5EWN
 
 | | Crystal structure of the human astrovirus 1 capsid protein core domain at 2.6 A resolution | | 分子名称: | CHLORIDE ION, Structural protein | | 著者 | York, R.L, Yousefi, P.A, Bogdanoff, W, Haile, S, Tripathi, S, DuBois, R.M. | | 登録日 | 2015-11-20 | | 公開日 | 2015-12-23 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.602 Å) | | 主引用文献 | Structural, Mechanistic, and Antigenic Characterization of the Human Astrovirus Capsid.
J.Virol., 90, 2015
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7UYI
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8SJ9
 | | Crystal structure of the H1 hemagglutinin COBRA X6 | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Dzimianski, J.V, DuBois, R.M. | | 登録日 | 2023-04-17 | | 公開日 | 2024-05-01 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | | 主引用文献 | Structural basis for the broad antigenicity of the computationally optimized influenza hemagglutinin X6.
Structure, 32, 2024
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8TN8
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8TUI
 | | Crystal structure of Fab-Lirilumab bound to KIR2DL3 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Killer cell immunoglobulin-like receptor 2DL3, Lirilumab Fab Heavy Chain, ... | | 著者 | Lorig-Roach, N, DuBois, R.M. | | 登録日 | 2023-08-16 | | 公開日 | 2023-12-06 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Structural basis for the activity and specificity of the immune checkpoint inhibitor lirilumab.
Sci Rep, 14, 2024
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8UFN
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8UFO
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5KOV
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4B3V
 | | Crystal structure of the Rubella virus glycoprotein E1 in its post-fusion form crystallized in presence of 20mM of Calcium Acetate | | 分子名称: | 2-acetamido-2-deoxy-beta-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... | | 著者 | Vaney, M.C, DuBois, R.M, Tortorici, M.A, Rey, F.A. | | 登録日 | 2012-07-26 | | 公開日 | 2013-01-09 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | | 主引用文献 | Functional and Evolutionary Insight from the Crystal Structure of Rubella Virus Protein E1.
Nature, 493, 2013
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5W1N
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9CQD
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5WNB
 | | Structure of antibody 3D3 bound to the linear epitope of RSV G | | 分子名称: | ACETIC ACID, Major surface glycoprotein G, ZINC ION, ... | | 著者 | Fedechkin, S.O, George, N.L, Wolff, J.T, Kauvar, L.M, DuBois, R.M. | | 登録日 | 2017-07-31 | | 公開日 | 2018-03-14 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structures of respiratory syncytial virus G antigen bound to broadly neutralizing antibodies.
Sci Immunol, 3, 2018
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6UVO
 | | Structure of antibody 3G12 bound to the central conserved domain of RSV G | | 分子名称: | 3G12 Fab Heavy chain, 3G12 Fab light chain, Major surface glycoprotein G | | 著者 | Fedechkin, S.O, George, N.L, Nunez Castrejon, A.M, Dillen, J, Kauvar, L.M, DuBois, R.M. | | 登録日 | 2019-11-03 | | 公開日 | 2019-12-18 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Conformational Flexibility in Respiratory Syncytial Virus G Neutralizing Epitopes.
J.Virol., 94, 2020
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5WNA
 | | Structure of antibody 3D3 bound to the central conserved region of RSV G | | 分子名称: | Major surface glycoprotein G, mAb 3D3 Fab heavy chain, mAb 3D3 Fab light chain | | 著者 | Fedechkin, S.O, George, N.L, Wolff, J.T, Kauvar, L.M, DuBois, R.M. | | 登録日 | 2017-07-31 | | 公開日 | 2018-03-14 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structures of respiratory syncytial virus G antigen bound to broadly neutralizing antibodies.
Sci Immunol, 3, 2018
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5KOU
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9CQA
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9CBN
 | | HAstV1 spike in complex with neutralizing Fabs 3H4 and 3B4 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, HAstV1 neutralizing Fab 3B4 heavy chain, HAstV1 neutralizing Fab 3B4 kappa chain, ... | | 著者 | Lanning, S, DuBois, R.M, Balasco Serrao, V.H. | | 登録日 | 2024-06-19 | | 公開日 | 2024-12-25 | | 最終更新日 | 2025-03-05 | | 実験手法 | ELECTRON MICROSCOPY (3.33 Å) | | 主引用文献 | Discovery of three novel neutralizing antibody epitopes on the human astrovirus capsid spike and mechanistic insights into virus neutralization.
J.Virol., 99, 2025
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5WN9
 | | Structure of antibody 2D10 bound to the central conserved region of RSV G | | 分子名称: | Major surface glycoprotein G, scFv 2D10 | | 著者 | Fedechkin, S.O, George, N.L, Wolff, J.T, Kauvar, L.M, DuBois, R.M. | | 登録日 | 2017-07-31 | | 公開日 | 2018-03-14 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.551 Å) | | 主引用文献 | Structures of respiratory syncytial virus G antigen bound to broadly neutralizing antibodies.
Sci Immunol, 3, 2018
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9CP0
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9CN2
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7ML8
 | | The crystal structure of I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ001023038 | | 分子名称: | 5-hydroxy-N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-6-oxo-2-phenyl-1,6-dihydropyrimidine-4-carboxamide, GLUTAMIC ACID, Hexa Vinylpyrrolidone K15, ... | | 著者 | Cuypers, M.G, Slavish, P.J, Yun, M.K, Dubois, R, Rankovic, Z, White, S.W. | | 登録日 | 2021-04-27 | | 公開日 | 2021-10-27 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | The crystal structure of I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with St Jude compound AC067-19
To Be Published
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7M0N
 | | The crystal structure of wild type PA endonuclease (A/Vietnam/1203/2004) in complex with Raltegravir | | 分子名称: | GLYCEROL, MANGANESE (II) ION, N-(4-fluorobenzyl)-5-hydroxy-1-methyl-2-(1-methyl-1-{[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]amino}ethyl)-6-oxo-1,6-di hydropyrimidine-4-carboxamide, ... | | 著者 | Cuypers, M.G, Slavish, P.J, Yun, M.K, Dubois, R, Rankovic, Z, White, S.W. | | 登録日 | 2021-03-11 | | 公開日 | 2022-03-02 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential.
Eur.J.Med.Chem., 247, 2023
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7RK2
 | | Crystal structure of the human astrovirus serotype 8 capsid spike in complex with scFv 2D9, an astrovirus-neutralizing antibody, at 2.65-A resolution | | 分子名称: | Capsid protein VP25, scFv 2D9 | | 著者 | Meyer, L, Cuellar, C, DuBois, R.M. | | 登録日 | 2021-07-21 | | 公開日 | 2021-10-13 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Structures of Two Human Astrovirus Capsid/Neutralizing Antibody Complexes Reveal Distinct Epitopes and Inhibition of Virus Attachment to Cells.
J.Virol., 96, 2022
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7RK1
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