7YYM
Mammalian Dicer in the "pre-dicing state" with pre-miR-15a substrate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Endoribonuclease Dicer | polymer | 2004 | 226809.6 | 1 | UniProt (Q8R418) Pfam (PF04851) Pfam (PF20930) Pfam (PF00271) Pfam (PF03368) Pfam (PF20931) Pfam (PF02170) Pfam (PF00636) Pfam (PF20932) | Mus musculus (house mouse) | Double-strand-specific ribonuclease mDCR-1 |
| 2 | B (B) | 59-nt precursor of miR-15a | polymer | 59 | 19017.3 | 1 | synthetic construct |
Sequence modifications
A: 1 - 1916 (UniProt: Q8R418)
| PDB | External Database | Details |
|---|---|---|
| Met -52 | - | initiating methionine |
| Val -51 | - | expression tag |
| Trp -50 | - | expression tag |
| Ser -49 | - | expression tag |
| His -48 | - | expression tag |
| Pro -47 | - | expression tag |
| Gln -46 | - | expression tag |
| Phe -45 | - | expression tag |
| Glu -44 | - | expression tag |
| Lys -43 | - | expression tag |
| Gly -42 | - | expression tag |
| Gly -41 | - | expression tag |
| Gly -40 | - | expression tag |
| Ser -39 | - | expression tag |
| Gly -38 | - | expression tag |
| Gly -37 | - | expression tag |
| Gly -36 | - | expression tag |
| Ser -35 | - | expression tag |
| Gly -34 | - | expression tag |
| Gly -33 | - | expression tag |
| Ser -32 | - | expression tag |
| Ala -31 | - | expression tag |
| Trp -30 | - | expression tag |
| Ser -29 | - | expression tag |
| His -28 | - | expression tag |
| Pro -27 | - | expression tag |
| Gln -26 | - | expression tag |
| Phe -25 | - | expression tag |
| Glu -24 | - | expression tag |
| Lys -23 | - | expression tag |
| Gly -22 | - | expression tag |
| Asp -21 | - | expression tag |
| Tyr -20 | - | expression tag |
| Pro -19 | - | expression tag |
| Tyr -18 | - | expression tag |
| Asp -17 | - | expression tag |
| Val -16 | - | expression tag |
| Pro -15 | - | expression tag |
| Asp -14 | - | expression tag |
| Tyr -13 | - | expression tag |
| Ala -12 | - | expression tag |
| Gly -11 | - | expression tag |
| Thr -10 | - | expression tag |
| Glu -9 | - | expression tag |
| Asn -8 | - | expression tag |
| Leu -7 | - | expression tag |
| Tyr -6 | - | expression tag |
| Phe -5 | - | expression tag |
| Gln -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Leu -2 | - | expression tag |
| Val -1 | - | expression tag |
| Asp 0 | - | expression tag |
| Ser 1110 | Thr 1110 | conflict |
| Ala 1560 | Glu 1560 | engineered mutation |
| Ser 1619 | Ala 1619 | conflict |
| Ala 1807 | Glu 1807 | engineered mutation |
| Gly 1917 | - | expression tag |
| Arg 1918 | - | expression tag |
| Gly 1919 | - | expression tag |
| Glu 1920 | - | expression tag |
| Asn 1921 | - | expression tag |
| Leu 1922 | - | expression tag |
| Tyr 1923 | - | expression tag |
| Phe 1924 | - | expression tag |
| Gln 1925 | - | expression tag |
| Gly 1926 | - | expression tag |
| Ala 1927 | - | expression tag |
| Ser 1928 | - | expression tag |
| Asp 1929 | - | expression tag |
| Tyr 1930 | - | expression tag |
| Lys 1931 | - | expression tag |
| Asp 1932 | - | expression tag |
| His 1933 | - | expression tag |
| Asp 1934 | - | expression tag |
| Gly 1935 | - | expression tag |
| Asp 1936 | - | expression tag |
| Tyr 1937 | - | expression tag |
| Lys 1938 | - | expression tag |
| Asp 1939 | - | expression tag |
| His 1940 | - | expression tag |
| Asp 1941 | - | expression tag |
| Gly 1942 | - | expression tag |
| Ser 1943 | - | expression tag |
| His 1944 | - | expression tag |
| His 1945 | - | expression tag |
| His 1946 | - | expression tag |
| His 1947 | - | expression tag |
| His 1948 | - | expression tag |
| His 1949 | - | expression tag |
| His 1950 | - | expression tag |
| His 1951 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 245826.9 | |
| All* | Total formula weight | 245826.9 |
