1B4K
 
 | | High resolution crystal structure of a MG2-dependent 5-aminolevulinic acid dehydratase | | Descriptor: | LAEVULINIC ACID, MAGNESIUM ION, PROTEIN (5-AMINOLEVULINIC ACID DEHYDRATASE), ... | | Authors: | Frankenberg, N, Jahn, D, Heinz, D.W. | | Deposit date: | 1998-12-22 | | Release date: | 1999-07-13 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (1.67 Å) | | Cite: | High resolution crystal structure of a Mg2+-dependent porphobilinogen synthase.
J.Mol.Biol., 289, 1999
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5XP1
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1AV3
 | | POTASSIUM CHANNEL BLOCKER KAPPA CONOTOXIN PVIIA FROM C. PURPURASCENS, NMR, 20 STRUCTURES | | Descriptor: | Kappa-conotoxin PVIIA | | Authors: | Scanlon, M.J, Naranjo, D, Thomas, L, Alewood, P.F, Lewis, R.J, Craik, D.J. | | Deposit date: | 1997-09-24 | | Release date: | 1998-10-14 | | Last modified: | 2020-12-16 | | Method: | SOLUTION NMR | | Cite: | Solution structure and proposed binding mechanism of a novel potassium channel toxin kappa-conotoxin PVIIA.
Structure, 5, 1997
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5XVU
 | | Crystal structure of the protein kinase CK2 catalytic domain from Plasmodium falciparum bound to ATP | | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ... | | Authors: | El Sahili, A, Lescar, J, Ruiz-Carrillo, D, Lin, J.Q. | | Deposit date: | 2017-06-28 | | Release date: | 2017-07-12 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | The protein kinase CK2 catalytic domain from Plasmodium falciparum: crystal structure, tyrosine kinase activity and inhibition.
Sci Rep, 8, 2018
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7YZ4
 | | Mouse endoribonuclease Dicer (composite structure) | | Descriptor: | Endoribonuclease Dicer | | Authors: | Zanova, M, Zapletal, D, Kubicek, K, Stefl, R, Pinkas, M, Novacek, J. | | Deposit date: | 2022-02-18 | | Release date: | 2022-11-16 | | Method: | ELECTRON MICROSCOPY (3.84 Å) | | Cite: | Structural and functional basis of mammalian microRNA biogenesis by Dicer.
Mol.Cell, 82, 2022
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6IC9
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7Z5X
 | | ROS1 with AstraZeneca ligand 2 | | Descriptor: | (2R)-2-[5-(6-amino-5-{(1R)-1-[2-(1,3-dihydro-2H-1,2,3-triazol-2-yl)-5-fluorophenyl]ethoxy}pyridin-3-yl)-4-methyl-1,3-thiazol-2-yl]propane-1,2-diol, Proto-oncogene tyrosine-protein kinase ROS | | Authors: | Hargreaves, D. | | Deposit date: | 2022-03-10 | | Release date: | 2022-08-17 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.035 Å) | | Cite: | Virtual Screening in the Cloud Identifies Potent and Selective ROS1 Kinase Inhibitors.
J.Chem.Inf.Model., 62, 2022
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1B5K
 | | 3,N4-ETHENO-2'-DEOXYCYTIDINE OPPOSITE THYMIDINE IN AN 11-MER DUPLEX, SOLUTION STRUCTURE FROM NMR AND MOLECULAR DYNAMICS | | Descriptor: | DNA (5'-D(*CP*GP*TP*AP*CP*EDCP*CP*AP*TP*GP*C)-3'), DNA (5'-D(*GP*CP*AP*TP*GP*TP*GP*TP*AP*CP*G)-3') | | Authors: | Cullinan, D, Korobka, A, Grollman, A.P, Patel, D.J, Eisenberg, M, De Santos, C.L. | | Deposit date: | 1999-01-07 | | Release date: | 1999-01-13 | | Last modified: | 2023-12-27 | | Method: | SOLUTION NMR | | Cite: | NMR solution structure of an oligodeoxynucleotide duplex containing the exocyclic lesion 3,N4-etheno-2'-deoxycytidine opposite thymidine: comparison with the duplex containing deoxyadenosine opposite the adduct.
Biochemistry, 35, 1996
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1B8Y
 | | X-RAY STRUCTURE OF HUMAN STROMELYSIN CATALYTIC DOMAIN COMPLEXED WITH NON-PEPTIDE INHIBITORS: IMPLICATIONS FOR INHIBITOR SELECTIVITY | | Descriptor: | CALCIUM ION, PROTEIN (STROMELYSIN-1), SULFATE ION, ... | | Authors: | Pavlovsky, A.G, Williams, M.G, Ye, Q.-Z, Ortwine, D.F, Purchase II, C.F, White, A.D, Dhanaraj, V, Roth, B.D, Johnson, L.L, Hupe, D, Humblet, C, Blundell, T.L. | | Deposit date: | 1999-02-03 | | Release date: | 1999-08-31 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | X-ray structure of human stromelysin catalytic domain complexed with nonpeptide inhibitors: implications for inhibitor selectivity.
Protein Sci., 8, 1999
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7YYM
 | | Mammalian Dicer in the "pre-dicing state" with pre-miR-15a substrate | | Descriptor: | 59-nt precursor of miR-15a, Endoribonuclease Dicer | | Authors: | Zanova, M, Zapletal, D, Kubicek, K, Stefl, R, Pinkas, M, Novacek, J. | | Deposit date: | 2022-02-18 | | Release date: | 2022-11-16 | | Method: | ELECTRON MICROSCOPY (4.19 Å) | | Cite: | Structural and functional basis of mammalian microRNA biogenesis by Dicer.
Mol.Cell, 82, 2022
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1B8W
 | | DEFENSIN-LIKE PEPTIDE 1 | | Descriptor: | PROTEIN (DEFENSIN-LIKE PEPTIDE 1) | | Authors: | Torres, A.M, Wang, X, Fletcher, J.I, Alewood, D, Alewood, P.F, Smith, R, Simpson, R.J, Nicholson, G.M, Sutherland, S.K, Gallagher, C.H, King, G.F, Kuchel, P.W. | | Deposit date: | 1999-02-02 | | Release date: | 1999-09-15 | | Last modified: | 2023-12-27 | | Method: | SOLUTION NMR | | Cite: | Solution structure of a defensin-like peptide from platypus venom.
Biochem.J., 341, 1999
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7YYN
 | | Mammalian Dicer in the dicing state with pre-miR-15a substrate | | Descriptor: | 59-nt precursor of miR-15a, Isoform 2 of Endoribonuclease Dicer | | Authors: | Zanova, M, Zapletal, D, Kubicek, K, Stefl, R, Pinkas, M, Novacek, J. | | Deposit date: | 2022-02-18 | | Release date: | 2022-11-16 | | Method: | ELECTRON MICROSCOPY (6.21 Å) | | Cite: | Structural and functional basis of mammalian microRNA biogenesis by Dicer.
Mol.Cell, 82, 2022
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8C7G
 | | Drosophila melanogaster Rab7 GEF complex Mon1-Ccz1-Bulli | | Descriptor: | Caffeine, calcium, zinc sensitivity 1, ... | | Authors: | Schaefer, J, Herrmann, E, Kuemmel, D, Moeller, A. | | Deposit date: | 2023-01-15 | | Release date: | 2023-05-17 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structure of the metazoan Rab7 GEF complex Mon1-Ccz1-Bulli.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8CPO
 | | Crystal structure of the PolB16_OarG intein variant S1A, N183A, C111A, C165A | | Descriptor: | PolB16 Intein Cys-less | | Authors: | Kattelmann, S, Pasch, T, Mootz, H.D, Kuemmel, D. | | Deposit date: | 2023-03-03 | | Release date: | 2023-05-17 | | Last modified: | 2024-06-19 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural and biochemical analysis of a novel atypically split intein reveals a conserved histidine specific to cysteine-less inteins.
Chem Sci, 14, 2023
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1BH1
 | | STRUCTURAL STUDIES OF D-PRO MELITTIN, NMR, 20 STRUCTURES | | Descriptor: | MELITTIN | | Authors: | Barnham, K.J, Hewish, D, Werkmeister, J, Curtain, C, Kirkpatrick, A, Bartone, N, Liu, S.T, Norton, R, Rivett, D. | | Deposit date: | 1998-06-11 | | Release date: | 1999-01-06 | | Last modified: | 2022-02-16 | | Method: | SOLUTION NMR | | Cite: | Structure and activity of D-Pro14 melittin.
J.Protein Chem., 21, 2002
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7Z5W
 | | ROS1 with AstraZeneca ligand 1 | | Descriptor: | Proto-oncogene tyrosine-protein kinase ROS, SULFATE ION, ~{N}-[6-methyl-2-[(2~{S})-2-[3-(3-methylpyrazin-2-yl)-1,2-oxazol-5-yl]pyrrolidin-1-yl]pyrimidin-4-yl]-1,3-thiazol-2-amine | | Authors: | Hargreaves, D. | | Deposit date: | 2022-03-10 | | Release date: | 2022-08-17 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.254 Å) | | Cite: | Virtual Screening in the Cloud Identifies Potent and Selective ROS1 Kinase Inhibitors.
J.Chem.Inf.Model., 62, 2022
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7SHQ
 | | Structure of a functional construct of eukaryotic elongation factor 2 kinase in complex with calmodulin. | | Descriptor: | CALCIUM ION, Calmodulin-1, Eukaryotic elongation factor 2 kinase,Eukaryotic elongation factor 2 kinase, ... | | Authors: | Piserchio, A, Isiorho, E.A, Jeruzalmi, D, Dalby, K.N, Ghose, R. | | Deposit date: | 2021-10-11 | | Release date: | 2022-04-06 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.34 Å) | | Cite: | Structural basis for the calmodulin-mediated activation of eukaryotic elongation factor 2 kinase.
Sci Adv, 8, 2022
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1BH0
 | | STRUCTURE OF A GLUCAGON ANALOG | | Descriptor: | GLUCAGON | | Authors: | Sturm, N.S, Lin, Y, Burley, S.K, Krstenansky, J.L, Ahn, J.-M, Azizeh, B.Y, Trivedi, D, Hruby, V.J. | | Deposit date: | 1998-06-11 | | Release date: | 1998-11-04 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structure-function studies on positions 17, 18, and 21 replacement analogues of glucagon: the importance of charged residues and salt bridges in glucagon biological activity.
J.Med.Chem., 41, 1998
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1BH9
 | | HTAFII18/HTAFII28 HETERODIMER CRYSTAL STRUCTURE WITH BOUND PCMBS | | Descriptor: | PARA-MERCURY-BENZENESULFONIC ACID, TAFII18, TAFII28 | | Authors: | Birck, C, Poch, O, Romier, C, Ruff, M, Mengus, G, Lavigne, A.-C, Davidson, I, Moras, D. | | Deposit date: | 1998-06-16 | | Release date: | 1999-06-22 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Human TAF(II)28 and TAF(II)18 interact through a histone fold encoded by atypical evolutionary conserved motifs also found in the SPT3 family.
Cell(Cambridge,Mass.), 94, 1998
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1BC6
 | | 7-FE FERREDOXIN FROM BACILLUS SCHLEGELII, NMR, 20 STRUCTURES | | Descriptor: | 7-FE FERREDOXIN, FE3-S4 CLUSTER, IRON/SULFUR CLUSTER | | Authors: | Aono, S, Bentrop, D, Bertini, I, Donaire, A, Luchinat, C, Niikura, Y, Rosato, A. | | Deposit date: | 1998-05-05 | | Release date: | 1998-06-17 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the oxidized Fe7S8 ferredoxin from the thermophilic bacterium Bacillus schlegelii by 1H NMR spectroscopy.
Biochemistry, 37, 1998
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5XR1
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1BF5
 | | TYROSINE PHOSPHORYLATED STAT-1/DNA COMPLEX | | Descriptor: | DNA (5'-D(*AP*CP*AP*GP*TP*TP*TP*CP*CP*CP*GP*TP*AP*AP*AP*TP*G P*C)-3'), DNA (5'-D(*TP*GP*CP*AP*TP*TP*TP*AP*CP*GP*GP*GP*AP*AP*AP*CP*T P*G)-3'), SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA | | Authors: | Kuriyan, J, Zhao, Y, Chen, X, Vinkemeier, U, Jeruzalmi, D, Darnell Jr, J.E. | | Deposit date: | 1998-05-27 | | Release date: | 1998-08-12 | | Last modified: | 2022-12-21 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA.
Cell(Cambridge,Mass.), 93, 1998
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1BG7
 | | LOCALIZED UNFOLDING AT THE JUNCTION OF THREE FERRITIN SUBUNITS. A MECHANISM FOR IRON RELEASE? | | Descriptor: | CALCIUM ION, FERRITIN | | Authors: | Takagi, H, Shi, D, Ha, Y, Allewell, N.M, Theil, E.C. | | Deposit date: | 1998-06-05 | | Release date: | 1999-01-13 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Localized unfolding at the junction of three ferritin subunits. A mechanism for iron release?
J.Biol.Chem., 273, 1998
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5XYZ
 | | The structure of human BTK kinase domain in complex with a covalent inhibitor | | Descriptor: | N-[3-(5-{[(2-chloro-6-fluorophenyl)methyl]amino}-1H-1,2,4-triazol-3-yl)phenyl]propanamide, Tyrosine-protein kinase BTK | | Authors: | Wang, Y.L, Sun, Y.Z, Cao, R, Liu, D, Xie, Y.T, Li, L, Qi, X.B, Huang, N. | | Deposit date: | 2017-07-11 | | Release date: | 2018-05-23 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.64 Å) | | Cite: | In Silico Identification of a Novel Hinge-Binding Scaffold for Kinase Inhibitor Discovery.
J. Med. Chem., 60, 2017
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5Y6A
 | | Crystal structure of the anti-CRISPR protein, AcrIIA1 | | Descriptor: | chain A and B | | Authors: | Ka, D, An, S.Y, Suh, J.Y, Bae, E. | | Deposit date: | 2017-08-11 | | Release date: | 2017-11-29 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of an anti-CRISPR protein, AcrIIA1
Nucleic Acids Res., 46, 2018
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