5I02

tRNA guanine transglycosylase (TGT) in co-crystallized complex with 6-amino-4-{2-[(cyclohexylmethyl)amino]ethyl}-2-(methylamino)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one

Summary for 5I02

Related3EOS 4KWO 4LEQ 5100 4PUK 3GE7 1Y5X 1Y5W 1Y5V 4FSA 4FR6 1P0D
DescriptorQueuine tRNA-ribosyltransferase, ZINC ION, 6-amino-4-{2-[(cyclohexylmethyl)amino]ethyl}-2-(methylamino)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one, ... (7 entities in total)
Functional Keywordsco-crystallization, shigellosis, transferase, transferase inhibitor
Biological sourceZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Total number of polymer chains1
Total molecular weight43679.34
Authors
Ehrmann, F.R.,Nguyen, D.,Heine, A.,Klebe, G. (deposition date: 2016-02-03, release date: 2017-02-15)
Primary citation
Ehrmann, F.R.,Stojko, J.,Heine, A.,Diederich, F.,Reuter, K.,Sanglier-Cianferani, S.,Klebe, G.
Co-crystallization, Isothermal titration calorimetry and nanoESI-MS reveal dimer disturbing inhibitors
To be Published,
Experimental method
X-RAY DIFFRACTION (1.25 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.15820 1.9% 4.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-10-28