5LO0
 
 | | HSP90 WITH indazole derivative | | 分子名称: | Heat shock protein HSP 90-alpha, [2-azanyl-6-[4,5-bis(fluoranyl)-2-(4-methylpiperazin-1-yl)sulfonyl-phenyl]quinazolin-4-yl]-(1,3-dihydroisoindol-2-yl)methanone | | 著者 | Graedler, U, Amaral, M, Schuetz, D. | | 登録日 | 2016-08-08 | | 公開日 | 2017-11-29 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Ligand Desolvation Steers On-Rate and Impacts Drug Residence Time of Heat Shock Protein 90 (Hsp90) Inhibitors.
J. Med. Chem., 61, 2018
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8OIV
 | | Monkeypox virus VP39 in complex with SAH and cap0 | | 分子名称: | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, ... | | 著者 | Skvara, P, Chalupska, D, Silhan, J, Klima, M, Boura, E. | | 登録日 | 2023-03-23 | | 公開日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | | 主引用文献 | Structural basis for RNA-cap recognition and methylation by the mpox methyltransferase VP39.
Antiviral Res., 216, 2023
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7SKI
 | | Pertussis toxin in complex with PJ34 | | 分子名称: | N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE, Pertussis toxin subunit 1 | | 著者 | Littler, D.R, Beddoe, T, Pulliainen, A, Rossjohn, J. | | 登録日 | 2021-10-20 | | 公開日 | 2022-04-13 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.09912443 Å) | | 主引用文献 | Crystal structures of pertussis toxin with NAD + and analogs provide structural insights into the mechanism of its cytosolic ADP-ribosylation activity.
J.Biol.Chem., 298, 2022
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7RZW
 | | CryoEM structure of Arabidopsis thaliana phytochrome B | | 分子名称: | 3-[5-[[(3~{R},4~{R})-3-ethyl-4-methyl-5-oxidanylidene-3,4-dihydropyrrol-2-yl]methyl]-2-[[5-[(4-ethyl-3-methyl-5-oxidanylidene-pyrrol-2-yl)methyl]-3-(3-hydroxy-3-oxopropyl)-4-methyl-1~{H}-pyrrol-2-yl]methyl]-4-methyl-1~{H}-pyrrol-3-yl]propanoic acid, Phytochrome B | | 著者 | Li, H, Burgie, E.S, Vierstra, R.D, Li, H. | | 登録日 | 2021-08-27 | | 公開日 | 2022-04-13 | | 最終更新日 | 2022-04-20 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Plant phytochrome B is an asymmetric dimer with unique signalling potential.
Nature, 604, 2022
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6M53
 | | Crystal structure of 2, 3-dihydroxybenzoic acid decarboxylase from Fusarium oxysporum | | 分子名称: | 2,3-dihydroxybenzoate decarboxylase, GLYCEROL, ZINC ION | | 著者 | Song, M.K, Feng, J.H, Liu, W.D, Wu, Q.Q, Zhu, D.M. | | 登録日 | 2020-03-09 | | 公開日 | 2020-07-15 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | 2,3-Dihydroxybenzoic Acid Decarboxylase from Fusarium oxysporum: Crystal Structures and Substrate Recognition Mechanism.
Chembiochem, 21, 2020
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6EDC
 | | hcGAS-16bp dsDNA complex | | 分子名称: | Cyclic GMP-AMP synthase, DNA (5'-D(*AP*AP*AP*TP*TP*GP*CP*CP*GP*AP*AP*GP*AP*CP*GP*AP*A)-3'), DNA (5'-D(*TP*TP*CP*GP*TP*CP*TP*TP*CP*GP*GP*CP*AP*AP*T)-3'), ... | | 著者 | Xie, W, Lama, L, Adura, C, Glickman, J.F, Tuschl, T, Patel, D.J. | | 登録日 | 2018-08-09 | | 公開日 | 2019-05-29 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.712 Å) | | 主引用文献 | Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation.
Proc.Natl.Acad.Sci.USA, 116, 2019
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8OV0
 | | MUC5AC CysD7 amino acids 3518-3626 | | 分子名称: | CALCIUM ION, CHLORIDE ION, Mucin-5AC | | 著者 | Khmelnitsky, L, Milo, A, Dym, O, Fass, D. | | 登録日 | 2023-04-25 | | 公開日 | 2023-08-16 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Diversity of CysD domains in gel-forming mucins.
Febs J., 290, 2023
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7SD0
 | | Cryo-EM structure of the SHOC2:PP1C:MRAS complex | | 分子名称: | Leucine-rich repeat protein SHOC-2, MAGNESIUM ION, MANGANESE (II) ION, ... | | 著者 | Liau, N.P.D, Johnson, M.C, Hymowitz, S.G, Sudhamsu, J. | | 登録日 | 2021-09-29 | | 公開日 | 2022-04-20 | | 最終更新日 | 2023-11-29 | | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | | 主引用文献 | Structural basis for SHOC2 modulation of RAS signalling.
Nature, 609, 2022
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4WXQ
 | | Crystal Structure of the Myocilin Olfactomedin Domain | | 分子名称: | CALCIUM ION, HEXAETHYLENE GLYCOL, Myocilin, ... | | 著者 | Orwig, S.D, Turnage, K.C, Donegan, R.K, Lieberman, R.L. | | 登録日 | 2014-11-14 | | 公開日 | 2015-04-01 | | 最終更新日 | 2017-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Structural basis for misfolding in myocilin-associated glaucoma.
Hum.Mol.Genet., 24, 2015
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6OFV
 | | F95Q Epi-isozizaene synthase | | 分子名称: | Epi-isozizaene synthase, GLYCEROL, MAGNESIUM ION, ... | | 著者 | Blank, P.N, Christianson, D.W. | | 登録日 | 2019-04-01 | | 公開日 | 2019-06-12 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | | 主引用文献 | Crystal structure of F95Q epi-isozizaene synthase, an engineered sesquiterpene cyclase that generates biofuel precursors beta- and gamma-curcumene.
J.Struct.Biol., 207, 2019
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6ZZB
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8H5D
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5E13
 | | Crystal structure of Eosinophil-derived neurotoxin in complex with the triazole double-headed ribonucleoside 11c | | 分子名称: | 3'-{4-[(4-amino-2-oxopyrimidin-1(2H)-yl)methyl]-1H-1,2,3-triazol-1-yl}-3'-deoxyadenosine, Non-secretory ribonuclease | | 著者 | Chatzileontiadou, D.S.M, Stravodimos, G.A, Kantsadi, A.L, Leonidas, D.D. | | 登録日 | 2015-09-29 | | 公開日 | 2015-11-18 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.34 Å) | | 主引用文献 | Triazole double-headed ribonucleosides as inhibitors of eosinophil derived neurotoxin.
Bioorg.Chem., 63, 2015
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4X1Y
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7SCW
 | | KRAS full length wild-type in complex with RGL1 Ras association domain | | 分子名称: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Isoform 2B of GTPase KRas, MAGNESIUM ION, ... | | 著者 | Eves, B.J, Kuntz, D.A, Ikura, M, Marshall, C.B. | | 登録日 | 2021-09-29 | | 公開日 | 2022-05-18 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | | 主引用文献 | Structures of RGL1 RAS-Association Domain in Complex with KRAS and the Oncogenic G12V Mutant.
J.Mol.Biol., 434, 2022
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6UBF
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6OAY
 | | Structure of the hyperactive ClpB mutant K476C, bound to casein, post-state | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Alpha-S1-casein, Hyperactive disaggregase ClpB, ... | | 著者 | Rizo, A.R, Lin, J.-B, Gates, S.N, Tse, E, Bart, S.M, Castellano, L.M, Dimaio, F, Shorter, J, Southworth, D.R. | | 登録日 | 2019-03-18 | | 公開日 | 2019-06-12 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase.
Nat Commun, 10, 2019
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4X3H
 | | CRYSTAL STRUCTURE OF ARC N-LOBE COMPLEXED WITH STARGAZIN PEPTIDE | | 分子名称: | Activity-regulated cytoskeleton-associated protein, VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-2 SUBUNIT | | 著者 | zhang, W, ward, m, leahy, d, worley, p. | | 登録日 | 2014-11-30 | | 公開日 | 2015-06-03 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.401 Å) | | 主引用文献 | Structural basis of arc binding to synaptic proteins: implications for cognitive disease.
Neuron, 86, 2015
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5HLP
 | | X-RAY CRYSTAL STRUCTURE OF GSK3B IN COMPLEX WITH BRD3937 | | 分子名称: | 4-(2-methoxyphenyl)-3,7,7-trimethyl-1,6,7,8-tetrahydro-5H-pyrazolo[3,4-b]quinolin-5-one, Glycogen synthase kinase-3 beta | | 著者 | White, A, Lakshminarasimhan, D, Nadupalli, A, Suto, R.K. | | 登録日 | 2016-01-15 | | 公開日 | 2016-05-25 | | 最終更新日 | 2016-07-27 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects.
Acs Chem.Biol., 11, 2016
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8SYF
 | | Homology model of Acto-HMM complex in ADP-state. Chicken smooth muscle HMM and chicken pectoralis actin | | 分子名称: | Actin, alpha skeletal muscle, Myosin light polypeptide 6, ... | | 著者 | Hojjatian, A, Taylor, D.W, Daneshparvar, N, Trybus, K.M, Taylor, K.A. | | 登録日 | 2023-05-25 | | 公開日 | 2023-08-30 | | 最終更新日 | 2024-08-07 | | 実験手法 | ELECTRON MICROSCOPY (19 Å) | | 主引用文献 | Double-headed binding of myosin II to F-actin shows the effect of strain on head structure.
J.Struct.Biol., 215, 2023
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6OQ1
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4X3I
 | | The crystal structure of Arc N-lobe complexed with CAMK2A fragment | | 分子名称: | Activity-regulated cytoskeleton-associated protein, CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA | | 著者 | Zhang, W, Ward, M, Leahy, D, Worley, P. | | 登録日 | 2014-11-30 | | 公開日 | 2015-06-03 | | 最終更新日 | 2017-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural basis of arc binding to synaptic proteins: implications for cognitive disease.
Neuron, 86, 2015
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6UFF
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6S35
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7SCX
 | | KRAS full-length G12V in complex with RGL1 Ras association domain | | 分子名称: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Isoform 2B of GTPase KRas, MAGNESIUM ION, ... | | 著者 | Eves, B.J, Kuntz, D.A, Ikura, M, Marshall, C.B. | | 登録日 | 2021-09-29 | | 公開日 | 2022-05-18 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | Structures of RGL1 RAS-Association Domain in Complex with KRAS and the Oncogenic G12V Mutant.
J.Mol.Biol., 434, 2022
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