6QM0
Cathepsin-K in complex with amino-oxaazabicyclo[3.3.0]octanyl containing inhibitor
Summary for 6QM0
Entry DOI | 10.2210/pdb6qm0/pdb |
Related | 6QL8 |
Descriptor | Cathepsin K, (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, ~{N}-[(2~{S})-1-[(3~{R},3~{a}~{R},6~{R},6~{a}~{R})-6-azanyl-3-oxidanyl-2,3,3~{a},5,6,6~{a}-hexahydrofuro[3,2-b]pyrrol-4-yl]-4-methyl-1-oxidanylidene-pentan-2-yl]-3-fluoranyl-4-[2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-yl]benzamide, ... (4 entities in total) |
Functional Keywords | inhibitor complex, lysosomal cysteine proteinase, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 48672.87 |
Authors | |
Primary citation | Derbyshire, D.J. Successful development of 3-oxohexahydrofuropyrrole amino acid amides as inhibitors of Cathepsin-K. To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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