2HOT

Phage selected homeodomain bound to modified DNA

Summary for 2HOT

• Entry DOI: 10.2210/pdb2hot/pdb
• Related: 2HDD 2HOS
• Descriptor: 5'-D(*TP*TP*TP*TP*GP*CP*CP*AP*TP*GP*TP*AP*AP*TP*CP*CP*CP*CP*GP*GP*A)-3', 5'-D(*AP*TP*CP*CP*GP*GP*GP*GP*AP*TP*TP*AP*CP*AP*TP*GP*GP*CP*AP*AP*A)-3', Segmentation polarity homeobox protein engrailed, ... (6 entities in total)
• Functional Keywords: homeodomain, phage display, transcription-dna complex, transcription/dna
• Biological source: Drosophila melanogaster (fruit fly); More
• Cellular location: Nucleus : P02836
• Total number of polymer chains: 4
• Total formula weight: 28227.71

Authors

Feldman, M.E.,Simon, M.D.,Shokat, K.M. (deposition date: 2006-07-16, release date: 2006-12-12, Last modification date: 2024-02-14)

• Primary citation: Simon, M.D.,Feldman, M.E.,Rauh, D.,Maris, A.E.,Wemmer, D.E.,Shokat, K.M.; Structure and properties of a re-engineered homeodomain protein-DNA interface.; Acs Chem.Biol., 1:755-760, 2006; PubMed: 17240973; DOI: 10.1021/cb6003756

Experimental method

X-RAY DIFFRACTION (2.19 Å)