4DHF
Structure of Aurora A mutant bound to Biogenidec cpd 15
Summary for 4DHF
| Entry DOI | 10.2210/pdb4dhf/pdb |
| Related | 3R21 3R22 |
| Descriptor | Aurora kinase A, 7-cyclopentyl-2-({1-methyl-5-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-3-yl}amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide, PHOSPHATE ION, ... (4 entities in total) |
| Functional Keywords | ser/thr kinase mitotic kinase pyrazolopyrimidine, phosphorylation, tpx2, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm, cytoskeleton, centrosome: O14965 |
| Total number of polymer chains | 2 |
| Total formula weight | 63833.50 |
| Authors | Silvian, L.,Marcotte, D.J. (deposition date: 2012-01-27, release date: 2012-07-18, Last modification date: 2024-02-28) |
| Primary citation | Le Brazidec, J.Y.,Pasis, A.,Tam, B.,Boykin, C.,Wang, D.,Marcotte, D.J.,Claassen, G.,Chong, J.H.,Chao, J.,Fan, J.,Nguyen, K.,Silvian, L.,Ling, L.,Zhang, L.,Choi, M.,Teng, M.,Pathan, N.,Zhao, S.,Li, T.,Taveras, A. Structure-based design of 2,6,7-trisubstituted-7H-pyrrolo[2,3-d]pyrimidines as Aurora kinases inhibitors. Bioorg.Med.Chem.Lett., 22:4033-4037, 2012 Cited by PubMed: 22607669DOI: 10.1016/j.bmcl.2012.04.085 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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