5UOP
CRYSTAL STRUCTURE OF THE PROTOTYPE FOAMY VIRUS INTASOME WITH A 2- PYRIDINONE AMINAL INHIBITOR (COMPOUND 18)
Summary for 5UOP
Entry DOI | 10.2210/pdb5uop/pdb |
Related | 5uoq |
Descriptor | INTEGRASE, NUCLEOTIDE PREPROCESSED PFV DONOR DNA (NON-TRANSFERRED STRAND), NUCLEOTIDE PREPROCESSED PFV DONOR DNA (TRANSFERRED STRAND), ... (9 entities in total) |
Functional Keywords | dna integration, viral protein, recombination-inhibitor-dna complex, transferase-dna-inhibitor complex, transferase/dna/inhibitor |
Biological source | Human spumaretrovirus (SFVcpz(hu)) More |
Cellular location | Integrase: Virion . Protease/Reverse transcriptase/ribonuclease H: Host nucleus : P14350 |
Total number of polymer chains | 4 |
Total formula weight | 101397.53 |
Authors | Klein, D.J. (deposition date: 2017-02-01, release date: 2017-03-29, Last modification date: 2024-03-06) |
Primary citation | Schreier, J.D.,Embrey, M.W.,Raheem, I.T.,Barbe, G.,Campeau, L.C.,Dubost, D.,McCabe Dunn, J.,Grobler, J.,Hartingh, T.J.,Hazuda, D.J.,Klein, D.,Miller, M.D.,Moore, K.P.,Nguyen, N.,Pajkovic, N.,Powell, D.A.,Rada, V.,Sanders, J.M.,Sisko, J.,Steele, T.G.,Wai, J.,Walji, A.,Xu, M.,Coleman, P.J. Discovery and optimization of 2-pyridinone aminal integrase strand transfer inhibitors for the treatment of HIV. Bioorg. Med. Chem. Lett., 27:2038-2046, 2017 Cited by PubMed: 28285916DOI: 10.1016/j.bmcl.2017.02.039 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.85 Å) |
Structure validation
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