7YYM
Mammalian Dicer in the "pre-dicing state" with pre-miR-15a substrate
Summary for 7YYM
Entry DOI | 10.2210/pdb7yym/pdb |
EMDB information | 14383 |
Descriptor | Endoribonuclease Dicer, 59-nt precursor of miR-15a (2 entities in total) |
Functional Keywords | endoribonuclease, dsrna, complex, gene silencing, post-transcriptional, catalytic complex, cytoplasm, rna binding protein |
Biological source | Mus musculus (house mouse) More |
Total number of polymer chains | 2 |
Total formula weight | 245826.87 |
Authors | Zanova, M.,Zapletal, D.,Kubicek, K.,Stefl, R.,Pinkas, M.,Novacek, J. (deposition date: 2022-02-18, release date: 2022-11-16, Last modification date: 2024-07-17) |
Primary citation | Zapletal, D.,Taborska, E.,Pasulka, J.,Malik, R.,Kubicek, K.,Zanova, M.,Much, C.,Sebesta, M.,Buccheri, V.,Horvat, F.,Jenickova, I.,Prochazkova, M.,Prochazka, J.,Pinkas, M.,Novacek, J.,Joseph, D.F.,Sedlacek, R.,Bernecky, C.,O'Carroll, D.,Stefl, R.,Svoboda, P. Structural and functional basis of mammalian microRNA biogenesis by Dicer. Mol.Cell, 82:4064-4079.e13, 2022 Cited by PubMed: 36332606DOI: 10.1016/j.molcel.2022.10.010 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (4.19 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)