8TNP
 
 | | Cryo-EM structure of DDB1dB:CRBN:Pomalidomide:SD40 | | 分子名称: | DNA damage-binding protein 1, Maltose/maltodextrin-binding periplasmic protein,SD40, Protein cereblon, ... | | 著者 | Roy Burman, S.S, Hunkeler, M, Fischer, E.S. | | 登録日 | 2023-08-02 | | 公開日 | 2024-03-13 | | 最終更新日 | 2024-04-03 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Continuous evolution of compact protein degradation tags regulated by selective molecular glues.
Science, 383, 2024
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4QCI
 | | PDGF-B blocking antibody bound to PDGF-BB | | 分子名称: | Platelet-derived growth factor subunit B, anti-PDGF-BB antibody - Light Chain, anti-PDGF-BB antibody - Heavy chain | | 著者 | Kuai, J, Mosyak, L, Tam, M, LaVallie, E, Pullen, N, Carven, G. | | 登録日 | 2014-05-12 | | 公開日 | 2015-03-11 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Characterization of Binding Mode of Action of a Blocking Anti-Platelet-Derived Growth Factor (PDGF)-B Monoclonal Antibody, MOR8457, Reveals Conformational Flexibility and Avidity Needed for PDGF-BB To Bind PDGF Receptor-beta.
Biochemistry, 54, 2015
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8TNQ
 | | Cryo-EM structure of DDB1dB:CRBN:PT-179:SD40, conformation 1 | | 分子名称: | 2-[(3S)-2,6-dioxopiperidin-3-yl]-5-(morpholin-4-yl)-1H-isoindole-1,3(2H)-dione, DNA damage-binding protein 1, Maltose/maltodextrin-binding periplasmic protein,SD40, ... | | 著者 | Roy Burman, S.S, Hunkeler, M, Fischer, E.S. | | 登録日 | 2023-08-02 | | 公開日 | 2024-03-13 | | 最終更新日 | 2024-04-03 | | 実験手法 | ELECTRON MICROSCOPY (2.41 Å) | | 主引用文献 | Continuous evolution of compact protein degradation tags regulated by selective molecular glues.
Science, 383, 2024
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8I40
 | | Crystal structure of ASCT from Trypanosoma brucei in complex with CoA. | | 分子名称: | ACETATE ION, CALCIUM ION, COENZYME A, ... | | 著者 | Mochizuki, K, Inaoka, D.K, Fukuda, K, Kurasawa, H, Iyoda, K, Nakai, U, Harada, S, Balogun, E.O, Mazet, M, Millerioux, Y, Bringaud, F, Boshart, M, Hirayama, K, Kita, K, Shiba, T. | | 登録日 | 2023-01-18 | | 公開日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | | 主引用文献 | Crystal structure of ligand complexes of ASCT from Trypanosoma brucei and molecular mechanism in comparison with mammalian SCOT.
To Be Published
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8TFU
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8PYH
 | | Crystal structure of the Orange Carotenoid Protein 2 (OCP2) from Crinalium epipsammum PCC 9333 | | 分子名称: | ACETATE ION, Orange carotenoid-binding protein, beta,beta-caroten-4-one | | 著者 | Boyko, K.M, Varfolomeeva, L.A, Slonimskiy, Y.B, Maksimov, E.G, Popov, V.O, Sluchanko, N.N. | | 登録日 | 2023-07-25 | | 公開日 | 2024-01-03 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural framework for the understanding spectroscopic and functional signatures of the cyanobacterial Orange Carotenoid Protein families.
Int.J.Biol.Macromol., 254, 2024
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1QCB
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8PZK
 | | Crystal structure of the Orange Carotenoid Protein 2 (OCP2) from Gloeocapsa sp. PCC 7428 | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, AZIDE ION, GLYCEROL, ... | | 著者 | Boyko, K.M, Varfolomeeva, L.A, Slonimskiy, Y.B, Maksimov, E.G, Popov, V.O, Sluchanko, N.N. | | 登録日 | 2023-07-27 | | 公開日 | 2024-01-03 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural framework for the understanding spectroscopic and functional signatures of the cyanobacterial Orange Carotenoid Protein families.
Int.J.Biol.Macromol., 254, 2024
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5IY8
 | | Human holo-PIC in the initial transcribing state | | 分子名称: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB10, DNA-directed RNA polymerase II subunit RPB11-a, ... | | 著者 | He, Y, Yan, C, Fang, J, Inouye, C, Tjian, R, Ivanov, I, Nogales, E. | | 登録日 | 2016-03-24 | | 公開日 | 2016-05-18 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (7.9 Å) | | 主引用文献 | Near-atomic resolution visualization of human transcription promoter opening.
Nature, 533, 2016
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5F7Y
 | | Blood group antigen binding adhesin BabA of Helicobacter pylori strain 17875 in complex with blood group A type-1 hexasaccharide | | 分子名称: | Adhesin binding fucosylated histo-blood group antigen, Nanobody Nb-ER19, alpha-L-fucopyranose-(1-2)-[2-acetamido-2-deoxy-alpha-D-galactopyranose-(1-3)]beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose | | 著者 | Moonens, K, Gideonsson, P, Subedi, S, Romao, E, Oscarson, S, Muyldermans, S, Boren, T, Remaut, H. | | 登録日 | 2015-12-08 | | 公開日 | 2016-01-20 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | | 主引用文献 | Structural Insights into Polymorphic ABO Glycan Binding by Helicobacter pylori.
Cell Host Microbe, 19, 2016
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5IZJ
 | | Complex of PKA with the bisubstrate protein kinase inhibitor ARC-1411 | | 分子名称: | 4-(piperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine, 47P-AZ1-DAR-DAR, 47P-AZ1-DAR-DAR-DAR, ... | | 著者 | Pflug, A, Enkvist, E, Uri, A, Engh, R.A. | | 登録日 | 2016-03-25 | | 公開日 | 2016-07-20 | | 最終更新日 | 2019-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Bifunctional Ligands for Inhibition of Tight-Binding Protein-Protein Interactions.
Bioconjug.Chem., 27, 2016
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8TLS
 | | Crystal structure of Shewanella benthica Group 1 truncated hemoglobin C51S C71S Y108A variant | | 分子名称: | CYANIDE ION, Group 1 truncated hemoglobin, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Schultz, T.D, Martinez, J.E, Siegler, M.A, Schlessman, J.L, Lecomte, J.T.J. | | 登録日 | 2023-07-27 | | 公開日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Crystal structure of Shewanella benthica Group 1 truncated hemoglobin C51S C71S Y108A variant
To Be Published
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5ZWL
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7TT9
 | | Crystal structure of Shewanella benthica Group 1 truncated hemoglobin C51S C71S Y34F variant | | 分子名称: | Group 1 truncated hemoglobin, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Martinez, J.E, Liu, K, Siegler, M.A, Schlessman, J.L, Lecomte, J.T.J. | | 登録日 | 2022-02-01 | | 公開日 | 2022-02-16 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structure of Shewanella benthica Group 1 truncated hemoglobin C51S C71S Y34F variant
To Be Published
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8PHE
 | | ACAD9-WT in complex with ECSIT-CTER | | 分子名称: | Complex I assembly factor ACAD9, mitochondrial, Evolutionarily conserved signaling intermediate in Toll pathway | | 著者 | McGregor, L, Acajjaoui, S, Desfosses, A, Saidi, M, Bacia-Verloop, M, Schwarz, J.J, Juyoux, P, Von Velsen, J, Bowler, M.W, McCarthy, A, Kandiah, E, Gutsche, I, Soler-Lopez, M. | | 登録日 | 2023-06-19 | | 公開日 | 2024-01-24 | | 最終更新日 | 2024-01-31 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | The assembly of the Mitochondrial Complex I Assembly complex uncovers a redox pathway coordination.
Nat Commun, 14, 2023
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5IY6
 | | Human holo-PIC in the closed state | | 分子名称: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB10, DNA-directed RNA polymerase II subunit RPB11-a, ... | | 著者 | He, Y, Yan, C, Fang, J, Inouye, C, Tjian, R, Ivanov, I, Nogales, E. | | 登録日 | 2016-03-24 | | 公開日 | 2016-05-18 | | 最終更新日 | 2019-11-20 | | 実験手法 | ELECTRON MICROSCOPY (7.2 Å) | | 主引用文献 | Near-atomic resolution visualization of human transcription promoter opening.
Nature, 533, 2016
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1QO1
 | | Molecular Architecture of the Rotary Motor in ATP Synthase from Yeast Mitochondria | | 分子名称: | ATP SYNTHASE ALPHA CHAIN, ATP SYNTHASE BETA CHAIN, ATP SYNTHASE DELTA CHAIN, ... | | 著者 | Stock, D, Leslie, A.G.W, Walker, J.E. | | 登録日 | 1999-11-01 | | 公開日 | 1999-11-04 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (3.9 Å) | | 主引用文献 | Molecular Architecture of the Rotary Motor in ATP Synthase
Science, 286, 1999
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8TKP
 | | Structure of the C. elegans TMC-2 complex | | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Clark, S, Jeong, H, Goehring, A, Posert, R, Gouaux, E. | | 登録日 | 2023-07-25 | | 公開日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | The structure of the Caenorhabditis elegans TMC-2 complex suggests roles of lipid-mediated subunit contacts in mechanosensory transduction.
Proc.Natl.Acad.Sci.USA, 121, 2024
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5BMM
 | | Src in complex with DNA-templated macrocyclic inhibitor MC25b | | 分子名称: | Proto-oncogene tyrosine-protein kinase Src, macrocyclic inhibitor MC25b | | 著者 | Georghiou, G, Guja, K.E, Aleem, S, Kleiner, R.E, Liu, D.R, Miller, W.T, Garcia-Diaz, M, Seeliger, M.A. | | 登録日 | 2015-05-22 | | 公開日 | 2016-09-21 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural and Biochemical Basis for Intracellular Kinase Inhibition by Src-specific Peptidic Macrocycles.
Cell Chem Biol, 23, 2016
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4QGN
 | | Human acireductone dioxygenase with iron ion and L-methionine in active center | | 分子名称: | 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, ACETATE ION, CHLORIDE ION, ... | | 著者 | Milaczewska, A.M, Chruszcz, M, Petkowski, J.J, Niedzialkowska, E, Minor, W, Borowski, T. | | 登録日 | 2014-05-23 | | 公開日 | 2015-05-27 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | | 主引用文献 | On the Structure and Reaction Mechanism of Human Acireductone Dioxygenase.
Chemistry, 24, 2018
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5BOP
 | | Crystal structure of the artificial nanobody octarellinV.1 complex | | 分子名称: | Nanobody, Octarellin V.1 | | 著者 | Figueroa, M, Sleutel, M, Pardon, E, Steyaert, J, Martial, J.A, van de Weerdt, C. | | 登録日 | 2015-05-27 | | 公開日 | 2016-05-25 | | 最終更新日 | 2016-06-08 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | The unexpected structure of the designed protein Octarellin V.1 forms a challenge for protein structure prediction tools.
J.Struct.Biol., 195, 2016
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3KR3
 | | Crystal structure of IGF-II antibody complex | | 分子名称: | 1,2-ETHANEDIOL, Insulin-like growth factor II, antibody-Fab (heavy chain), ... | | 著者 | Peat, T.S, Newman, J, Adams, T.E. | | 登録日 | 2009-11-17 | | 公開日 | 2010-06-16 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | A human monoclonal antibody against insulin-like growth factor-II blocks the growth of human hepatocellular carcinoma cell lines in vitro and in vivo.
Mol.Cancer Ther., 9, 2010
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1TUG
 | | Aspartate Transcarbamoylase Catalytic Chain Mutant E50A Complex with Phosphonoacetamide, Malonate, and Cytidine-5-Prime-Triphosphate (CTP) | | 分子名称: | Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, CYTIDINE-5'-TRIPHOSPHATE, ... | | 著者 | Stieglitz, K, Stec, B, Baker, D.P, Kantrowitz, E.R. | | 登録日 | 2004-06-24 | | 公開日 | 2004-07-20 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Monitoring the Transition from the T to the R State in E.coli Aspartate Transcarbamoylase by X-ray Crystallography: Crystal Structures of the E50A Mutant Enzyme in Four Distinct Allosteric States.
J.Mol.Biol., 341, 2004
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5IY9
 | | Human holo-PIC in the initial transcribing state (no IIS) | | 分子名称: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB10, DNA-directed RNA polymerase II subunit RPB11-a, ... | | 著者 | He, Y, Yan, C, Fang, J, Inouye, C, Tjian, R, Ivanov, I, Nogales, E. | | 登録日 | 2016-03-24 | | 公開日 | 2016-05-18 | | 最終更新日 | 2019-11-20 | | 実験手法 | ELECTRON MICROSCOPY (6.3 Å) | | 主引用文献 | Near-atomic resolution visualization of human transcription promoter opening.
Nature, 533, 2016
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3ZEU
 | | Structure of a Salmonella typhimurium YgjD-YeaZ heterodimer bound to ATPgammaS | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, MAGNESIUM ION, ... | | 著者 | Nichols, C.E, Lamb, H.K, Thompson, P, El Omari, K, Lockyer, M, Charles, I, Hawkins, A.R, Stammers, D.K. | | 登録日 | 2012-12-07 | | 公開日 | 2013-03-20 | | 最終更新日 | 2017-03-29 | | 実験手法 | X-RAY DIFFRACTION (1.653 Å) | | 主引用文献 | Crystal Structure of the Dimer of Two Essential Salmonella Typhimurium Proteins, Ygjd & Yeaz and Calorimetric Evidence for the Formation of a Ternary Ygjd-Yeaz-Yjee Complex.
Protein Sci., 22, 2013
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