4QZ5
| yCP beta5-A49T-mutant in complex with ONX 0914 | 分子名称: | 1,2,4-trideoxy-4-methyl-2-{[N-(morpholin-4-ylacetyl)-L-alanyl-O-methyl-L-tyrosyl]amino}-1-phenyl-D-xylitol, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, ... | 著者 | Huber, E.M, Heinemeyer, W, Groll, M. | 登録日 | 2014-07-27 | 公開日 | 2015-02-04 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Bortezomib-Resistant Mutant Proteasomes: Structural and Biochemical Evaluation with Carfilzomib and ONX 0914. Structure, 23, 2015
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7MEZ
| Structure of the phosphoinositide 3-kinase p110 gamma (PIK3CG) p101 (PIK3R5) complex | 分子名称: | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, Phosphoinositide 3-kinase regulatory subunit 5 | 著者 | Burke, J.E, Dalwadi, U, Rathinaswamy, M.K, Yip, C.K. | 登録日 | 2021-04-08 | 公開日 | 2021-07-14 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | 主引用文献 | Structure of the phosphoinositide 3-kinase (PI3K) p110 gamma-p101 complex reveals molecular mechanism of GPCR activation. Sci Adv, 7, 2021
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2HOT
| Phage selected homeodomain bound to modified DNA | 分子名称: | 3-PROP-2-YN-1-YL-1,3-OXAZOLIDIN-2-ONE, 5'-D(*AP*TP*CP*CP*GP*GP*GP*GP*AP*TP*TP*AP*CP*AP*TP*GP*GP*CP*AP*AP*A)-3', 5'-D(*TP*TP*TP*TP*GP*CP*CP*AP*TP*GP*TP*AP*AP*TP*CP*CP*CP*CP*GP*GP*A)-3', ... | 著者 | Feldman, M.E, Simon, M.D, Shokat, K.M. | 登録日 | 2006-07-16 | 公開日 | 2006-12-12 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Structure and properties of a re-engineered homeodomain protein-DNA interface. Acs Chem.Biol., 1, 2006
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5IH9
| MELK in complex with NVS-MELK8A | 分子名称: | 1-methyl-4-[4-(4-{3-[(piperidin-4-yl)methoxy]pyridin-4-yl}-1H-pyrazol-1-yl)phenyl]piperazine, Maternal embryonic leucine zipper kinase | 著者 | Sprague, E.R, Puleo, D.E. | 登録日 | 2016-02-29 | 公開日 | 2016-06-01 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight. J.Med.Chem., 59, 2016
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4QWG
| yCP beta5-A49V mutant in complex with carfilzomib | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Huber, E.M, Heinemeyer, W, Groll, M. | 登録日 | 2014-07-16 | 公開日 | 2015-02-04 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Bortezomib-Resistant Mutant Proteasomes: Structural and Biochemical Evaluation with Carfilzomib and ONX 0914. Structure, 23, 2015
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5IIK
| Crystal structure of the post-catalytic nick complex of DNA polymerase lambda with a templating 8-oxo-dG and incorporated dC | 分子名称: | CITRIC ACID, DNA (5'-D(*CP*AP*GP*TP*AP*CP*T)-3'), DNA (5'-D(*CP*GP*GP*CP*AP*(8OG)P*TP*AP*CP*TP*G)-3'), ... | 著者 | Burak, M.J, Guja, K.E, Garcia-Diaz, M. | 登録日 | 2016-03-01 | 公開日 | 2016-08-17 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.982 Å) | 主引用文献 | A fidelity mechanism in DNA polymerase lambda promotes error-free bypass of 8-oxo-dG. Embo J., 35, 2016
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2HQA
| Crystal structure of the catalytic alpha subunit of E. Coli replicative DNA polymerase III | 分子名称: | DNA polymerase III alpha subunit, PHOSPHATE ION | 著者 | Lamers, M.H, Georgescu, R.E, Lee, S.G, O'Donnell, M, Kuriyan, J. | 登録日 | 2006-07-18 | 公開日 | 2006-09-19 | 最終更新日 | 2017-10-18 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal Structure of the Catalytic alpha Subunit of E. coli Replicative DNA Polymerase III. Cell(Cambridge,Mass.), 126, 2006
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4EOI
| Thr 160 phosphorylated CDK2 K89D, Q131E - human cyclin A3 complex with the inhibitor RO3306 | 分子名称: | (5E)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one, Cyclin-A2, Cyclin-dependent kinase 2, ... | 著者 | Echalier, A, Cot, E, Camasses, A, Hodimont, E, Hoh, F, Sheinerman, F, Krasinska, L, Fisher, D. | 登録日 | 2012-04-14 | 公開日 | 2013-02-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity. Chem.Biol., 19, 2012
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6VB8
| Crystal structure of a lectin from Canavalia brasiliensis seed (ConBr) complexed with indole-3-acetic acid | 分子名称: | 1H-INDOL-3-YLACETIC ACID, CALCIUM ION, CHLORIDE ION, ... | 著者 | Bezerra, E.H.S, Queiroz, P.P, da Silva, F.M.S, Girao, M.S, Sales, M.V, Paiva, C.P.S, Freire, V.N, Rocha, B.A.M. | 登録日 | 2019-12-18 | 公開日 | 2020-12-23 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural insights into phytohormone interaction to plant lectin ConBr To Be Published
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4EOP
| Thr 160 phosphorylated CDK2 Q131E - human cyclin A3 complex with the inhibitor RO3306 | 分子名称: | (5E)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one, Cyclin-A2, Cyclin-dependent kinase 2, ... | 著者 | Echalier, A, Cot, E, Camasses, A, Hodimont, E, Hoh, F, Sheinerman, F, Krasinska, L, Fisher, D. | 登録日 | 2012-04-14 | 公開日 | 2013-02-06 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity. Chem.Biol., 19, 2012
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5IK8
| Laminin A2LG45 I-form, G6/7 bound. | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 7-hydroxy-4-methyl-2H-chromen-2-one, ... | 著者 | Briggs, D.C, Hohenester, E, Campbell, K.P. | 登録日 | 2016-03-03 | 公開日 | 2016-08-10 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural basis of laminin binding to the LARGE glycans on dystroglycan. Nat.Chem.Biol., 12, 2016
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1P8R
| Structural and Functional Importance of First-Shell Metal Ligands in the Binuclear Manganese Cluster of Arginase I. | 分子名称: | Arginase 1, CHLORIDE ION, MANGANESE (II) ION, ... | 著者 | Cama, E, Emig, F.A, Ash, D.E, Christianson, D.W. | 登録日 | 2003-05-07 | 公開日 | 2003-06-17 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural and functional importance of first-shell metal ligands in the binuclear
manganese cluster of arginase I Biochemistry, 42, 2003
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2RDP
| The structure of a MarR family protein from Bacillus stearothermophilus | 分子名称: | BETA-MERCAPTOETHANOL, PHOSPHATE ION, SODIUM ION, ... | 著者 | Cuff, M.E, Duggan, E, Dementieva, I, Moy, S, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2007-09-24 | 公開日 | 2007-11-13 | 最終更新日 | 2017-10-25 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | The structure of a MarR family protein from Bacillus stearothermophilus. TO BE PUBLISHED
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6IAL
| Porcine E.coli heat-labile enterotoxin B-pentamer in complex with Lacto-N-neohexaose | 分子名称: | CALCIUM ION, GLYCEROL, Heat-labile enterotoxin B chain, ... | 著者 | Heim, J.B, Heggelund, J.E, Krengel, U. | 登録日 | 2018-11-27 | 公開日 | 2019-02-27 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Specificity ofEscherichia coliHeat-Labile Enterotoxin Investigated by Single-Site Mutagenesis and Crystallography. Int J Mol Sci, 20, 2019
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4QV9
| yCP beta5-C63F mutant | 分子名称: | CHLORIDE ION, MAGNESIUM ION, Probable proteasome subunit alpha type-7, ... | 著者 | Huber, E.M, Heinemeyer, W, Groll, M. | 登録日 | 2014-07-14 | 公開日 | 2015-02-04 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Bortezomib-Resistant Mutant Proteasomes: Structural and Biochemical Evaluation with Carfilzomib and ONX 0914. Structure, 23, 2015
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6UWZ
| Cryo-EM structure of Torpedo acetylcholine receptor in complex with alpha-bungarotoxin | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholine receptor subunit alpha, ... | 著者 | Rahman, M.M, Teng, J, Worrell, B.T, Noveillo, C.M, Lee, M, Karlin, A, Stowell, M, Hibbs, R.E. | 登録日 | 2019-11-06 | 公開日 | 2020-04-15 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (2.69 Å) | 主引用文献 | Structure of the Native Muscle-type Nicotinic Receptor and Inhibition by Snake Venom Toxins. Neuron, 106, 2020
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4QW4
| yCP in complex with carfilzomib | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Huber, E.M, Heinemeyer, W, Groll, M. | 登録日 | 2014-07-16 | 公開日 | 2015-02-04 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Bortezomib-Resistant Mutant Proteasomes: Structural and Biochemical Evaluation with Carfilzomib and ONX 0914. Structure, 23, 2015
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4QWU
| yCP beta5-C52F mutant in complex with bortezomib | 分子名称: | CHLORIDE ION, MAGNESIUM ION, N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE, ... | 著者 | Huber, E.M, Heinemeyer, W, Groll, M. | 登録日 | 2014-07-17 | 公開日 | 2015-02-04 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Bortezomib-Resistant Mutant Proteasomes: Structural and Biochemical Evaluation with Carfilzomib and ONX 0914. Structure, 23, 2015
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4EOM
| Thr 160 phosphorylated CDK2 H84S, Q85M, Q131E - human cyclin A3 complex with ATP | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cyclin-A2, Cyclin-dependent kinase 2, ... | 著者 | Echalier, A, Cot, E, Camasses, A, Hodimont, E, Hoh, F, Sheinerman, F, Krasinska, L, Fisher, D. | 登録日 | 2012-04-14 | 公開日 | 2013-02-06 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity. Chem.Biol., 19, 2012
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4QZX
| yCP beta5-C63F mutant in complex with the epoxyketone inhibitor ONX 0914 | 分子名称: | 1,2,4-trideoxy-4-methyl-2-{[N-(morpholin-4-ylacetyl)-L-alanyl-O-methyl-L-tyrosyl]amino}-1-phenyl-D-xylitol, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, ... | 著者 | Huber, E.M, Heinemeyer, W, Groll, M. | 登録日 | 2014-07-29 | 公開日 | 2015-02-04 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Bortezomib-Resistant Mutant Proteasomes: Structural and Biochemical Evaluation with Carfilzomib and ONX 0914. Structure, 23, 2015
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3UAJ
| Crystal structure of the envelope glycoprotein ectodomain from dengue virus serotype 4 in complex with the fab fragment of the chimpanzee monoclonal antibody 5H2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain, monoclonal antibody 5H2, ... | 著者 | Cockburn, J.J.B, Stura, E.A, Navarro-Sanchez, M.E, Rey, F.A. | 登録日 | 2011-10-21 | 公開日 | 2011-12-14 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3.232 Å) | 主引用文献 | Structural insights into the neutralization mechanism of a higher primate antibody against dengue virus. Embo J., 31, 2012
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7MOP
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7M2G
| INTERLEUKIN-2 (human) mutant P65K, C125S | 分子名称: | GLYCEROL, Interleukin-2, SULFATE ION | 著者 | Ptacin, J.L, Milla, M.E, Steinbacher, S, Maskos, K, Thomsen, M. | 登録日 | 2021-03-16 | 公開日 | 2021-08-04 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism. Nat Commun, 12, 2021
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2QOD
| Human EphA3 kinase and juxtamembrane region, Y602F mutant | 分子名称: | Ephrin receptor | 著者 | Davis, T, Walker, J.R, Newman, E.M, Mackenzie, F, Butler-Cole, C, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | 登録日 | 2007-07-20 | 公開日 | 2007-08-21 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | 主引用文献 | Autoregulation by the Juxtamembrane Region of the Human Ephrin Receptor Tyrosine Kinase A3 (EphA3). Structure, 16, 2008
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2J4F
| Torpedo acetylcholinesterase - Hg heavy-atom derivative | 分子名称: | ACETYLCHOLINESTERASE, MERCURY (II) ION | 著者 | Kreimer, D.I, Dolginova, E.A, Raves, M, Sussman, J.L, Silman, I, Weiner, L. | 登録日 | 2006-08-30 | 公開日 | 2006-09-05 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | A Metastable State of Torpedo Californica Acetylcholinesterase Generated by Modification with Organomercurials Biochemistry, 33, 1994
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