4DHF

Structure of Aurora A mutant bound to Biogenidec cpd 15

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000212	biological_process	meiotic spindle organization
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000278	biological_process	mitotic cell cycle
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
A	0007052	biological_process	mitotic spindle organization
A	0007098	biological_process	centrosome cycle
A	0007100	biological_process	mitotic centrosome separation
A	0051321	biological_process	meiotic cell cycle
B	0000212	biological_process	meiotic spindle organization
B	0000226	biological_process	microtubule cytoskeleton organization
B	0000278	biological_process	mitotic cell cycle
B	0004672	molecular_function	protein kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
B	0007052	biological_process	mitotic spindle organization
B	0007098	biological_process	centrosome cycle
B	0007100	biological_process	mitotic centrosome separation
B	0051321	biological_process	meiotic cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 0K6 A 401

Chain	Residue
A	ARG137
A	GLY216
A	THR217
A	LEU263
A	PO4402
B	SER342
A	LEU139
A	GLY140
A	VAL147
A	LEU210
A	GLU211
A	ALA213
A	PRO214
A	LEU215

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 A 402

Chain	Residue
A	LYS143
A	LYS162
A	ASN261
A	ASP274
A	0K6401
A	MG403

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG A 403

Chain	Residue
A	ASN261
A	PO4402

---

site_id	AC4
Number of Residues	16
Details	BINDING SITE FOR RESIDUE 0K6 B 401

Chain	Residue
A	SER342
B	ARG137
B	LEU139
B	GLY140
B	VAL147
B	ALA160
B	LYS162
B	LEU210
B	GLU211
B	ALA213
B	PRO214
B	LEU215
B	GLY216
B	THR217
B	LEU263
B	PO4402

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 B 402

Chain	Residue
B	LYS143
B	LYS162
B	ASN261
B	ASP274
B	0K6401
B	MG403

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG B 403

Chain	Residue
B	ASN261
B	ASP274
B	PO4402

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGKFGNVYlArekqskfi..........LALK

Chain	Residue	Details
A	LEU139-LYS162

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ViHrDIKpeNLLL

Chain	Residue	Details
A	VAL252-LEU264

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"14580337","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27837025","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5G1X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PKA and PAK","evidences":[{"source":"PubMed","id":"16246726","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---