(Z),11(E)-OCTADECADIENOIC ACID | Descriptor: | (TRANS-12,13-EPOXY)-11-HYDROXY-9(Z)-OCTADECENOIC ACID, (TRANS-12,13-EPOXY)-9-HYDROXY-10(E)-OCTADECENOIC ACID, 13(R)-HYDROPEROXY-9(Z),11(E)-OCTADECADIENOIC ACID, ... | Authors: | Skrzypczak-Jankun, E, Funk Jr, M.O. | Deposit date: | 2001-05-01 | Release date: | 2001-11-14 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Three-dimensional structure of a purple lipoxygenase. J.Am.Chem.Soc., 123, 2001
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5IZQ
| Crystal structure of human folate receptor alpha in complex with novel antifolate AGF183 | Descriptor: | Folate receptor alpha, N-(4-{[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)ethyl]amino}benzene-1-carbonyl)-L-glutamic acid | Authors: | Ke, J, Gu, X, Brunzelle, J.S, Xu, H.E, Melcher, K. | Deposit date: | 2016-03-25 | Release date: | 2016-08-10 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor alpha and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis. J.Med.Chem., 59, 2016
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6LKF
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6M3N
| Solution structure of anti-CRISPR AcrIF7 | Descriptor: | anti-CRIPSR AcrIF7 | Authors: | Kim, I, An, S.Y, Koo, J, Bae, E, Suh, J.Y. | Deposit date: | 2020-03-04 | Release date: | 2020-08-26 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural and mechanistic insights into the CRISPR inhibition of AcrIF7. Nucleic Acids Res., 48, 2020
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6BAK
| The structure of the Stigmatella aurantiaca phytochrome chromophore binding domain T289H mutant | Descriptor: | 3-[5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-2-[[5-[(Z)-(3-ethenyl-4-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-3-(3-hydroxy-3-oxopropyl)-4-methyl-1H-pyrrol-2-yl]methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid, Photoreceptor-histidine kinase BphP | Authors: | Schmidt, M, Stojkovic, E. | Deposit date: | 2017-10-13 | Release date: | 2018-09-19 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Structural basis for light control of cell development revealed by crystal structures of a myxobacterial phytochrome. IUCrJ, 5, 2018
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6MH7
| Crystal structure of the first bromodomain of human BRD4 in complex with SKT-68, a 1,4,5-trisubstituted imidazole analogue | Descriptor: | 1,2-ETHANEDIOL, Bromodomain-containing protein 4, DIMETHYL SULFOXIDE, ... | Authors: | Zhu, J.-Y, Schonbrunn, E. | Deposit date: | 2018-09-17 | Release date: | 2019-08-07 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.74 Å) | Cite: | Molecular Basis for the N-Terminal Bromodomain-and-Extra-Terminal-Family Selectivity of a Dual Kinase-Bromodomain Inhibitor. J.Med.Chem., 61, 2018
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7AML
| RET/GDNF/GFRa1 extracellular complex Cryo-EM structure | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GDNF family receptor alpha, ... | Authors: | Adams, S.E, Earl, C.P, Purkiss, A.G, McDonald, N.Q. | Deposit date: | 2020-10-09 | Release date: | 2021-01-13 | Last modified: | 2021-07-14 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | A two-site flexible clamp mechanism for RET-GDNF-GFR alpha 1 assembly reveals both conformational adaptation and strict geometric spacing. Structure, 29, 2021
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4XRA
| Salmonella typhimurium AhpC T43S mutant | Descriptor: | Alkyl hydroperoxide reductase subunit C, CHLORIDE ION, POTASSIUM ION, ... | Authors: | Perkins, A, Brereton, A.E, Nelson, K, Parsonage, D, Poole, L, Karplus, P.A. | Deposit date: | 2015-01-20 | Release date: | 2016-01-20 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Experimentally Dissecting the Origins of Peroxiredoxin Catalysis. Antioxid.Redox Signal., 28, 2018
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6MHE
| Galphai3 co-crystallized with KB752 | Descriptor: | GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(k) subunit alpha, ... | Authors: | Rees, S.D, Kalogriopoulos, N.A, Ngo, T, Kopcho, N, Ilatovskiy, A, Sun, N, Komives, E, Chang, G, Ghosh, P, Kufareva, I. | Deposit date: | 2018-09-17 | Release date: | 2019-07-31 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural basis for GPCR-independent activation of heterotrimeric Gi proteins. Proc.Natl.Acad.Sci.USA, 116, 2019
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8CPX
| Human apoferritin after 488 nm laser exposure in presence of rsEGFP2 | Descriptor: | Ferritin heavy chain, N-terminally processed, MAGNESIUM ION, ... | Authors: | Last, M.G.F, Noteborn, W.E.M, Sharp, T.H. | Deposit date: | 2023-03-03 | Release date: | 2023-03-15 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (1.76 Å) | Cite: | Super-resolution fluorescence imaging of cryosamples does not limit achievable resolution in cryoEM. J.Struct.Biol., 215, 2023
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8CPM
| Human apoferritin after 405 nm laser exposure | Descriptor: | Ferritin heavy chain, N-terminally processed, MAGNESIUM ION, ... | Authors: | Last, M.G.F, Noteborn, W.E.M, Sharp, T.H. | Deposit date: | 2023-03-03 | Release date: | 2023-03-15 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (1.81 Å) | Cite: | Super-resolution fluorescence imaging of cryosamples does not limit achievable resolution in cryoEM. J.Struct.Biol., 215, 2023
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7Q5I
| A glucose-based molecular rotor probes the catalytic site of glycogen phosphorylase. | Descriptor: | 2-cyano-3-[4-(dimethylamino)phenyl]-~{N}-[(2~{R},3~{R},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]propanamide, BETA-MERCAPTOETHANOL, CARBONATE ION, ... | Authors: | Neofytos, D.D, Chrysina, E.D. | Deposit date: | 2021-11-03 | Release date: | 2022-03-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A glucose-based molecular rotor inhibitor of glycogen phosphorylase as a probe of cellular enzymatic function. Org.Biomol.Chem., 20, 2022
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8CPU
| Human apoferritin after 561 nm laser exposure | Descriptor: | Ferritin heavy chain, N-terminally processed, MAGNESIUM ION, ... | Authors: | Last, M.G.F, Noteborn, W.E.M, Sharp, T.H. | Deposit date: | 2023-03-03 | Release date: | 2023-03-15 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (1.76 Å) | Cite: | Super-resolution fluorescence imaging of cryosamples does not limit achievable resolution in cryoEM. J.Struct.Biol., 215, 2023
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8CPV
| Human apoferritin | Descriptor: | Ferritin heavy chain, N-terminally processed, MAGNESIUM ION, ... | Authors: | Last, M.G.F, Noteborn, W.E.M, Sharp, T.H. | Deposit date: | 2023-03-03 | Release date: | 2023-03-15 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (1.76 Å) | Cite: | Super-resolution fluorescence imaging of cryosamples does not limit achievable resolution in cryoEM. J.Struct.Biol., 215, 2023
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8CPS
| Human apoferritin | Descriptor: | Ferritin heavy chain, N-terminally processed, MAGNESIUM ION, ... | Authors: | Last, M.G.F, Noteborn, W.E.M, Sharp, T.H. | Deposit date: | 2023-03-03 | Release date: | 2023-03-15 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (1.82 Å) | Cite: | Super-resolution fluorescence imaging of cryosamples does not limit achievable resolution in cryoEM. J.Struct.Biol., 215, 2023
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8CPW
| Human apoferritin after 405 nm + 488 nm laser exposure in presence of rsEGFP2 | Descriptor: | Ferritin heavy chain, N-terminally processed, MAGNESIUM ION, ... | Authors: | Last, M.G.F, Noteborn, W.E.M, Sharp, T.H. | Deposit date: | 2023-03-03 | Release date: | 2023-03-15 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (1.79 Å) | Cite: | Super-resolution fluorescence imaging of cryosamples does not limit achievable resolution in cryoEM. J.Struct.Biol., 215, 2023
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5LHS
| The ligand free catalytic domain of murine urokinase-type plasminogen activator | Descriptor: | NICKEL (II) ION, SULFATE ION, Urokinase-type plasminogen activator | Authors: | Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P.J, Andreasen, P.A. | Deposit date: | 2016-07-12 | Release date: | 2017-06-28 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.047 Å) | Cite: | Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator. Sci Rep, 7, 2017
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8CPT
| Human apoferritin after 488 nm laser exposure | Descriptor: | Ferritin heavy chain, N-terminally processed, MAGNESIUM ION, ... | Authors: | Last, M.G.F, Noteborn, W.E.M, Sharp, T.H. | Deposit date: | 2023-03-03 | Release date: | 2023-03-15 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (1.79 Å) | Cite: | Super-resolution fluorescence imaging of cryosamples does not limit achievable resolution in cryoEM. J.Struct.Biol., 215, 2023
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5EST
| Crystallographic analysis of the inhibition of porcine pancreatic elastase by a peptidyl boronic acid: structure of a reaction intermediate | Descriptor: | CALCIUM ION, ELASTASE, N~2~-[(benzyloxy)carbonyl]-N-[(1R,2S)-1-(dihydroxyboranyl)-2-methylbutyl]-L-alaninamide, ... | Authors: | Takahashi, L.H, Radhakrishnan, R, Rosenfieldjunior, R.E, Meyerjunior, E.F. | Deposit date: | 1989-05-15 | Release date: | 1992-04-15 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | Crystallographic analysis of the inhibition of porcine pancreatic elastase by a peptidyl boronic acid: structure of a reaction intermediate. Biochemistry, 28, 1989
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7N11
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