8K3V
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![BU of 8k3v by Molmil](/molmil-images/mine/8k3v) | S. cerevisiae Chs1 in complex with UDP-GlcNAc | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Chitin synthase 1, MAGNESIUM ION, ... | 著者 | Bai, L, Chen, D. | 登録日 | 2023-07-17 | 公開日 | 2023-10-18 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structure, catalysis, chitin transport, and selective inhibition of chitin synthase. Nat Commun, 14, 2023
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8K3T
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![BU of 8k3t by Molmil](/molmil-images/mine/8k3t) | S. cerevisiae Chs1 in complex with UDP | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Chitin synthase 1, MAGNESIUM ION, ... | 著者 | Bai, L, Chen, D. | 登録日 | 2023-07-17 | 公開日 | 2023-10-18 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.57 Å) | 主引用文献 | Structure, catalysis, chitin transport, and selective inhibition of chitin synthase. Nat Commun, 14, 2023
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8JUE
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![BU of 8jue by Molmil](/molmil-images/mine/8jue) | Crystal structure of glutaminase C in complex with compound 11 | 分子名称: | 2-(3-phenoxyphenyl)-N-[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]ethanamide, Glutaminase kidney isoform, mitochondrial | 著者 | Wang, X, Hanyu, S, Tingting, D. | 登録日 | 2023-06-26 | 公開日 | 2023-10-11 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Targeting the Subpocket Enables the Discovery of Thiadiazole-Pyridazine Derivatives as Glutaminase C Inhibitors. Acs Med.Chem.Lett., 14, 2023
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8JUB
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![BU of 8jub by Molmil](/molmil-images/mine/8jub) | Crystal structure of glutaminase C in complex with compound 27 | 分子名称: | 3-[2-oxidanylidene-2-[[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]amino]ethyl]benzoic acid, Glutaminase kidney isoform, mitochondrial | 著者 | Wang, X, Hanyu, S, Tingting, D. | 登録日 | 2023-06-26 | 公開日 | 2023-10-11 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Targeting the Subpocket Enables the Discovery of Thiadiazole-Pyridazine Derivatives as Glutaminase C Inhibitors. Acs Med.Chem.Lett., 14, 2023
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5XK5
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![BU of 5xk5 by Molmil](/molmil-images/mine/5xk5) | Relaxed state of S65-phosphorylated ubiquitin | 分子名称: | Polyubiquitin-B | 著者 | Xu, D, Zhou, G, Qin, L.Y, Ran, M.L, Zhang, C.L, Liu, K, Liu, Z, Zhang, W.P, Tang, C. | 登録日 | 2017-05-05 | 公開日 | 2017-06-28 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | Ubiquitin S65 phosphorylation engenders a pH-sensitive conformational switch Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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8K5R
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![BU of 8k5r by Molmil](/molmil-images/mine/8k5r) | CDK9/cyclin T1 in complex with KB-0742 | 分子名称: | (1S,3S)-N3-(5-pentan-3-ylpyrazolo[1,5-a]pyrimidin-7-yl)cyclopentane-1,3-diamine, Cyclin-T1, Cyclin-dependent kinase 9 | 著者 | Zhou, M, Li, H, Gao, H, Trotter, B.W, Freeman, D. | 登録日 | 2023-07-24 | 公開日 | 2023-12-06 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3.751 Å) | 主引用文献 | Discovery of KB-0742, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of CDK9 for MYC-Dependent Cancers. J.Med.Chem., 66, 2023
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5XY3
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![BU of 5xy3 by Molmil](/molmil-images/mine/5xy3) | Large subunit of Trichomonas vaginalis ribosome | 分子名称: | 25S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | 著者 | Li, Z, Guo, Q, Zheng, L, Ji, Y, Xie, Y, Lai, D, Lun, Z, Suo, X, Gao, N. | 登録日 | 2017-07-06 | 公開日 | 2017-08-30 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Cryo-EM structures of the 80S ribosomes from human parasites Trichomonas vaginalis and Toxoplasma gondii Cell Res., 27, 2017
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5VZW
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![BU of 5vzw by Molmil](/molmil-images/mine/5vzw) | |
5W07
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![BU of 5w07 by Molmil](/molmil-images/mine/5w07) | CRYSTAL STRUCTURE OF THE INHA FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH AN12855, EBSI 4333. | 分子名称: | (~{N}~{E})-~{N}-[[2-[[2-ethylsulfonyl-1,1-bis(oxidanyl)-3,4-dihydro-2,3,1$l^{4}-benzodiazaborinin-7-yl]oxy]-5-(trifluoromethyl)phenyl]methylidene]hydroxylamine, Enoyl-[acyl-carrier-protein] reductase [NADH] | 著者 | Abendroth, J, Edwards, T.E, Lorimer, D. | 登録日 | 2017-05-30 | 公開日 | 2018-06-13 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA To Be Published
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5VRL
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![BU of 5vrl by Molmil](/molmil-images/mine/5vrl) | CRYSTAL STRUCTURE OF THE INHA FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH AN12855, EBSI 4333. | 分子名称: | (~{N}~{E})-~{N}-[[2-[[2-ethylsulfonyl-1,1-bis(oxidanyl)-3,4-dihydro-2,3,1$l^{4}-benzodiazaborinin-7-yl]oxy]-5-(trifluoromethyl)phenyl]methylidene]hydroxylamine, Enoyl-[acyl-carrier-protein] reductase [NADH] | 著者 | Abendroth, J, Edwards, T.E, Lorimer, D. | 登録日 | 2017-05-11 | 公開日 | 2018-05-16 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Discovery of a cofactor-independent inhibitor ofMycobacterium tuberculosisInhA. Life Sci Alliance, 1, 2018
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4F1U
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![BU of 4f1u by Molmil](/molmil-images/mine/4f1u) | Subatomic resolution structure of a high affinity periplasmic phosphate-binding protein (PfluDING) bound with phosphate at pH 4.5 | 分子名称: | 1,2-ETHANEDIOL, HYDROGENPHOSPHATE ION, Putative alkaline phosphatase, ... | 著者 | Liebschner, D, Elias, M, Tawfik, D.S, Moniot, S, Fournier, B, Scott, K, Jelsch, C, Guillot, B, Lecomte, C, Chabriere, E. | 登録日 | 2012-05-07 | 公開日 | 2012-05-23 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (0.98 Å) | 主引用文献 | The molecular basis of phosphate discrimination in arsenate-rich environments. Nature, 491, 2012
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4F1V
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![BU of 4f1v by Molmil](/molmil-images/mine/4f1v) | Subatomic resolution structure of a high affinity periplasmic phosphate-binding protein (PfluDING) bound with phosphate at pH 8.5 | 分子名称: | HYDROGENPHOSPHATE ION, Putative alkaline phosphatase, SULFATE ION | 著者 | Liebschner, D, Elias, M, Tawfik, D.S, Moniot, S, Fournier, B, Scott, K, Jelsch, C, Guillot, B, Lecomte, C, Chabriere, E. | 登録日 | 2012-05-07 | 公開日 | 2012-05-23 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (0.88 Å) | 主引用文献 | The molecular basis of phosphate discrimination in arsenate-rich environments. Nature, 491, 2012
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5HO9
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![BU of 5ho9 by Molmil](/molmil-images/mine/5ho9) | Structure of truncated AbnA (domains 1-3), a GH43 arabinanase from Geobacilllus stearothermophilus, in complex with arabinooctaose | 分子名称: | DI(HYDROXYETHYL)ETHER, Extracellular arabinanase, SULFATE ION, ... | 著者 | Lansky, S, Salama, R, Azoulai, D, Shwartstien, O, Shoham, Y, Shoham, G. | 登録日 | 2016-01-19 | 公開日 | 2017-02-01 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.845 Å) | 主引用文献 | Structure of truncated AbnA (domains 1-3), a GH43 arabinanase from Geobacilllus stearothermophilus, in complex with arabinooctaose To Be Published
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4GID
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![BU of 4gid by Molmil](/molmil-images/mine/4gid) | Structure of beta-secretase complexed with inhibitor | 分子名称: | Beta-secretase 1, L-PROLINAMIDE, N-[(2S)-1-({(2S,3R)-3-hydroxy-1-[(2-methylpropyl)amino]-1-oxobutan-2-yl}amino)-3-phenylpropan-2-yl]-5-[methyl(methylsulfonyl)amino]-N'-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide | 著者 | Ghosh, A, Tang, J, Venkateswara, R.K, Yadav, N, Anderson, D, Gavande, N, Huang, X, Terzyan, S. | 登録日 | 2012-08-08 | 公開日 | 2012-10-10 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure-based design of highly selective beta-secretase inhibitors: synthesis, biological evaluation, and protein-ligand X-ray crystal structure. J.Med.Chem., 55, 2012
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5HJY
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![BU of 5hjy by Molmil](/molmil-images/mine/5hjy) | Structure function studies of R. palustris RubisCO (I165T mutant; CABP-bound) | 分子名称: | 2-CARBOXYARABINITOL-1,5-DIPHOSPHATE, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Arbing, M.A, Shin, A, Cascio, D, Satagopan, S, North, J.A, Tabita, F.R. | 登録日 | 2016-01-13 | 公開日 | 2017-01-18 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure function studies of R. palustris RubisCO. To Be Published
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5I5S
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![BU of 5i5s by Molmil](/molmil-images/mine/5i5s) | |
5IIW
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![BU of 5iiw by Molmil](/molmil-images/mine/5iiw) | Corkscrew assembly of SOD1 residues 28-38 without potassium iodide | 分子名称: | Superoxide dismutase [Cu-Zn] | 著者 | Sangwan, S, Zhao, A, Sawaya, M.R, Eisenberg, D. | 登録日 | 2016-03-01 | 公開日 | 2017-06-28 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS). Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5I02
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![BU of 5i02 by Molmil](/molmil-images/mine/5i02) | tRNA guanine transglycosylase (TGT) in co-crystallized complex with 6-amino-4-{2-[(cyclohexylmethyl)amino]ethyl}-2-(methylamino)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | 分子名称: | 1,2-ETHANEDIOL, 6-amino-4-{2-[(cyclohexylmethyl)amino]ethyl}-2-(methylamino)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one, CHLORIDE ION, ... | 著者 | Ehrmann, F.R, Nguyen, D, Heine, A, Klebe, G. | 登録日 | 2016-02-03 | 公開日 | 2017-02-15 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Co-crystallization, Isothermal titration calorimetry and nanoESI-MS reveal dimer disturbing inhibitors To be Published
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5I33
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![BU of 5i33 by Molmil](/molmil-images/mine/5i33) | Unligated adenylosuccinate synthetase from Cryptococcus neoformans | 分子名称: | Adenylosuccinate synthetase | 著者 | Blundell, R.D, Williams, S.J, Ericsson, D, Fraser, J.A, Kobe, B. | 登録日 | 2016-02-09 | 公開日 | 2016-08-24 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Disruption of de Novo Adenosine Triphosphate (ATP) Biosynthesis Abolishes Virulence in Cryptococcus neoformans. Acs Infect Dis., 2, 2016
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4HWN
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![BU of 4hwn by Molmil](/molmil-images/mine/4hwn) | Crystal structure of the second Ig-C2 domain of human Fc-receptor like A (FCRLA), Isoform 9 [NYSGRC-005836] | 分子名称: | Fc receptor-like A | 著者 | Kumar, P.R, Ahmed, M, Bhosle, R, Calarese, D, Celikigil, A, Chan, M.K, Fiser, A, Garforth, S, Glenn, A.S, Hillerich, B, Khafizov, K, Love, J, Patel, H, Rubinstein, R, Seidel, R, Stead, M, Toro, R, Nathenson, S.G, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC), Atoms-to-Animals: The Immune Function Network (IFN) | 登録日 | 2012-11-08 | 公開日 | 2012-11-21 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.006 Å) | 主引用文献 | Crystal structure of the second Ig-C2 domain of the human Fc-receptor like A, Isoform 9 [NYSGRC-005836] to be published
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4HWU
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![BU of 4hwu by Molmil](/molmil-images/mine/4hwu) | Crystal structure of the Ig-C2 type 1 domain from mouse Fibroblast growth factor receptor 2 (FGFR2) [NYSGRC-005912] | 分子名称: | Fibroblast growth factor receptor 2 | 著者 | Kumar, P.R, Ahmed, M, Banu, R, Bhosle, R, Calarese, D, Celikigil, A, Chamala, S, Chan, M.K, Chowdhury, S, Fiser, A, Garforth, S, Glenn, A.S, Hillerich, B, Khafizov, K, Love, J, Patel, H, Rubinstein, R, Seidel, R, Stead, M, Toro, R, Nathenson, S.G, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC), Atoms-to-Animals: The Immune Function Network (IFN) | 登録日 | 2012-11-08 | 公開日 | 2012-11-21 | 実験手法 | X-RAY DIFFRACTION (2.903 Å) | 主引用文献 | Crystal structure of the Ig-C2 type 1 domain from mouse FGFR2 [NYSGRC-005912] to be published
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5IOO
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![BU of 5ioo by Molmil](/molmil-images/mine/5ioo) | Accommodation of massive sequence variation in Nanoarchaeota by the C-type lectin fold | 分子名称: | AvpA, MAGNESIUM ION | 著者 | Handa, S, Paul, B, Miller, J, Valentine, D, Ghosh, P. | 登録日 | 2016-03-08 | 公開日 | 2016-11-09 | 最終更新日 | 2019-12-11 | 実験手法 | X-RAY DIFFRACTION (2.521 Å) | 主引用文献 | Conservation of the C-type lectin fold for accommodating massive sequence variation in archaeal diversity-generating retroelements. Bmc Struct.Biol., 16, 2016
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5I34
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![BU of 5i34 by Molmil](/molmil-images/mine/5i34) | Adenylosuccinate synthetase from Cryptococcus neoformans complexed with GDP and IMP | 分子名称: | Adenylosuccinate synthetase, GUANOSINE-5'-DIPHOSPHATE, INOSINIC ACID | 著者 | Blundell, R.D, Williams, S.J, Ericsson, D, Fraser, J.A, Kobe, B. | 登録日 | 2016-02-09 | 公開日 | 2016-08-24 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | 主引用文献 | Disruption of de Novo Adenosine Triphosphate (ATP) Biosynthesis Abolishes Virulence in Cryptococcus neoformans. Acs Infect Dis., 2, 2016
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5IIS
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![BU of 5iis by Molmil](/molmil-images/mine/5iis) | Design, synthesis and structure activity relationship of potent pan-PIM kinase inhibitors derived from the pyridyl-amide scaffold | 分子名称: | 3-amino-N-(2'-amino-6'-methyl[4,4'-bipyridin]-3-yl)-6-(2-fluorophenyl)pyridine-2-carboxamide, DI(HYDROXYETHYL)ETHER, Serine/threonine-protein kinase pim-1 | 著者 | Bellamacina, C, Bussiere, D, Burger, M. | 登録日 | 2016-03-01 | 公開日 | 2016-04-06 | 最終更新日 | 2016-05-04 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Design, synthesis and structure activity relationship of potent pan-PIM kinase inhibitors derived from the pyridyl carboxamide scaffold. Bioorg.Med.Chem.Lett., 26, 2016
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4IM7
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![BU of 4im7 by Molmil](/molmil-images/mine/4im7) | Crystal structure of fructuronate reductase (ydfI) from E. coli CFT073 (EFI TARGET EFI-506389) complexed with NADH and D-mannonate | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, D-MANNONIC ACID, Hypothetical oxidoreductase ydfI, ... | 著者 | Lukk, T, Wichelecki, D, Imker, H.J, Gerlt, J.A, Nair, S.K. | 登録日 | 2013-01-02 | 公開日 | 2013-01-23 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure of fructuronate reductase (ydfI) from E. coli CFT073 (EFI TARGET EFI-506389) complexed with NADH and D-mannonate To be Published
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