6D0T
 
 | | De novo design of a fluorescence-activating beta barrel - BB1 | | 分子名称: | BB1 | | 著者 | Dou, J, Vorobieva, A.A, Sheffler, W, Doyle, L.A, Park, H, Bick, M.J, Mao, B, Foight, G.W, Lee, M, Carter, L, Sankaran, B, Ovchinnikov, S, Marcos, E, Huang, P, Vaughan, J.C, Stoddard, B.L, Baker, D. | | 登録日 | 2018-04-10 | | 公開日 | 2018-09-19 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | | 主引用文献 | De novo design of a fluorescence-activating beta-barrel.
Nature, 561, 2018
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4UV4
 | | Crystal structure of anti-FPR Fpro0165 Fab fragment | | 分子名称: | FPRO0165 FAB | | 著者 | Douthwaite, J.A, Sridharan, S, Huntington, C, Marwood, R, Hammersley, J, Hakulinen, J.K, Ek, M, Sjogren, T, Rider, D, Privezentzev, C, Seaman, J.C, Cariuk, P, Knights, V, Young, J, Wilkinson, T, Sleeman, M, Finch, D.K, Lowe, D.C, Vaughan, T.J. | | 登録日 | 2014-08-04 | | 公開日 | 2014-12-24 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3.08 Å) | | 主引用文献 | Affinity Maturation of a Novel Antagonistic Human Monoclonal Antibody with a Long Vh Cdr3 Targeting the Class a Gpcr Formyl-Peptide Receptor 1.
Mabs, 7, 2015
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3BIR
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5BIR
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1BIR
 | | RIBONUCLEASE T1, PHE 100 TO ALA MUTANT COMPLEXED WITH 2' GMP | | 分子名称: | CALCIUM ION, GUANOSINE-2'-MONOPHOSPHATE, RIBONUCLEASE T1 | | 著者 | Doumen, J, Gonciarz, M, Zegers, I, Loris, R, Wyns, L, Steyaert, J. | | 登録日 | 1996-01-04 | | 公開日 | 1996-08-17 | | 最終更新日 | 2021-11-03 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | A catalytic function for the structurally conserved residue Phe 100 of ribonuclease T1.
Protein Sci., 5, 1996
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2QVW
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4BIR
 | | RIBONUCLEASE T1: FREE HIS92GLN MUTANT | | 分子名称: | CALCIUM ION, GUANYL-SPECIFIC RIBONUCLEASE T1 | | 著者 | Doumen, J, Steyaert, J. | | 登録日 | 1998-01-13 | | 公開日 | 1998-07-15 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Role of histidine-40 in ribonuclease T1 catalysis: three-dimensionalstructures of the partially active His40Lys mutant.
Biochemistry, 31, 1992
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2FFL
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2BIR
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5WFE
 | | Cas1-Cas2-IHF-DNA holo-complex | | 分子名称: | CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, DNA (28-MER), ... | | 著者 | Wright, A.V, Liu, J.J, Nogales, E, Doudna, J.A. | | 登録日 | 2017-07-11 | | 公開日 | 2017-08-02 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.64 Å) | | 主引用文献 | Structures of the CRISPR genome integration complex.
Science, 357, 2017
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5VVK
 | | Cas1-Cas2 bound to full-site mimic | | 分子名称: | CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, DNA (5'-D(*GP*AP*CP*CP*AP*CP*CP*AP*GP*TP*G)-3'), ... | | 著者 | Wright, A.V, Knott, G.J, Doxzen, K.D, Doudna, J.A. | | 登録日 | 2017-05-19 | | 公開日 | 2017-08-02 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structures of the CRISPR genome integration complex.
Science, 357, 2017
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5W1H
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5VVJ
 | | Cas1-Cas2 bound to half-site intermediate | | 分子名称: | CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, DNA (112-MER), ... | | 著者 | Wright, A.V, Knott, G.J, Doxzen, K.W, Doudna, J.A. | | 登録日 | 2017-05-19 | | 公開日 | 2017-08-02 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (3.89 Å) | | 主引用文献 | Structures of the CRISPR genome integration complex.
Science, 357, 2017
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5W1I
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5WLH
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6NY3
 | | CasX ternary complex with 30bp target DNA | | 分子名称: | CasX, DNA Non-target strand, DNA target strand, ... | | 著者 | Liu, J.J, Orlova, N, Nogales, E, Doudna, J.A. | | 登録日 | 2019-02-10 | | 公開日 | 2019-02-27 | | 最終更新日 | 2019-12-25 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | CasX enzymes comprise a distinct family of RNA-guided genome editors.
Nature, 566, 2019
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6NY2
 | | CasX-gRNA-DNA(45bp) state I | | 分子名称: | CasX, DNA Non-target strand, DNA target strand, ... | | 著者 | Liu, J.J, Orlova, N, Nogales, E, Doudna, J.A. | | 登録日 | 2019-02-10 | | 公開日 | 2019-02-27 | | 最終更新日 | 2019-12-25 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | CasX enzymes comprise a distinct family of RNA-guided genome editors.
Nature, 566, 2019
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4CMQ
 | | Crystal structure of Mn-bound S.pyogenes Cas9 | | 分子名称: | CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MANGANESE (II) ION, SULFATE ION | | 著者 | Jinek, M, Jiang, F, Taylor, D.W, Sternberg, S.H, Kaya, E, Ma, E, Anders, C, Hauer, M, Zhou, K, Lin, S, Kaplan, M, Iavarone, A.T, Charpentier, E, Nogales, E, Doudna, J.A. | | 登録日 | 2014-01-17 | | 公開日 | 2014-02-12 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (3.09 Å) | | 主引用文献 | Structures of Cas9 Endonucleases Reveal RNA- Mediated Conformational Activation
Science, 343, 2014
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1KH6
 | | Crystal Structure of an RNA Tertiary Domain Essential to HCV IRES-mediated Translation Initiation. | | 分子名称: | JIIIabc | | 著者 | Kieft, J.S, Zhou, K, Grech, A, Jubin, R, Doudna, J.A. | | 登録日 | 2001-11-29 | | 公開日 | 2002-04-26 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Crystal structure of an RNA tertiary domain essential to HCV IRES-mediated translation initiation.
Nat.Struct.Biol., 9, 2002
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1KXK
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9BKQ
 | | Structure of penguinpox cGAMP PDE in apo and post reaction states | | 分子名称: | 9-{3-O-[(S)-thiophosphono]-alpha-L-lyxofuranosyl}-9H-purin-6-amine, GUANINE, Penguinpox cGAMP PDE | | 著者 | Hobbs, S.J, Nomburg, J, Doudna, J.A, Kranzusch, P.J. | | 登録日 | 2024-04-29 | | 公開日 | 2024-09-04 | | 最終更新日 | 2024-09-11 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Animal and bacterial viruses share conserved mechanisms of immune evasion.
Cell, 2024
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9CIW
 | | Penguinpox cGAMP PDE H72A mutant in complex with 2'3'-cGAMP | | 分子名称: | Penguinpox cGAMP PDE, [(2~{R},3~{R},4~{R},5~{S})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl [(2~{R},3~{R},4~{S},5~{R})-2-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-5-(hydroxymethyl)-4-oxidanyl-oxolan-3-yl] hydrogen phosphate | | 著者 | Hobbs, S.J, Nomburg, J, Doudna, J.A, Kranzusch, P.J. | | 登録日 | 2024-07-05 | | 公開日 | 2024-09-04 | | 最終更新日 | 2024-09-11 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Animal and bacterial viruses share conserved mechanisms of immune evasion.
Cell, 2024
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7NTM
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6P7M
 | | Cryo-EM structure of LbCas12a-crRNA: AcrVA4 (1:2 complex) | | 分子名称: | Cas12a, MAGNESIUM ION, anti-CRISPR VA4, ... | | 著者 | Knott, G.J, Liu, J.J, Doudna, J.A. | | 登録日 | 2019-06-06 | | 公開日 | 2019-08-21 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a.
Elife, 8, 2019
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6P7N
 | | Cryo-EM structure of LbCas12a-crRNA: AcrVA4 (2:2 complex) | | 分子名称: | Cas12a, MAGNESIUM ION, anti-CRISPR VA4, ... | | 著者 | Knott, G.J, Liu, J.J, Doudna, J.A. | | 登録日 | 2019-06-06 | | 公開日 | 2019-08-21 | | 最終更新日 | 2023-08-16 | | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | | 主引用文献 | Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a.
Elife, 8, 2019
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