4EOP

Thr 160 phosphorylated CDK2 Q131E - human cyclin A3 complex with the inhibitor RO3306

Summary for 4EOP

Related4EOI 4EOJ 4EOK 4EOL 4EOM 4EON 4EOO 4EOQ 4EOR 4EOS
DescriptorCyclin-dependent kinase 2, Cyclin-A2, (5E)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one, ... (6 entities in total)
Functional Keywordsprotein kinase, cell cycle, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm, cytoskeleton, centrosome P24941
Nucleus P20248
Total number of polymer chains4
Total molecular weight128455.03
Authors
Echalier, A.,Cot, E.,Camasses, A.,Hodimont, E.,Hoh, F.,Sheinerman, F.,Krasinska, L.,Fisher, D. (deposition date: 2012-04-14, release date: 2013-02-06)
Primary citation
Echalier, A.,Cot, E.,Camasses, A.,Hodimont, E.,Hoh, F.,Jay, P.,Sheinerman, F.,Krasinska, L.,Fisher, D.
An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity.
Chem.Biol., 19:1028-1040, 2012
PubMed: 22921070 (PDB entries with the same primary citation)
DOI: 10.1016/j.chembiol.2012.06.015
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.99 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.24070.4%3.6%11.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report