5IH9
MELK in complex with NVS-MELK8A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Maternal embryonic leucine zipper kinase | polymer | 335 | 38959.1 | 1 | UniProt (Q14680) Pfam (PF00069) Pfam (PF21594) | Homo sapiens (Human) | hMELK,Protein kinase Eg3,pEg3 kinase,Protein kinase PK38,hPK38,Tyrosine-protein kinase MELK |
| 2 | B (A) | 1-methyl-4-[4-(4-{3-[(piperidin-4-yl)methoxy]pyridin-4-yl}-1H-pyrazol-1-yl)phenyl]piperazine | non-polymer | 432.6 | 1 | Chemie (6BF) | |||
| 3 | C (A) | water | water | 18.0 | 314 | Chemie (HOH) |
Sequence modifications
A: 3 - 330 (UniProt: Q14680)
| PDB | External Database | Details |
|---|---|---|
| Met 2 | - | initiating methionine |
| His 331 | - | expression tag |
| His 332 | - | expression tag |
| His 333 | - | expression tag |
| His 334 | - | expression tag |
| His 335 | - | expression tag |
| His 336 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 38959.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 432.6 | |
| All* | Total formula weight | 39391.6 |
