5W07

CRYSTAL STRUCTURE OF THE INHA FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH AN12855, EBSI 4333.

Summary for 5W07

• Entry DOI: 10.2210/pdb5w07/pdb
• Descriptor: Enoyl-[acyl-carrier-protein] reductase [NADH], (~{N}~{E})-~{N}-[[2-[[2-ethylsulfonyl-1,1-bis(oxidanyl)-3,4-dihydro-2,3,1$l^{4}-benzodiazaborinin-7-yl]oxy]-5-(trifluoromethyl)phenyl]methylidene]hydroxylamine (3 entities in total)
• Functional Keywords: inha, enoyl-acyl reductase, tuberculosis, oxidoreductase
• Biological source: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
• Total number of polymer chains: 1
• Total formula weight: 29297.27

Authors

Abendroth, J.,Edwards, T.E.,Lorimer, D. (deposition date: 2017-05-30, release date: 2018-06-13, Last modification date: 2024-03-13)

• Primary citation: Alley, M.R.K.,Zhou, Y.; Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.65 Å)