8HK6
| potassium channel | 分子名称: | POTASSIUM ION, Potassium channel subfamily T member 1, ZINC ION | 著者 | Jiang, D.H, Zhang, J.T. | 登録日 | 2022-11-25 | 公開日 | 2023-08-16 | 実験手法 | ELECTRON MICROSCOPY (2.64 Å) | 主引用文献 | Structural basis of human Slo2.2 channel gating and modulation. Cell Rep, 42, 2023
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1BBC
| STRUCTURE OF RECOMBINANT HUMAN RHEUMATOID ARTHRITIC SYNOVIAL FLUID PHOSPHOLIPASE A2 AT 2.2 ANGSTROMS RESOLUTION | 分子名称: | PHOSPHOLIPASE A2 | 著者 | Wery, J.-P, Schevitz, R.W, Clawson, D.K, Bobbitt, J.L, Dow, E.R, Gamboa, G, Goodsonjunior, T, Hermann, R.B, Kramer, R.M, Mcclure, D.B, Mihelich, E.D, Putnam, J.E, Sharp, J.D, Stark, D.H, Teater, C, Warrick, M.W, Jones, N.D. | 登録日 | 1992-05-04 | 公開日 | 1993-10-31 | 最終更新日 | 2019-08-14 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure of recombinant human rheumatoid arthritic synovial fluid phospholipase A2 at 2.2 A resolution. Nature, 352, 1991
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8HKF
| ion channel | 分子名称: | POTASSIUM ION, Potassium channel subfamily T member 1, ZINC ION | 著者 | Jiang, D.H, Zhang, Z.T. | 登録日 | 2022-11-25 | 公開日 | 2023-08-16 | 実験手法 | ELECTRON MICROSCOPY (2.66 Å) | 主引用文献 | Structural basis of human Slo2.2 channel gating and modulation. Cell Rep, 42, 2023
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8H0H
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3C9V
| C7 Symmetrized Structure of Unliganded GroEL at 4.7 Angstrom Resolution from CryoEM | 分子名称: | 60 kDa chaperonin | 著者 | Ludtke, S.J, Baker, M.L, Chen, D.H, Song, J.L, Chuang, D, Chiu, W. | 登録日 | 2008-02-18 | 公開日 | 2008-09-02 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | 主引用文献 | De Novo Backbone Trace of GroEL from Single Particle Electron Cryomicroscopy. Structure, 16, 2008
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8FC7
| Cryo-EM structure of the human TRPV4 - RhoA in complex with GSK2798745 | 分子名称: | 1-({(5S,7S)-3-[5-(2-hydroxypropan-2-yl)pyrazin-2-yl]-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl}methyl)-1H-benzimidazole-6-carbonitrile, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Kwon, D.H, Lee, S.-Y, Zhang, F. | 登録日 | 2022-12-01 | 公開日 | 2023-07-12 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease. Nat Commun, 14, 2023
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8FC9
| Cryo-EM structure of the human TRPV4 - RhoA, apo condition | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Transforming protein RhoA, ... | 著者 | Kwon, D.H, Lee, S.-Y, Zhang, F. | 登録日 | 2022-12-01 | 公開日 | 2023-07-12 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.75 Å) | 主引用文献 | TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease. Nat Commun, 14, 2023
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8FC8
| Cryo-EM structure of the human TRPV4 in complex with GSK1016790A | 分子名称: | CHOLESTEROL HEMISUCCINATE, N-[(2S)-1-{4-[N-(2,4-dichlorobenzene-1-sulfonyl)-L-seryl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide, Transient receptor potential cation channel subfamily V member 4 | 著者 | Kwon, D.H, Lee, S.-Y, Zhang, F. | 登録日 | 2022-12-01 | 公開日 | 2023-07-12 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.47 Å) | 主引用文献 | TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease. Nat Commun, 14, 2023
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8FCB
| Cryo-EM structure of the human TRPV4 - RhoA in complex with GSK1016790A | 分子名称: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, CHOLESTEROL HEMISUCCINATE, N-[(2S)-1-{4-[N-(2,4-dichlorobenzene-1-sulfonyl)-L-seryl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide, ... | 著者 | Kwon, D.H, Lee, S.-Y, Zhang, F. | 登録日 | 2022-12-01 | 公開日 | 2023-07-12 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.52 Å) | 主引用文献 | TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease. Nat Commun, 14, 2023
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8FCA
| Cryo-EM structure of the human TRPV4 - RhoA in complex with 4alpha-Phorbol 12,13-didecanoate | 分子名称: | (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(decanoyloxy)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl decanoate, CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily V member 4 | 著者 | Kwon, D.H, Lee, S.-Y, Zhang, F. | 登録日 | 2022-12-01 | 公開日 | 2023-07-12 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.41 Å) | 主引用文献 | TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease. Nat Commun, 14, 2023
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8WA3
| Cryo-EM structure of peptide free and Gs-coupled GIPR | 分子名称: | Gastric inhibitory polypeptide receptor,Fusion protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1,O-antigen polymerase, ... | 著者 | Cong, Z.T, Zhao, F.H, Li, Y, Luo, G, Zhou, Q.T, Yang, D.H, Wang, M.W. | 登録日 | 2023-09-06 | 公開日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | 主引用文献 | Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G s proteins. Cell Discov, 10, 2024
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8WG8
| Cryo-EM structures of peptide free and Gs-coupled GCGR | 分子名称: | Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Cong, Z.T, Zhao, F.H, Li, Y, Luo, G, Zhou, Q.T, Yang, D.H, Wang, M.W. | 登録日 | 2023-09-20 | 公開日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (2.71 Å) | 主引用文献 | Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G s proteins. Cell Discov, 10, 2024
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8WG7
| Cryo-EM structures of peptide free and Gs-coupled GLP-1R | 分子名称: | Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Cong, Z.T, Zhao, F.H, Li, Y, Luo, G, Zhou, Q.T, Yang, D.H, Wang, M.W. | 登録日 | 2023-09-20 | 公開日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (2.54 Å) | 主引用文献 | Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G s proteins. Cell Discov, 10, 2024
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1AW7
| Q136A MUTANT OF TOXIC SHOCK SYNDROME TOXIN-1 FROM S. AUREUS | 分子名称: | TOXIC SHOCK SYNDROME TOXIN-1 | 著者 | Earhart, C.A, Mitchell, D.T, Murray, D.L, Pinheiro, D.M, Matsumura, M, Schlievert, P.M, Ohlendorf, D.H. | 登録日 | 1997-10-11 | 公開日 | 1998-10-28 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structures of five mutants of toxic shock syndrome toxin-1 with reduced biological activity. Biochemistry, 37, 1998
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3EA6
| Atomic resolution of crystal structure of SEK | 分子名称: | IODIDE ION, Staphylococcal enterotoxin K, ZINC ION | 著者 | Shi, K, Huseby, M, Schlievert, P.M, Ohlendorf, D.H, Earhart, C.A. | 登録日 | 2008-08-24 | 公開日 | 2009-06-30 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (0.92 Å) | 主引用文献 | Structural Studies of an Emerging Pyrogenic Superantigen, SEK To be Published
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6IHG
| N terminal domain of Mycobacterium avium complex Lon protease | 分子名称: | Lon protease | 著者 | Chen, X.Y, Zhang, S.J, Bi, F.K, Guo, C.Y, Yao, H.W, Lin, D.H. | 登録日 | 2018-09-29 | 公開日 | 2019-08-07 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.397 Å) | 主引用文献 | Crystal structure of the N domain of Lon protease from Mycobacterium avium complex. Protein Sci., 28, 2019
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3CAU
| D7 symmetrized structure of unliganded GroEL at 4.2 Angstrom resolution by cryoEM | 分子名称: | 60 kDa chaperonin | 著者 | Ludtke, S.J, Baker, M.L, Chen, D.H, Song, J.L, Chuang, D, Chiu, W. | 登録日 | 2008-02-20 | 公開日 | 2008-09-02 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | De Novo Backbone Trace of GroEL from Single Particle Electron Cryomicroscopy. Structure, 16, 2008
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1BYG
| KINASE DOMAIN OF HUMAN C-TERMINAL SRC KINASE (CSK) IN COMPLEX WITH INHIBITOR STAUROSPORINE | 分子名称: | PROTEIN (C-TERMINAL SRC KINASE), STAUROSPORINE | 著者 | Antson, A.A, Lamers, M.B.A.C, Scott, R.K, Williams, D.H, Hubbard, R.E. | 登録日 | 1998-10-14 | 公開日 | 1999-10-14 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structure of the protein tyrosine kinase domain of C-terminal Src kinase (CSK) in complex with staurosporine. J.Mol.Biol., 285, 1999
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1BYZ
| DESIGNED PEPTIDE ALPHA-1, P1 FORM | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, ... | 著者 | Prive, G.G, Anderson, D.H, Wesson, L, Cascio, D, Eisenberg, D. | 登録日 | 1998-10-20 | 公開日 | 1998-10-28 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (0.9 Å) | 主引用文献 | Packed protein bilayers in the 0.90 A resolution structure of a designed alpha helical bundle. Protein Sci., 8, 1999
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8I1B
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8YW3
| Cryo-EM structure of the retatrutide-bound human GLP-1R-Gs complex | 分子名称: | Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Li, W.Z, Zhou, Q.T, Cong, Z.T, Yuan, Q.N, Li, W.X, Zhao, F.H, Xu, H.E, Zhao, L.H, Yang, D.H, Wang, M.W. | 登録日 | 2024-03-29 | 公開日 | 2024-09-18 | 最終更新日 | 2024-09-25 | 実験手法 | ELECTRON MICROSCOPY (2.68 Å) | 主引用文献 | Structural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by retatrutide. Cell Discov, 10, 2024
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8YW4
| Cryo-EM structure of the retatrutide-bound human GIPR-Gs complex | 分子名称: | Gastric inhibitory polypeptide receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Li, W.Z, Zhou, Q.T, Cong, Z.T, Yuan, Q.N, Li, W.X, Zhao, F.H, Xu, H.E, Zhao, L.H, Yang, D.H, Wang, M.W. | 登録日 | 2024-03-29 | 公開日 | 2024-09-18 | 最終更新日 | 2024-09-25 | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | 主引用文献 | Structural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by retatrutide. Cell Discov, 10, 2024
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3DYM
| E. coli (lacZ) beta-galactosidase (H418E) | 分子名称: | Beta-galactosidase, DIMETHYL SULFOXIDE, MAGNESIUM ION, ... | 著者 | Juers, D.H, Huber, R.E, Matthews, B.W. | 登録日 | 2008-07-28 | 公開日 | 2008-10-28 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Direct and indirect roles of His-418 in metal binding and in the activity of beta-galactosidase (E. coli). Protein Sci., 18, 2009
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1BM4
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1BLX
| P19INK4D/CDK6 COMPLEX | 分子名称: | CALCIUM ION, CYCLIN-DEPENDENT KINASE 6, P19INK4D | 著者 | Brotherton, D.H, Dhanaraj, V, Wick, S, Brizuela, L, Domaille, P.J, Volyanik, E, Xu, X, Parisini, E, Smith, B.O, Archer, S.J, Serrano, M, Brenner, S.L, Blundell, T.L, Laue, E.D. | 登録日 | 1998-07-21 | 公開日 | 1999-06-01 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d. Nature, 395, 1998
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