5M37
| The molecular tweezer CLR01 stabilizes a disordered protein-protein interface | 分子名称: | (1R,5S,9S,16R,20R,24S,28S,35R)-3,22-Bis(dihydroxyphosphoryloxy)tridecacyclo[22.14.1.15,20.19,16.128,35.02,23.04,21.06,19.08,17.010,15.025,38.027,36.029,34]dotetraconta-2(23),3,6,8(17),10,12,14,18,21,25,27(36),29,31,33,37-pentadecaene, 14-3-3 protein zeta/delta, BENZOIC ACID, ... | 著者 | Bier, D, Ottmann, C. | 登録日 | 2016-10-14 | 公開日 | 2017-11-15 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | The Molecular Tweezer CLR01 Stabilizes a Disordered Protein-Protein Interface. J. Am. Chem. Soc., 139, 2017
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6ZHN
| 3D electron diffraction structure of thaumatin from Thaumatococcus daniellii | 分子名称: | CHLORIDE ION, Thaumatin-1 | 著者 | Blum, T, Housset, D, Clabbers, M.T.B, van Genderen, E, Schoehn, G, Ling, W.L, Abrahams, J.P. | 登録日 | 2020-06-23 | 公開日 | 2021-01-27 | 最終更新日 | 2024-01-24 | 実験手法 | ELECTRON CRYSTALLOGRAPHY (2.76 Å) | 主引用文献 | Statistically correcting dynamical electron scattering improves the refinement of protein nanocrystals, including charge refinement of coordinated metals. Acta Crystallogr D Struct Biol, 77, 2021
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5UOP
| CRYSTAL STRUCTURE OF THE PROTOTYPE FOAMY VIRUS INTASOME WITH A 2- PYRIDINONE AMINAL INHIBITOR (COMPOUND 18) | 分子名称: | (1S,2S,5R)-8'-[(3-chloro-4-fluorophenyl)methyl]-2'-[2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl]-6'-hydroxy-9',10'-dihydro-2'H-spiro[bicyclo[3.1.0]hexane-2,3'-imidazo[5,1-a][2,6]naphthyridine]-1',5',7'(8'H)-trione, GLYCEROL, INTEGRASE, ... | 著者 | Klein, D.J. | 登録日 | 2017-02-01 | 公開日 | 2017-03-29 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Discovery and optimization of 2-pyridinone aminal integrase strand transfer inhibitors for the treatment of HIV. Bioorg. Med. Chem. Lett., 27, 2017
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1B3U
| CRYSTAL STRUCTURE OF CONSTANT REGULATORY DOMAIN OF HUMAN PP2A, PR65ALPHA | 分子名称: | PROTEIN (PROTEIN PHOSPHATASE PP2A) | 著者 | Groves, M.R, Hanlon, N, Turowski, P, Hemmings, B, Barford, D. | 登録日 | 1998-12-14 | 公開日 | 1999-04-12 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs. Cell(Cambridge,Mass.), 96, 1999
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1AZ1
| ALRESTATIN BOUND TO C298A/W219Y MUTANT HUMAN ALDOSE REDUCTASE | 分子名称: | ALDOSE REDUCTASE, ALRESTATIN, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Harrison, D.H.T, Bohren, K.M, Petsko, G.A, Ringe, D, Gabbay, K.H. | 登録日 | 1997-11-24 | 公開日 | 1998-03-18 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | The alrestatin double-decker: binding of two inhibitor molecules to human aldose reductase reveals a new specificity determinant. Biochemistry, 36, 1997
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8XLD
| Structure of the GFP:GFP-nanobody complex from Biortus. | 分子名称: | 1,2-ETHANEDIOL, Nanobody(Staygold-S2G10)-Nanobody(Staygold-S4F1), ZINC ION, ... | 著者 | Wang, F, Cheng, W, Yuan, Z, Lin, D, Bao, C. | 登録日 | 2023-12-25 | 公開日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure of the GFP:GFP-nanobody complex from Biortus. To Be Published
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6QJ5
| X-ray structure of PPARgamma LBD with the ligand NV1380 | 分子名称: | (2~{S})-3-methyl-2-[(4-octoxyphenyl)carbonylamino]butanoic acid, Peroxisome proliferator-activated receptor gamma | 著者 | Pochetti, G, Montanari, R, Capelli, D. | 登録日 | 2019-01-22 | 公開日 | 2020-02-05 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A Novel N-Substituted Valine Derivative with Unique Peroxisome Proliferator-Activated Receptor gamma Binding Properties and Biological Activities. J.Med.Chem., 63, 2020
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6BUH
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6N8F
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8YQ4
| Structure of mBaoJin2 | 分子名称: | CHLORIDE ION, GLYCEROL, SULFATE ION, ... | 著者 | Boyko, K.M, Nikolaeva, A.Y, Minyaev, M.E, Kuzmicheva, T.P, Vlaskina, A.V, Popov, V.O, Pyatkevich, K.D, Subach, F.V. | 登録日 | 2024-03-19 | 公開日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure of mBaoJin2 To Be Published
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8CGE
| The crystal structure of a cobalt-bound scFv reveals a Tetrameric polyHistidine motif (TetrHis) | 分子名称: | 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, COBALT (II) ION, SULFATE ION, ... | 著者 | Healey, R.D, Hoh, F, Granier, S, Leyrat, C. | 登録日 | 2023-02-03 | 公開日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure, dynamics and transferability of the metal-dependent polyhistidine tetramerization motif TetrHis for single-chain Fv antibodies. Commun Chem, 6, 2023
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8RU1
| Chromatin remodeling regulator CECR2 with in crystallo disulfide bond | 分子名称: | Chromatin remodeling regulator CECR2, GLYCEROL, SODIUM ION | 著者 | Fairhead, M, Strain-Damerell, C, Ye, M, Mackinnon, S.R, Pinkas, D, MacLean, E.M, Koekemoer, L, Damerell, D, Krojer, T, Arrowsmith, C.H, Edwards, A, Bountra, C, Yue, W, Burgess-Brown, N, Marsden, B, von Delft, F, Structural Genomics Consortium (SGC) | 登録日 | 2024-01-29 | 公開日 | 2024-03-06 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | 主引用文献 | A fast, parallel method for efficiently exploring crystallization behaviour of large numbers of protein variants To Be Published
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6ZCM
| Crystal structure of YTHDC1 with compound DHU_DC1_180 | 分子名称: | 6-[[cyclopropyl-[(7-methoxy-1,3-benzodioxol-5-yl)methyl]amino]methyl]-1~{H}-pyrimidine-2,4-dione, SULFATE ION, YTHDC1 | 著者 | Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A. | 登録日 | 2020-06-11 | 公開日 | 2020-07-29 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.24 Å) | 主引用文献 | Atomistic and Thermodynamic Analysis of N6-Methyladenosine (m 6 A) Recognition by the Reader Domain of YTHDC1. J Chem Theory Comput, 17, 2021
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4RXW
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8OWK
| Lipidic amyloid-beta(1-40) fibril - polymorph L3-L3 | 分子名称: | Amyloid-beta A4 protein | 著者 | Frieg, B, Han, M, Giller, K, Dienemann, C, Riedel, D, Becker, S, Andreas, L.B, Griesinger, C, Schroeder, G.F. | 登録日 | 2023-04-28 | 公開日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.86 Å) | 主引用文献 | Cryo-EM structures of lipidic fibrils of amyloid-beta (1-40). Nat Commun, 15, 2024
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8C2H
| Transmembrane domain of active state homomeric GluA1 AMPA receptor in tandem with TARP gamma 3 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Glutamate receptor 1 flip isoform, ... | 著者 | Zhang, D, Ivica, J, Krieger, J.M, Ho, H, Yamashita, K, Cais, O, Greger, I. | 登録日 | 2022-12-22 | 公開日 | 2023-08-30 | 最終更新日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (2.64 Å) | 主引用文献 | Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor. Nature, 621, 2023
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6C4P
| Crystal Structures of Cystathionine beta-Synthase from Saccharomyces cerevisiae: the Structure of the PMP Complex | 分子名称: | 1,2-ETHANEDIOL, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, CALCIUM ION, ... | 著者 | Kreinbring, C.A, Tu, Y, Liu, D, Berkowitz, D.B, Petsko, G.A, Ringe, D. | 登録日 | 2018-01-12 | 公開日 | 2018-04-25 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal Structures of Cystathionine beta-Synthase from Saccharomyces cerevisiae: One Enzymatic Step at a Time. Biochemistry, 57, 2018
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7ICD
| REGULATION OF AN ENZYME BY PHOSPHORYLATION AT THE ACTIVE SITE | 分子名称: | ISOCITRATE DEHYDROGENASE | 著者 | Hurley, J.H, Dean, A.M, Sohl, J.L, Koshlandjunior, D.E, Stroud, R.M. | 登録日 | 1990-05-30 | 公開日 | 1991-10-15 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Regulation of an enzyme by phosphorylation at the active site. Science, 249, 1990
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8C1P
| Active state homomeric GluA1 AMPA receptor in complex with TARP gamma 3 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CYCLOTHIAZIDE, ... | 著者 | Zhang, D, Ivica, J, Krieger, J.M, Ho, H, Yamashita, K, Cais, O, Greger, I. | 登録日 | 2022-12-21 | 公開日 | 2023-08-30 | 最終更新日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor. Nature, 621, 2023
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8CIJ
| CRYSTAL STRUCTURE OF HUMAN HPK1 (MAP4K1) COMPLEX WITH 2-[8-Amino-7-fluoro-6-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-isoquinolin-3-ylamino]-6-isopropyl-5,6-dihydro-4H-1,6,8a-triaza-azulen-7-one | 分子名称: | 2-[[8-azanyl-7-fluoranyl-6-(8-methyl-2,3-dihydro-1~{H}-pyrido[2,3-b][1,4]oxazin-7-yl)isoquinolin-3-yl]amino]-6-propan-2-yl-5,8-dihydro-4~{H}-pyrazolo[1,5-d][1,4]diazepin-7-one, Mitogen-activated protein kinase kinase kinase kinase 1 | 著者 | Musil, D, Toure, M. | 登録日 | 2023-02-09 | 公開日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.821 Å) | 主引用文献 | Discovery of quinazoline HPK1 inhibitors with high cellular potency. Bioorg.Med.Chem., 92, 2023
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6SQR
| Crystal structure of Cat MDM2-S429E RING domain bound to UbcH5B-Ub | 分子名称: | 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase Mdm2, NITRATE ION, ... | 著者 | Magnussen, H.M, Ahmed, S.F, Huang, D.T. | 登録日 | 2019-09-04 | 公開日 | 2020-05-06 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | 主引用文献 | Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain. Nat Commun, 11, 2020
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8RXR
| Crystal structure of VPS34 in complex with inhibitor SB02024 | 分子名称: | 4-[(3R)-3-methylmorpholin-4-yl]-2-[(2R)-2-(trifluoromethyl)piperidin-1-yl]-3H-pyridin-6-one, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | 著者 | Tresaugues, L, Yu, Y, Bogdan, M, Parpal, S, Silvander, C, Lindstrom, J, Simeon, J, Timson, M.J, Al-Hashimi, H, Smith, B.D, Flynn, D.L, Viklund, J, Martinsson, J, De Milito, A, Andersson, M. | 登録日 | 2024-02-07 | 公開日 | 2024-03-20 | 最終更新日 | 2024-08-21 | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | 主引用文献 | Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti-tumor efficacy. Mol Oncol, 18, 2024
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8C2I
| Transmembrane domain of resting state homomeric GluA1 AMPA receptor in complex with TARP gamma 3 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Glutamate receptor 1 flip isoform, ... | 著者 | Zhang, D, Ivica, J, Krieger, J.M, Ho, H, Yamashita, K, Cais, O, Greger, I. | 登録日 | 2022-12-22 | 公開日 | 2023-08-30 | 最終更新日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor. Nature, 621, 2023
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6C1S
| Phosphoinositide 3-Kinase gamma bound to an pyrrolopyridinone Inhibitor | 分子名称: | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, {4-[2-(5,6-dimethoxypyridin-3-yl)-5-oxo-5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-1H-pyrazol-1-yl}acetonitrile | 著者 | Jacobs, M.D, Griffin, J.P. | 登録日 | 2018-01-05 | 公開日 | 2018-06-27 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3-Kinase gamma (PI3K gamma ) Inhibitors with Potential for the Treatment of Multiple Sclerosis (MS). J. Med. Chem., 61, 2018
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8C1S
| Transmembrane domain of resting state homomeric GluA2 F231A mutant AMPA receptor in complex with TARP gamma 2 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Glutamate receptor 2, ... | 著者 | Zhang, D, Ivica, J, Krieger, J.M, Ho, H, Yamashita, K, Cais, O, Greger, I. | 登録日 | 2022-12-21 | 公開日 | 2023-08-30 | 最終更新日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor. Nature, 621, 2023
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