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6QLX

Cathepsin-K in complex with fluoro-oxa-azabicyclo[3.3.0]octanyl containing inhibitor

Summary for 6QLX
Entry DOI10.2210/pdb6qlx/pdb
Related6QL8
DescriptorCathepsin K, ~{N}-[(2~{S})-1-[(3~{R},3~{a}~{R},6~{S},6~{a}~{S})-6-fluoranyl-3-oxidanyl-2,3,3~{a},5,6,6~{a}-hexahydrofuro[3,2-b]pyrrol-4-yl]-4-methyl-1-oxidanylidene-pentan-2-yl]-4-thiophen-2-yl-benzamide (3 entities in total)
Functional Keywordsinhibitor complex, lysosomal cysteine proteinase, hydrolase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight24127.21
Authors
Derbyshire, D.J. (deposition date: 2019-02-01, release date: 2020-02-19)
Primary citationDerbyshire, D.J.
Successful development of 3-oxohexahydrofuropyrrole amino acid amides as inhibitors of Cathepsin-K.
To Be Published,
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

217705

PDB entries from 2024-03-27

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