8FD7
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![BU of 8fd7 by Molmil](/molmil-images/mine/8fd7) | Structure of the human L-type voltage-gated calcium channel Cav1.2 complexed with gabapentin | Descriptor: | (2R)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(dodecanoyloxy)propyl heptadecanoate, (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(dodecanoyloxy)propyl dodecanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Chen, Z, Mondal, A, Minor, D.L. | Deposit date: | 2022-12-02 | Release date: | 2023-03-22 | Last modified: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis for Ca V alpha 2 delta :gabapentin binding. Nat.Struct.Mol.Biol., 30, 2023
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6BGJ
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![BU of 6bgj by Molmil](/molmil-images/mine/6bgj) | Cryo-EM structure of the TMEM16A calcium-activated chloride channel in LMNG | Descriptor: | Anoctamin-1, CALCIUM ION | Authors: | Dang, S, Feng, S, Tien, J, Peters, C.J, Bulkley, D, Lolicato, M, Zhao, J, Zuberbuhler, K, Ye, W, Qi, L, Chen, T, Craik, C.S, Jan, Y.N, Minor Jr, D.L, Cheng, Y, Jan, L.Y. | Deposit date: | 2017-10-28 | Release date: | 2017-12-27 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Cryo-EM structures of the TMEM16A calcium-activated chloride channel. Nature, 552, 2017
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6BGI
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![BU of 6bgi by Molmil](/molmil-images/mine/6bgi) | Cryo-EM structure of the TMEM16A calcium-activated chloride channel in nanodisc | Descriptor: | Anoctamin-1, CALCIUM ION | Authors: | Dang, S, Feng, S, Tien, J, Peters, C.J, Bulkley, D, Lolicato, M, Zhao, J, Zuberbuhler, K, Ye, W, Qi, J, Chen, T, Craik, C.S, Jan, Y.N, Minor Jr, D.L, Cheng, Y, Jan, L.Y. | Deposit date: | 2017-10-28 | Release date: | 2017-12-27 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Cryo-EM structures of the TMEM16A calcium-activated chloride channel. Nature, 552, 2017
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8TAR
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![BU of 8tar by Molmil](/molmil-images/mine/8tar) | APC/C-CDH1-UBE2C-Ubiquitin-CyclinB-NTD | Descriptor: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | Authors: | Bodrug, T, Welsh, K.A, Bolhuis, D.L, Paulakonis, E, Martinez-Chacin, R.C, Liu, B, Pinkin, N, Bonacci, T, Cui, L, Xu, P, Roscow, O, Amann, S.J, Grishkovskaya, I, Emanuele, M.J, Harrison, J.S, Steimel, J.P, Hahn, K.M, Zhang, W, Zhong, E, Haselbach, D, Brown, N.G. | Deposit date: | 2023-06-27 | Release date: | 2023-09-27 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C). Nat.Struct.Mol.Biol., 30, 2023
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8TAU
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![BU of 8tau by Molmil](/molmil-images/mine/8tau) | APC/C-CDH1-UBE2C-UBE2S-Ubiquitin-CyclinB | Descriptor: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | Authors: | Bodrug, T, Welsh, K.A, Bolhuis, D.L, Paulakonis, E, Martinez-Chacin, R.C, Liu, B, Pinkin, N, Bonacci, T, Cui, L, Xu, P, Roscow, O, Amann, S.J, Grishkovskaya, I, Emanuele, M.J, Harrison, J.S, Steimel, J.P, Hahn, K.M, Zhang, W, Zhong, E, Haselbach, D, Brown, N.G. | Deposit date: | 2023-06-27 | Release date: | 2023-09-27 | Last modified: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C). Nat.Struct.Mol.Biol., 30, 2023
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3EU0
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![BU of 3eu0 by Molmil](/molmil-images/mine/3eu0) | Crystal structure of the S-nitrosylated Cys215 of PTP1B | Descriptor: | Tyrosine-protein phosphatase non-receptor type 1 | Authors: | Chu, H.M, Wang, A.H.J, Chen, Y.Y, Pan, K.T, Wang, D.L, Khoo, K.H, Meng, T.C. | Deposit date: | 2008-10-09 | Release date: | 2008-11-11 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Cysteine S-Nitrosylation Protects Protein-tyrosine Phosphatase 1B against Oxidation-induced Permanent Inactivation J.Biol.Chem., 283, 2008
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8T41
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![BU of 8t41 by Molmil](/molmil-images/mine/8t41) | |
3FLB
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![BU of 3flb by Molmil](/molmil-images/mine/3flb) | |
3DFV
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![BU of 3dfv by Molmil](/molmil-images/mine/3dfv) | Adjacent GATA DNA binding | Descriptor: | DNA (5'-D(*DAP*DAP*DGP*DCP*DAP*DGP*DAP*DTP*DAP*DAP*DGP*DTP*DCP*DTP*DTP*DAP*DTP*DCP*DAP*DG)-3'), DNA (5'-D(*DTP*DTP*DCP*DTP*DGP*DAP*DTP*DAP*DAP*DGP*DAP*DCP*DTP*DTP*DAP*DTP*DCP*DTP*DGP*DC)-3'), Trans-acting T-cell-specific transcription factor GATA-3, ... | Authors: | Bates, D.L, Kim, G.K, Guo, L, Chen, L. | Deposit date: | 2008-06-12 | Release date: | 2008-07-29 | Last modified: | 2017-10-25 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Crystal structures of multiple GATA zinc fingers bound to DNA reveal new insights into DNA recognition and self-association by GATA. J.Mol.Biol., 381, 2008
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8WT5
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![BU of 8wt5 by Molmil](/molmil-images/mine/8wt5) | |
3D03
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![BU of 3d03 by Molmil](/molmil-images/mine/3d03) | 1.9A structure of Glycerophoshphodiesterase (GpdQ) from Enterobacter aerogenes | Descriptor: | COBALT (II) ION, Phosphohydrolase | Authors: | Hadler, K.S, Tanifum, E, Yip, S.H.-C, Miti, N, Guddat, L.W, Jackson, C.J, Gahan, L.R, Carr, P.D, Nguyen, K, Ollis, D.L, Hengge, A.C, Larrabee, J.A, Schenk, G. | Deposit date: | 2008-04-30 | Release date: | 2008-10-14 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Substrate-promoted formation of a catalytically competent binuclear center and regulation of reactivity in a glycerophosphodiesterase from Enterobacter aerogenes. J.Am.Chem.Soc., 130, 2008
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8A1R
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![BU of 8a1r by Molmil](/molmil-images/mine/8a1r) | cryo-EM structure of thioredoxin glutathione reductase in complex with a non-competitive inhibitor | Descriptor: | (2~{R},3~{R},4~{S},5~{R})-2-[3-[[[(1~{R},2~{R},3~{R},5~{S})-2,6,6-trimethyl-3-bicyclo[3.1.1]heptanyl]amino]methyl]indol-1-yl]oxane-3,4,5-triol, FLAVIN-ADENINE DINUCLEOTIDE, Thioredoxin glutathione reductase | Authors: | Ardini, M, Angelucci, F, Fata, F, Gabriele, F, Effantin, G, Ling, W, Williams, D.L, Petukhova, V.Z, Petukhov, P.A. | Deposit date: | 2022-06-01 | Release date: | 2023-06-14 | Last modified: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Non-covalent inhibitors of thioredoxin glutathione reductase with schistosomicidal activity in vivo. Nat Commun, 14, 2023
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3DVE
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![BU of 3dve by Molmil](/molmil-images/mine/3dve) | Crystal Structure of Ca2+/CaM-CaV2.2 IQ domain complex | Descriptor: | CALCIUM ION, Calmodulin, NICKEL (II) ION, ... | Authors: | Kim, E.Y, Rumpf, C.H, Fujiwara, Y, Cooley, E.S, Van Petegem, F, Minor, D.L. | Deposit date: | 2008-07-18 | Release date: | 2008-11-04 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structures of Ca(V)2 Ca(2+)/CaM-IQ Domain Complexes Reveal Binding Modes that Underlie Calcium-Dependent Inactivation and Facilitation. Structure, 16, 2008
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3DVM
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![BU of 3dvm by Molmil](/molmil-images/mine/3dvm) | Crystal Structure of Ca2+/CaM-CaV2.1 IQ domain complex | Descriptor: | CALCIUM ION, Calmodulin, Voltage-dependent P/Q-type calcium channel subunit alpha-1A | Authors: | Kim, E.Y, Rumpf, C.H, Fujiwara, Y, Cooley, E.S, Van Petegem, F, Minor, D.L. | Deposit date: | 2008-07-18 | Release date: | 2008-11-04 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structures of Ca(V)2 Ca(2+)/CaM-IQ Domain Complexes Reveal Binding Modes that Underlie Calcium-Dependent Inactivation and Facilitation. Structure, 16, 2008
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3DVK
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![BU of 3dvk by Molmil](/molmil-images/mine/3dvk) | Crystal Structure of Ca2+/CaM-CaV2.3 IQ domain complex | Descriptor: | CALCIUM ION, Calmodulin, Voltage-dependent R-type calcium channel subunit alpha-1E | Authors: | Kim, E.Y, Rumpf, C.H, Fujiwara, Y, Cooley, E.S, Van Petegem, F, Minor, D.L. | Deposit date: | 2008-07-18 | Release date: | 2008-11-04 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structures of Ca(V)2 Ca(2+)/CaM-IQ Domain Complexes Reveal Binding Modes that Underlie Calcium-Dependent Inactivation and Facilitation. Structure, 16, 2008
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3DM0
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![BU of 3dm0 by Molmil](/molmil-images/mine/3dm0) | Maltose Binding Protein fusion with RACK1 from A. thaliana | Descriptor: | 1,2-ETHANEDIOL, Maltose-binding periplasmic protein fused with RACK1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Ullah, H, Scappini, E.L, Moon, A.F, Williams, L.V, Armstrong, D.L, Pedersen, L.C. | Deposit date: | 2008-06-30 | Release date: | 2008-09-09 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of a signal transduction regulator, RACK1, from Arabidopsis thaliana. Protein Sci., 17, 2008
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8VSX
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![BU of 8vsx by Molmil](/molmil-images/mine/8vsx) | NMR Structure of GCAP5 R22A | Descriptor: | Guanylyl cyclase-activating protein 1 | Authors: | Cudia, D.L, Ames, J.B. | Deposit date: | 2024-01-24 | Release date: | 2024-05-08 | Last modified: | 2024-06-05 | Method: | SOLUTION NMR | Cite: | NMR Structure of Retinal Guanylate Cyclase Activating Protein 5 (GCAP5) with R22A Mutation That Abolishes Dimerization and Enhances Cyclase Activation. Biochemistry, 63, 2024
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3E12
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![BU of 3e12 by Molmil](/molmil-images/mine/3e12) | Cu2+ substituted Aquifex aeolicus KDO8PS in complex with KDO8P | Descriptor: | 2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-8-O-phosphono-D-manno-oct-2-ulosonic acid, ACETATE ION, ... | Authors: | Gatti, D.L. | Deposit date: | 2008-08-01 | Release date: | 2009-05-12 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Electronic structure of the metal center in the Cd(2+), Zn(2+), and Cu(2+) substituted forms of KDO8P synthase: implications for catalysis. Biochemistry, 48, 2009
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8AQM
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![BU of 8aqm by Molmil](/molmil-images/mine/8aqm) | Crystal structure of PPARG and NCOR2 with an inverse agonist (compound 6a) | Descriptor: | 2-chloranyl-~{N}-[2-(3-methylphenyl)-1,3-benzoxazol-5-yl]-5-nitro-benzamide, Nuclear receptor corepressor 2, Peroxisome proliferator-activated receptor gamma | Authors: | Friberg, A, Orsi, D.L, Pook, E, Braeuer, N, Lemke, C.T, Stellfeld, T, Puetter, V, Goldstein, J. | Deposit date: | 2022-08-12 | Release date: | 2022-11-09 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Discovery and Structure-Based Design of Potent Covalent PPAR gamma Inverse-Agonists BAY-4931 and BAY-0069 . J.Med.Chem., 65, 2022
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8AQN
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![BU of 8aqn by Molmil](/molmil-images/mine/8aqn) | Crystal structure of PPARG and NCOR2 with BAY-4931, an inverse agonist (compound 6c) | Descriptor: | 2-chloranyl-~{N}-[2-(4-ethylphenyl)-1,3-benzoxazol-5-yl]-5-nitro-benzamide, CALCIUM ION, GLYCEROL, ... | Authors: | Friberg, A, Orsi, D.L, Pook, E, Braeuer, N, Lemke, C.T, Stellfeld, T, Puetter, V, Goldstein, J. | Deposit date: | 2022-08-12 | Release date: | 2022-11-09 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Discovery and Structure-Based Design of Potent Covalent PPAR gamma Inverse-Agonists BAY-4931 and BAY-0069 . J.Med.Chem., 65, 2022
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8UEC
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![BU of 8uec by Molmil](/molmil-images/mine/8uec) | |
3E0I
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![BU of 3e0i by Molmil](/molmil-images/mine/3e0i) | Cu2+ substituted Aquifex aeolicus KDO8PS in complex with PEP | Descriptor: | 2-dehydro-3-deoxyphosphooctonate aldolase, COPPER (II) ION, PHOSPHATE ION, ... | Authors: | Gatti, D.L. | Deposit date: | 2008-07-31 | Release date: | 2009-05-12 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.703 Å) | Cite: | Electronic structure of the metal center in the Cd(2+), Zn(2+), and Cu(2+) substituted forms of KDO8P synthase: implications for catalysis. Biochemistry, 48, 2009
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8UF6
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![BU of 8uf6 by Molmil](/molmil-images/mine/8uf6) | |
3FLA
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![BU of 3fla by Molmil](/molmil-images/mine/3fla) | |
8UE2
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![BU of 8ue2 by Molmil](/molmil-images/mine/8ue2) | |