4DHF
Structure of Aurora A mutant bound to Biogenidec cpd 15
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Aurora kinase A | polymer | 271 | 31346.9 | 2 | UniProt (O14965) Pfam (PF00069) In PDB | Homo sapiens (human) | Aurora 2, Aurora/IPL1-related kinase 1, ARK-1, Aurora-related kinase 1, hARK1, Breast tumor-amplified kinase, Serine/threonine-protein kinase 15, Serine/threonine-protein kinase 6, Serine/threonine-protein kinase aurora-A |
| 2 | A, B | 7-cyclopentyl-2-({1-methyl-5-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-3-yl}amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide | non-polymer | 450.5 | 2 | Chemie (0K6) | |||
| 3 | A, B | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 4 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) |
Sequence modifications
A, B: 126 - 391 (UniProt: O14965)
| PDB | External Database | Details |
|---|---|---|
| Gly 121 | - | expression tag |
| Pro 122 | - | expression tag |
| Leu 123 | - | expression tag |
| Gly 124 | - | expression tag |
| Ser 125 | - | expression tag |
| Asp 287 | Thr 287 | engineered mutation |
| Asp 288 | Thr 288 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 62693.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1139.6 | |
| All* | Total formula weight | 63833.5 |
