6QH7
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![BU of 6qh7 by Molmil](/molmil-images/mine/6qh7) | AP2 clathrin adaptor mu2T156-phosphorylated core with two cargo peptides in open+ conformation | 分子名称: | ADAPTOR-RELATED PROTEIN COMPLEX 2, MU 2 SUBUNIT, C-TERMINAL DOMAIN, ... | 著者 | Wrobel, A.G, Owen, D.J, McCoy, A.J, Evans, P.R. | 登録日 | 2019-01-15 | 公開日 | 2019-09-04 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Temporal Ordering in Endocytic Clathrin-Coated Vesicle Formation via AP2 Phosphorylation. Dev.Cell, 50, 2019
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1QTW
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![BU of 1qtw by Molmil](/molmil-images/mine/1qtw) | HIGH-RESOLUTION CRYSTAL STRUCTURE OF THE ESCHERICHIA COLI DNA REPAIR ENZYME ENDONUCLEASE IV | 分子名称: | ENDONUCLEASE IV, ZINC ION | 著者 | Hosfield, D.J, Guan, Y, Haas, B.J, Cunningham, R.P, Tainer, J.A. | 登録日 | 1999-06-29 | 公開日 | 1999-08-31 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.02 Å) | 主引用文献 | Structure of the DNA repair enzyme endonuclease IV and its DNA complex: double-nucleotide flipping at abasic sites and three-metal-ion catalysis. Cell(Cambridge,Mass.), 98, 1999
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7U7H
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![BU of 7u7h by Molmil](/molmil-images/mine/7u7h) | Cysteate acyl-ACP transferase from Alistipes finegoldii | 分子名称: | 7-keto-8-aminopelargonate synthetase-like enzyme, PYRIDOXAL-5'-PHOSPHATE | 著者 | Radka, C.D, Miller, D.J, Frank, M.W, Rock, C.O. | 登録日 | 2022-03-07 | 公開日 | 2023-01-18 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Biochemical characterization of the first step in sulfonolipid biosynthesis in Alistipes finegoldii. J.Biol.Chem., 298, 2022
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1QWO
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![BU of 1qwo by Molmil](/molmil-images/mine/1qwo) | Crystal structure of a phosphorylated phytase from Aspergillus fumigatus, revealing the structural basis for its heat resilience and catalytic pathway | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, phytase | 著者 | Xiang, T, Liu, Q, Deacon, A.M, Koshy, M, Kriksunov, I.A, Lei, X.G, Hao, Q, Thiel, D.J. | 登録日 | 2003-09-03 | 公開日 | 2004-06-01 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Crystal Structure of a Heat-resilient Phytase from Aspergillus fumigatus, Carrying a Phosphorylated Histidine J.Mol.Biol., 339, 2004
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4WNN
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![BU of 4wnn by Molmil](/molmil-images/mine/4wnn) | SPT16-H2A-H2B FACT HISTONE Complex | 分子名称: | Histone H2A.1, Histone H2B.1, PHOSPHATE ION, ... | 著者 | Kemble, D.J, Hill, C.P, Whitby, F.G, Formosa, T, McCullough, L.L. | 登録日 | 2014-10-13 | 公開日 | 2015-10-21 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | FACT Disrupts Nucleosome Structure by Binding H2A-H2B with Conserved Peptide Motifs. Mol.Cell, 60, 2015
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4DK8
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![BU of 4dk8 by Molmil](/molmil-images/mine/4dk8) | Crystal structure of LXR ligand binding domain in complex with partial agonist 5 | 分子名称: | ACETATE ION, CALCIUM ION, N-methyl-N-(4-{(1S)-2,2,2-trifluoro-1-hydroxy-1-[1-(2-methoxyethyl)-1H-pyrrol-2-yl]ethyl}phenyl)benzenesulfonamide, ... | 著者 | Piper, D.E, Kopecky, D.J, Xu, H. | 登録日 | 2012-02-03 | 公開日 | 2012-03-21 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Discovery of a new binding mode for a series of liver X receptor agonists. Bioorg.Med.Chem.Lett., 22, 2012
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6QLM
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![BU of 6qlm by Molmil](/molmil-images/mine/6qlm) | Cathepsin-K in complex with MIV-701 | 分子名称: | (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, Cathepsin K, GLYCEROL, ... | 著者 | Derbyshire, D.J. | 登録日 | 2019-02-01 | 公開日 | 2020-02-19 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Successful development of 3-oxohexahydrofuropyrrole amino acid amides as inhibitors of Cathepsin-K. To Be Published
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6QM0
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![BU of 6qm0 by Molmil](/molmil-images/mine/6qm0) | Cathepsin-K in complex with amino-oxaazabicyclo[3.3.0]octanyl containing inhibitor | 分子名称: | (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, Cathepsin K, ~{N}-[(2~{S})-1-[(3~{R},3~{a}~{R},6~{R},6~{a}~{R})-6-azanyl-3-oxidanyl-2,3,3~{a},5,6,6~{a}-hexahydrofuro[3,2-b]pyrrol-4-yl]-4-methyl-1-oxidanylidene-pentan-2-yl]-3-fluoranyl-4-[2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-yl]benzamide | 著者 | Derbyshire, D.J. | 登録日 | 2019-02-01 | 公開日 | 2020-02-19 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Successful development of 3-oxohexahydrofuropyrrole amino acid amides as inhibitors of Cathepsin-K. To Be Published
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4DSN
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![BU of 4dsn by Molmil](/molmil-images/mine/4dsn) | Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity | 分子名称: | 1,2-ETHANEDIOL, GTPase KRas, isoform 2B, ... | 著者 | Oh, A, Maurer, T, Garrenton, L.S, Pitts, K, Anderson, D.J, Skelton, N.J, Fauber, B.P, Pan, B, Malek, S, Stokoe, D, Ludlam, M, Bowman, K.K, Wu, J, Giannetti, A.M, Starovasnik, M.A, Mellman, I, Jackson, P.K, Ruldolph, J, Fang, G, Wang, W. | 登録日 | 2012-02-19 | 公開日 | 2012-04-25 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity. Proc.Natl.Acad.Sci.USA, 109, 2012
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4DB2
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![BU of 4db2 by Molmil](/molmil-images/mine/4db2) | Mss116p DEAD-box helicase domain 2 bound to an RNA duplex | 分子名称: | 5'-R(*GP*GP*GP*CP*GP*GP*GP*CP*CP*CP*GP*CP*CP*C)-3', ATP-dependent RNA helicase MSS116, mitochondrial | 著者 | Mallam, A.L, Del Campo, M, Gilman, B.D, Sidote, D.J, Lambowitz, A. | 登録日 | 2012-01-13 | 公開日 | 2012-08-29 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3.157 Å) | 主引用文献 | Structural basis for RNA-duplex recognition and unwinding by the DEAD-box helicase Mss116p. Nature, 490, 2012
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4DVE
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![BU of 4dve by Molmil](/molmil-images/mine/4dve) | Crystal structure at 2.1 A of the S-component for biotin from an ECF-type ABC transporter | 分子名称: | BIOTIN, Biotin transporter BioY, nonyl beta-D-glucopyranoside | 著者 | Berntsson, R.P.-A, ter Beek, J, Majsnerowska, M, Duurkens, R, Puri, P, Poolman, B, Slotboom, D.J. | 登録日 | 2012-02-23 | 公開日 | 2012-08-29 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Structural divergence of paralogous S components from ECF-type ABC transporters. Proc.Natl.Acad.Sci.USA, 109, 2012
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1QXD
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![BU of 1qxd by Molmil](/molmil-images/mine/1qxd) | Structural Basis for the Potent Antisickling Effect of a Novel Class of 5-Membered Heterocyclic Aldehydic Compounds | 分子名称: | FURFURAL, Hemoglobin alpha chain, Hemoglobin beta chain, ... | 著者 | Safo, M.K, Abdulmalik, O, Danso-Danquah, R, Nokuri, S, Joshi, G.S, Musayev, F.N, Asakura, T, Abraham, D.J. | 登録日 | 2003-09-05 | 公開日 | 2003-09-16 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Structural basis for the potent antisickling effect of a novel class of five-membered heterocyclic aldehydic compounds J.Med.Chem., 47, 2004
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1R12
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![BU of 1r12 by Molmil](/molmil-images/mine/1r12) | Native Aplysia ADP ribosyl cyclase | 分子名称: | ADP-ribosyl cyclase | 著者 | Love, M.L, Szebenyi, D.M.E, Kriksunov, I.A, Thiel, D.J, Munshi, C, Graeff, R, Lee, H.C, Hao, Q. | 登録日 | 2003-09-23 | 公開日 | 2004-03-09 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | ADP-ribosyl cyclase; crystal structures reveal a covalent intermediate. Structure, 12, 2004
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6QLX
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![BU of 6qlx by Molmil](/molmil-images/mine/6qlx) | Cathepsin-K in complex with fluoro-oxa-azabicyclo[3.3.0]octanyl containing inhibitor | 分子名称: | Cathepsin K, ~{N}-[(2~{S})-1-[(3~{R},3~{a}~{R},6~{S},6~{a}~{S})-6-fluoranyl-3-oxidanyl-2,3,3~{a},5,6,6~{a}-hexahydrofuro[3,2-b]pyrrol-4-yl]-4-methyl-1-oxidanylidene-pentan-2-yl]-4-thiophen-2-yl-benzamide | 著者 | Derbyshire, D.J. | 登録日 | 2019-02-01 | 公開日 | 2020-02-19 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Successful development of 3-oxohexahydrofuropyrrole amino acid amides as inhibitors of Cathepsin-K. To Be Published
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1QXE
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![BU of 1qxe by Molmil](/molmil-images/mine/1qxe) | Structural Basis for the Potent Antisickling Effect of a Novel Class of 5-Membered Heterocyclic Aldehydic Compounds | 分子名称: | 5-HYDROXYMETHYL-FURFURAL, Hemoglobin alpha chain, Hemoglobin beta chain, ... | 著者 | Safo, M.K, Abdulmalik, O, Danso-Danquah, R, Nokuri, S, Joshi, G.S, Musayev, F.N, Asakura, T, Abraham, D.J. | 登録日 | 2003-09-05 | 公開日 | 2003-09-16 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structural basis for the potent antisickling effect of a novel class of five-membered heterocyclic aldehydic compounds J.Med.Chem., 47, 2004
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1YKQ
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![BU of 1ykq by Molmil](/molmil-images/mine/1ykq) | Crystal structure of Diels-Alder ribozyme | 分子名称: | CADMIUM ION, Diels-Alder ribozyme, MAGNESIUM ION | 著者 | Serganov, A, Keiper, S, Malinina, L, Tereshko, V, Skripkin, E, Hobartner, C, Polonskaia, A, Phan, A.T, Wombacher, R, Micura, R, Dauter, Z, Jaschke, A, Patel, D.J. | 登録日 | 2005-01-18 | 公開日 | 2005-02-22 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Structural basis for Diels-Alder ribozyme-catalyzed carbon-carbon bond formation. Nat.Struct.Mol.Biol., 12, 2005
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1R0S
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![BU of 1r0s by Molmil](/molmil-images/mine/1r0s) | Crystal structure of ADP-ribosyl cyclase Glu179Ala mutant | 分子名称: | ADP-ribosyl cyclase | 著者 | Love, M.L, Szebenyi, D.M.E, Kriksunov, I.A, Thiel, D.J, Munshi, C, Graeff, R, Lee, H.C, Hao, Q. | 登録日 | 2003-09-22 | 公開日 | 2004-03-09 | 最終更新日 | 2021-10-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | ADP-ribosyl cyclase; crystal structures reveal a covalent intermediate. Structure, 12, 2004
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1OIY
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![BU of 1oiy by Molmil](/molmil-images/mine/1oiy) | Structure of human Thr160-phospho CDK2/cyclin A complexed with a 6-cyclohexylmethyloxy-2-anilino-purine inhibitor | 分子名称: | 4-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)--BENZAMIDE, CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, ... | 著者 | Pratt, D.J, Endicott, J.A, Noble, M.E.M. | 登録日 | 2003-06-26 | 公開日 | 2004-07-13 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | N2-Substituted O6-Cyclohexylmethylguanine Derivatives: Potent Inhibitors of Cyclin-Dependent Kinases 1 and 2 J.Med.Chem., 47, 2004
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1YKV
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![BU of 1ykv by Molmil](/molmil-images/mine/1ykv) | Crystal structure of the Diels-Alder ribozyme complexed with the product of the reaction between N-pentylmaleimide and covalently attached 9-hydroxymethylanthracene | 分子名称: | (3AS,9AS)-2-PENTYL-4-HYDROXYMETHYL-3A,4,9,9A-TETRAHYDRO-4,9[1',2']-BENZENO-1H-BENZ[F]ISOINDOLE-1,3(2H)-DIONE, Diels-Alder ribozyme, MAGNESIUM ION | 著者 | Serganov, A, Keiper, S, Malinina, L, Tereshko, V, Skripkin, E, Hobartner, C, Polonskaia, A, Phan, A.T, Wombacher, R, Micura, R, Dauter, Z, Jaschke, A, Patel, D.J. | 登録日 | 2005-01-18 | 公開日 | 2005-02-22 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Structural basis for Diels-Alder ribozyme-catalyzed carbon-carbon bond formation. Nat.Struct.Mol.Biol., 12, 2005
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1OI9
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![BU of 1oi9 by Molmil](/molmil-images/mine/1oi9) | Structure of human Thr160-phospho CDK2/cyclin A complexed with a 6-cyclohexylmethyloxy-2-anilino-purine inhibitor | 分子名称: | 6-CYCLOHEXYLMETHYLOXY-2-(4'-HYDROXYANILINO)PURINE, CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, ... | 著者 | Pratt, D.J, Endicott, J.A, Noble, M.E.M. | 登録日 | 2003-06-10 | 公開日 | 2004-07-13 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | N2-Substituted O6-Cyclohexylmethylguanine Derivatives: Potent Inhibitors of Cyclin-Dependent Kinases 1 and 2 J.Med.Chem., 47, 2004
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1YLS
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![BU of 1yls by Molmil](/molmil-images/mine/1yls) | Crystal structure of selenium-modified Diels-Alder ribozyme complexed with the product of the reaction between N-pentylmaleimide and covalently attached 9-hydroxymethylanthracene | 分子名称: | (3AS,9AS)-2-PENTYL-4-HYDROXYMETHYL-3A,4,9,9A-TETRAHYDRO-4,9[1',2']-BENZENO-1H-BENZ[F]ISOINDOLE-1,3(2H)-DIONE, MAGNESIUM ION, RNA Diels-Alder ribozyme | 著者 | Serganov, A, Keiper, S, Malinina, L, Tereshko, V, Skripkin, E, Hobartner, C, Polonskaia, A, Phan, A.T, Wombacher, R, Micura, R, Dauter, Z, Jaschke, A, Patel, D.J. | 登録日 | 2005-01-19 | 公開日 | 2005-02-22 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural basis for Diels-Alder ribozyme-catalyzed carbon-carbon bond formation. Nat.Struct.Mol.Biol., 12, 2005
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1YN3
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![BU of 1yn3 by Molmil](/molmil-images/mine/1yn3) | Crystal Structures of EAP Domains from Staphylococcus aureus Reveal an Unexpected Homology to Bacterial Superantigens | 分子名称: | truncated cell surface protein map-w | 著者 | Geisbrecht, B.V, Hamaoka, B.Y, Perman, B, Zemla, A, Leahy, D.J. | 登録日 | 2005-01-23 | 公開日 | 2005-03-01 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | The Crystal Structures of EAP Domains from Staphylococcus aureus Reveal an Unexpected Homology to Bacterial Superantigens. J.Biol.Chem., 280, 2005
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4DHF
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![BU of 4dhf by Molmil](/molmil-images/mine/4dhf) | Structure of Aurora A mutant bound to Biogenidec cpd 15 | 分子名称: | 7-cyclopentyl-2-({1-methyl-5-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-3-yl}amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide, Aurora kinase A, MAGNESIUM ION, ... | 著者 | Silvian, L, Marcotte, D.J. | 登録日 | 2012-01-27 | 公開日 | 2012-07-18 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure-based design of 2,6,7-trisubstituted-7H-pyrrolo[2,3-d]pyrimidines as Aurora kinases inhibitors. Bioorg.Med.Chem.Lett., 22, 2012
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1OIU
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![BU of 1oiu by Molmil](/molmil-images/mine/1oiu) | Structure of human Thr160-phospho CDK2/cyclin A complexed with a 6-cyclohexylmethyloxy-2-anilino-purine inhibitor | 分子名称: | 3-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)-BENZENESULFONAMIDE, CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, ... | 著者 | Pratt, D.J, Endicott, J.A, Noble, M.E.M. | 登録日 | 2003-06-26 | 公開日 | 2004-07-13 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | N2-Substituted O6-Cyclohexylmethylguanine Derivatives: Potent Inhibitors of Cyclin-Dependent Kinases 1 and 2 J.Med.Chem., 47, 2004
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4DOW
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![BU of 4dow by Molmil](/molmil-images/mine/4dow) | |