6IC9

Crystal structure of the SPOC domain of human PHF3 in complex with RNA polymerase II CTD diheptapeptide phosphorylated on Ser2Ser7

Summary for 6IC9

• Entry DOI: 10.2210/pdb6ic9/pdb
• Related: 6IC8
• Descriptor: PHD finger protein 3, TYR-SEP-PRO-THR-SER-PRO-SEP-TYR-SEP-PRO-THR-SER-PRO (3 entities in total)
• Functional Keywords: spoc domain, phf3, pser2 peptide, transcription
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 39977.12

Authors

Grishkovskaya, I.,Djinovic-Carugo, K.,Slade, D. (deposition date: 2018-12-03, release date: 2020-07-15, Last modification date: 2021-10-27)

• Primary citation: Appel, L.M.,Franke, V.,Bruno, M.,Grishkovskaya, I.,Kasiliauskaite, A.,Kaufmann, T.,Schoeberl, U.E.,Puchinger, M.G.,Kostrhon, S.,Ebenwaldner, C.,Sebesta, M.,Beltzung, E.,Mechtler, K.,Lin, G.,Vlasova, A.,Leeb, M.,Pavri, R.,Stark, A.,Akalin, A.,Stefl, R.,Bernecky, C.,Djinovic-Carugo, K.,Slade, D.; PHF3 regulates neuronal gene expression through the Pol II CTD reader domain SPOC; Nat Commun, 12:6078-, 2021; DOI: 10.1038/s41467-021-26360-2

Experimental method

X-RAY DIFFRACTION (1.748 Å)