5IH9
MELK in complex with NVS-MELK8A
Summary for 5IH9
Entry DOI | 10.2210/pdb5ih9/pdb |
Related | 5HIA 5HIC 5IH8 |
Descriptor | Maternal embryonic leucine zipper kinase, 1-methyl-4-[4-(4-{3-[(piperidin-4-yl)methoxy]pyridin-4-yl}-1H-pyrazol-1-yl)phenyl]piperazine (3 entities in total) |
Functional Keywords | kinase uba domain inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane ; Peripheral membrane protein : Q14680 |
Total number of polymer chains | 1 |
Total formula weight | 39391.64 |
Authors | Sprague, E.R.,Puleo, D.E. (deposition date: 2016-02-29, release date: 2016-06-01, Last modification date: 2024-03-06) |
Primary citation | Toure, B.B.,Giraldes, J.,Smith, T.,Sprague, E.R.,Wang, Y.,Mathieu, S.,Chen, Z.,Mishina, Y.,Feng, Y.,Yan-Neale, Y.,Shakya, S.,Chen, D.,Meyer, M.,Puleo, D.,Brazell, J.T.,Straub, C.,Sage, D.,Wright, K.,Yuan, Y.,Chen, X.,Duca, J.,Kim, S.,Tian, L.,Martin, E.,Hurov, K.,Shao, W. Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight. J.Med.Chem., 59:4711-4723, 2016 Cited by PubMed: 27187609DOI: 10.1021/acs.jmedchem.6b00052 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.79 Å) |
Structure validation
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