2XLJ
 
 | | Crystal structure of the Csy4-crRNA complex, hexagonal form | | Descriptor: | 5'-R(*CP*UP*GP*CP*CP*GP*UP*AP*UP*AP*GP*GP*CP*A*DG*C)-3', CSY4 ENDORIBONUCLEASE | | Authors: | Haurwitz, R.E, Jinek, M, Wiedenheft, B, Zhou, K, Doudna, J.A. | | Deposit date: | 2010-07-20 | | Release date: | 2010-09-22 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Sequence- and Structure-Specific RNA Processing by a Crispr Endonuclease.
Science, 329, 2010
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2XLK
 | | Crystal structure of the Csy4-crRNA complex, orthorhombic form | | Descriptor: | 5'-R(*CP*UP*GP*CP*CP*GP*UP*AP*UP*AP*GP*GP*CP*A*DG*C)-3', CSY4 ENDORIBONUCLEASE | | Authors: | Haurwitz, R.E, Jinek, M, Wiedenheft, B, Zhou, K, Doudna, J.A. | | Deposit date: | 2010-07-21 | | Release date: | 2010-09-22 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.805 Å) | | Cite: | Sequence- and Structure-Specific RNA Processing by a Crispr Endonuclease.
Science, 329, 2010
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8FYB
 | | Cryo-EM structure of Cas1:Cas2-DEDDh:half-site integration complex | | Descriptor: | Cas1, Cas2-DEDDh, DNA (17-MER), ... | | Authors: | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | | Deposit date: | 2023-01-25 | | Release date: | 2023-05-03 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Genome expansion by a CRISPR trimmer-integrase.
Nature, 618, 2023
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8FYC
 | | Cryo-EM structure of Cas1:Cas2-DEDDh:half-site integration complex linear CRISPR repeat conformation | | Descriptor: | Cas1, Cas2-DEDDh, DEDDh, ... | | Authors: | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | | Deposit date: | 2023-01-25 | | Release date: | 2023-05-03 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Genome expansion by a CRISPR trimmer-integrase.
Nature, 618, 2023
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8FYD
 | | Cryo-EM structure of Cas1:Cas2-DEDDh:half-site integration complex bent CRISPR repeat conformation | | Descriptor: | Cas1, Cas2-DEDDh, DNA (13-MER), ... | | Authors: | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | | Deposit date: | 2023-01-25 | | Release date: | 2023-05-03 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Genome expansion by a CRISPR trimmer-integrase.
Nature, 618, 2023
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6P7M
 | | Cryo-EM structure of LbCas12a-crRNA: AcrVA4 (1:2 complex) | | Descriptor: | Cas12a, MAGNESIUM ION, anti-CRISPR VA4, ... | | Authors: | Knott, G.J, Liu, J.J, Doudna, J.A. | | Deposit date: | 2019-06-06 | | Release date: | 2019-08-21 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a.
Elife, 8, 2019
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6P7N
 | | Cryo-EM structure of LbCas12a-crRNA: AcrVA4 (2:2 complex) | | Descriptor: | Cas12a, MAGNESIUM ION, anti-CRISPR VA4, ... | | Authors: | Knott, G.J, Liu, J.J, Doudna, J.A. | | Deposit date: | 2019-06-06 | | Release date: | 2019-08-21 | | Last modified: | 2023-08-16 | | Method: | ELECTRON MICROSCOPY (4.9 Å) | | Cite: | Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a.
Elife, 8, 2019
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6NY1
 | | CasX-gRNA-DNA(30bp) State II | | Descriptor: | CasX, DNA Non-target strand, DNA target strand, ... | | Authors: | Liu, J.J, Orlova, N, Nogales, E, Doudna, J.A. | | Deposit date: | 2019-02-10 | | Release date: | 2019-02-27 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | CasX enzymes comprise a distinct family of RNA-guided genome editors.
Nature, 566, 2019
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8DC2
 | | Cryo-EM structure of CasLambda (Cas12l) bound to crRNA and DNA | | Descriptor: | CasLambda, DNA NTS, DNA TS, ... | | Authors: | Al-Shayeb, B, Skopintsev, P, Soczek, K, Doudna, J. | | Deposit date: | 2022-06-15 | | Release date: | 2022-12-14 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (2.99 Å) | | Cite: | Diverse virus-encoded CRISPR-Cas systems include streamlined genome editors.
Cell, 185, 2022
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8VXY
 | | Structure of HamA(E138A,K140A)B-plasmid DNA complex from the Escherichia coli Hachiman defense system | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, HamA, HamB, ... | | Authors: | Tuck, O.T, Hu, J.J, Doudna, J.A. | | Deposit date: | 2024-02-06 | | Release date: | 2024-03-13 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.19 Å) | | Cite: | Hachiman is a genome integrity sensor.
Biorxiv, 2024
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8FYA
 | | Cryo-EM structure of Cas1:Cas2-DEDDh:PAM-containing prespacer complex | | Descriptor: | Cas1, Cas2-DEDDh, DNA (28-MER), ... | | Authors: | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | | Deposit date: | 2023-01-25 | | Release date: | 2023-05-03 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (2.91 Å) | | Cite: | Genome expansion by a CRISPR trimmer-integrase.
Nature, 618, 2023
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8FY9
 | | Cryo-EM structure of Cas1:Cas2-DEDDh:PAM-deficient prespacer complex | | Descriptor: | Cas1, Cas2-DEDDh, DNA (28-MER) | | Authors: | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | | Deposit date: | 2023-01-25 | | Release date: | 2023-05-03 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Genome expansion by a CRISPR trimmer-integrase.
Nature, 618, 2023
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8VXA
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8VXC
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8VX9
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5WFE
 | | Cas1-Cas2-IHF-DNA holo-complex | | Descriptor: | CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, DNA (28-MER), ... | | Authors: | Wright, A.V, Liu, J.J, Nogales, E, Doudna, J.A. | | Deposit date: | 2017-07-11 | | Release date: | 2017-08-02 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.64 Å) | | Cite: | Structures of the CRISPR genome integration complex.
Science, 357, 2017
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6NY2
 | | CasX-gRNA-DNA(45bp) state I | | Descriptor: | CasX, DNA Non-target strand, DNA target strand, ... | | Authors: | Liu, J.J, Orlova, N, Nogales, E, Doudna, J.A. | | Deposit date: | 2019-02-10 | | Release date: | 2019-02-27 | | Last modified: | 2019-12-25 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | CasX enzymes comprise a distinct family of RNA-guided genome editors.
Nature, 566, 2019
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6NY3
 | | CasX ternary complex with 30bp target DNA | | Descriptor: | CasX, DNA Non-target strand, DNA target strand, ... | | Authors: | Liu, J.J, Orlova, N, Nogales, E, Doudna, J.A. | | Deposit date: | 2019-02-10 | | Release date: | 2019-02-27 | | Last modified: | 2019-12-25 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | CasX enzymes comprise a distinct family of RNA-guided genome editors.
Nature, 566, 2019
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5K4C
 | | Structure of eukaryotic translation initiation factor 3 subunit D (eIF3d) cap binding domain from Nasonia vitripennis, Crystal form 2 | | Descriptor: | Eukaryotic translation initiation factor 3 subunit D, GLYCEROL | | Authors: | Kranzusch, P.J, Lee, A.S.Y, Doudna, J.A, Cate, J.H.D. | | Deposit date: | 2016-05-20 | | Release date: | 2016-07-27 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.698 Å) | | Cite: | eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation.
Nature, 536, 2016
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5VVK
 | | Cas1-Cas2 bound to full-site mimic | | Descriptor: | CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, DNA (5'-D(*GP*AP*CP*CP*AP*CP*CP*AP*GP*TP*G)-3'), ... | | Authors: | Wright, A.V, Knott, G.J, Doxzen, K.D, Doudna, J.A. | | Deposit date: | 2017-05-19 | | Release date: | 2017-08-02 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structures of the CRISPR genome integration complex.
Science, 357, 2017
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5HOH
 | | RIBONUCLEASE T1 (ASN9ALA/THR93ALA DOUBLEMUTANT) COMPLEXED WITH 2'GMP | | Descriptor: | CALCIUM ION, GUANOSINE-2'-MONOPHOSPHATE, PROTEIN (RIBONUCLEASE T1) | | Authors: | Langhorst, U, Loris, R, Denisov, V.P, Doumen, J, Roose, P, Maes, D, Halle, B, Steyaert, J. | | Deposit date: | 1998-09-14 | | Release date: | 1998-09-23 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Dissection of the structural and functional role of a conserved hydration site in RNase T1.
Protein Sci., 8, 1999
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6MCC
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6MCB
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7THB
 | | Crystal structure of an RNA-5'/DNA-3' strand exchange junction | | Descriptor: | DNA (5'-D(*GP*AP*TP*GP*CP*TP*C)-3'), DNA (5'-D(*GP*TP*AP*AP*GP*CP*AP*GP*CP*AP*TP*C)-3'), RNA (5'-R(*AP*GP*CP*UP*UP*AP*C)-3') | | Authors: | Cofsky, J.C, Knott, G.J, Gee, C.L, Doudna, J.A. | | Deposit date: | 2022-01-10 | | Release date: | 2022-04-27 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.64 Å) | | Cite: | Crystal structure of an RNA/DNA strand exchange junction.
Plos One, 17, 2022
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7S37
 | | Cas9:sgRNA (S. pyogenes) in the open-protein conformation | | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, Single-guide RNA | | Authors: | Cofsky, J.C, Soczek, K.M, Knott, G.J, Nogales, E, Doudna, J.A. | | Deposit date: | 2021-09-04 | | Release date: | 2022-04-20 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | CRISPR-Cas9 bends and twists DNA to read its sequence.
Nat.Struct.Mol.Biol., 29, 2022
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