4XRA

Salmonella typhimurium AhpC T43S mutant

Summary for 4XRA

• Entry DOI: 10.2210/pdb4xra/pdb
• Related: 1YEP 4MA9 4XRD
• Descriptor: Alkyl hydroperoxide reductase subunit C, CHLORIDE ION, POTASSIUM ION, ... (5 entities in total)
• Functional Keywords: peroxiredoxin, ff, prxi, conformation, oxidoreductase
• Biological source: Salmonella enterica subsp. enterica serovar Typhimurium
• Total number of polymer chains: 5
• Total formula weight: 103668.24

Authors

Perkins, A.,Brereton, A.E.,Nelson, K.,Parsonage, D.,Poole, L.,Karplus, P.A. (deposition date: 2015-01-20, release date: 2016-01-20, Last modification date: 2023-09-27)

Primary citation

Nelson, K.J.,Perkins, A.,Van Swearingen, A.E.D.,Hartman, S.,Brereton, A.E.,Parsonage, D.,Salsbury Jr., F.R.,Karplus, P.A.,Poole, L.B.
Experimentally Dissecting the Origins of Peroxiredoxin Catalysis.
Antioxid.Redox Signal., 28:521-536, 2018

PubMed Abstract: Peroxiredoxins (Prxs) are ubiquitous cysteine-based peroxidases involved in oxidant defense and signal transduction. Despite much study, the precise roles of conserved residues remain poorly defined. In this study, we carried out extensive functional and structural characterization of 10 variants of such residues in a model decameric bacterial Prx.

PubMed: 28375740
DOI: 10.1089/ars.2016.6922

Experimental method

X-RAY DIFFRACTION (1.75 Å)