6WHB
| MEKK1 TOG domain (548-867) | 分子名称: | ACETATE ION, GLYCEROL, Mitogen-activated protein kinase kinase kinase 1 | 著者 | Filipcik, P, Mace, P.D. | 登録日 | 2020-04-07 | 公開日 | 2020-08-26 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.90032053 Å) | 主引用文献 | A cryptic tubulin-binding domain links MEKK1 to curved tubulin protomers. Proc.Natl.Acad.Sci.USA, 117, 2020
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6CWE
| Structure of alpha-GSA[8,6P] bound by CD1d and in complex with the Va14Vb8.2 TCR | 分子名称: | (5R,6S,7S)-5,6-dihydroxy-7-(octanoylamino)-N-(6-phenylhexyl)-8-{[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}octanamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Wang, J, Zajonc, D. | 登録日 | 2018-03-30 | 公開日 | 2019-04-03 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Glycolipid recognition by iNKT cells To Be Published
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5AKF
| THE CRYSTAL STRUCTURE OF I-DMOI Q42AK120M IN COMPLEX WITH ITS TARGET DNA NICKED IN THE CODING STRAND A AND IN THE PRESENCE OF 2MM MN | 分子名称: | 25MER, 5'-D(*GP*CP*CP*TP*TP*GP*CP*CP*GP*GP*GP*TP*AP*AP)-3', 5'-D(*GP*TP*TP*CP*CP*GP*GP*CP*GP*CP*GP)-3', ... | 著者 | Molina, R, Marcaida, M.J, Redondo, P, Marenchino, M, D'Abramo, M, Montoya, G, Prieto, J. | 登録日 | 2015-03-03 | 公開日 | 2015-06-17 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Engineering a Nickase on the Homing Endonuclease I-Dmoi Scaffold. J.Biol.Chem., 290, 2015
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8U30
| TRPV1 in nanodisc bound with diC8-PIP2 in the closed state | 分子名称: | SODIUM ION, Transient receptor potential cation channel subfamily V member 1, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | 著者 | Arnold, W.R, Julius, D, Cheng, Y. | 登録日 | 2023-09-06 | 公開日 | 2024-05-08 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis of TRPV1 modulation by endogenous bioactive lipids. Nat.Struct.Mol.Biol., 2024
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8FCN
| Cryo-EM structure of p97:UBXD1 VIM-only state | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6 | 著者 | Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R. | 登録日 | 2022-12-01 | 公開日 | 2023-06-21 | 最終更新日 | 2023-12-20 | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | 主引用文献 | The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions. Nat.Struct.Mol.Biol., 30, 2023
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8CSY
| Local refinement of cytoplasmic domains of band3-I in class 2 of erythrocyte ankyrin-1 complex | 分子名称: | Band 3 anion transport protein | 著者 | Vallese, F, Kim, K, Yen, L.Y, Johnston, J.D, Noble, A.J, Cali, T, Clarke, O.B. | 登録日 | 2022-05-13 | 公開日 | 2022-07-20 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Architecture of the human erythrocyte ankyrin-1 complex. Nat.Struct.Mol.Biol., 29, 2022
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6VMD
| Chloroplast ATP synthase (C1, CF1) | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase delta chain, ... | 著者 | Yang, J.-H, Williams, D, Kandiah, E, Fromme, P, Chiu, P.-L. | 登録日 | 2020-01-27 | 公開日 | 2020-09-09 | 最終更新日 | 2020-09-16 | 実験手法 | ELECTRON MICROSCOPY (4.53 Å) | 主引用文献 | Structural basis of redox modulation on chloroplast ATP synthase. Commun Biol, 3, 2020
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7OA7
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6VOO
| Chloroplast ATP synthase (R1, CF1) | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase delta chain, ... | 著者 | Yang, J.-H, Williams, D, Kandiah, E, Fromme, P, Chiu, P.-L. | 登録日 | 2020-01-30 | 公開日 | 2020-09-09 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | 主引用文献 | Structural basis of redox modulation on chloroplast ATP synthase. Commun Biol, 3, 2020
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6GRC
| eukaryotic junction-resolving enzyme GEN-1 binding with Sodium | 分子名称: | DNA (5'-D(*TP*AP*CP*CP*CP*AP*CP*CP*AP*CP*CP*GP*CP*TP*CP*A)-3'), DNA (5'-D(*TP*GP*AP*GP*CP*GP*GP*TP*GP*GP*TP*TP*GP*GP*T)-3'), MAGNESIUM ION, ... | 著者 | Lilley, D.M.J, Liu, Y, Freeman, D.J. | 登録日 | 2018-06-11 | 公開日 | 2018-09-26 | 最終更新日 | 2019-02-13 | 実験手法 | X-RAY DIFFRACTION (2.452 Å) | 主引用文献 | A monovalent ion in the DNA binding interface of the eukaryotic junction-resolving enzyme GEN1. Nucleic Acids Res., 46, 2018
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8U2Z
| TRPV1 in nanodisc bound with diC8-PIP2 in the dilated state | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL, SODIUM ION, ... | 著者 | Arnold, W.R, Julius, D, Cheng, Y. | 登録日 | 2023-09-06 | 公開日 | 2024-05-08 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural basis of TRPV1 modulation by endogenous bioactive lipids. Nat.Struct.Mol.Biol., 2024
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6VJJ
| Crystal Structure of wild-type KRAS4b (GMPPNP-bound) in complex with RAS-binding domain (RBD) of RAF1/CRAF | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, CHLORIDE ION, ... | 著者 | Tran, T.H, Dharmaiah, S, Simanshu, D.K. | 登録日 | 2020-01-16 | 公開日 | 2020-11-25 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation. Nat Commun, 12, 2021
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6WNX
| FBXW11-SKP1 in complex with a pSer33/pSer37 Beta-Catenin peptide | 分子名称: | Catenin beta-1, F-box/WD repeat-containing protein 11, GLYCEROL, ... | 著者 | Ivanochko, D, Edwards, A.M, Bountra, C, Arrowsmith, C.H, Boettcher, J, Structural Genomics Consortium (SGC) | 登録日 | 2020-04-23 | 公開日 | 2020-05-06 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | FBXW11-SKP1 in complex with a pSer33/pSer37 Beta-Catenin peptide To Be Published
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6VLM
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6VMG
| Chloroplast ATP synthase (O3, CF1FO) | 分子名称: | ATP synthase delta chain, chloroplastic, ATP synthase epsilon chain, ... | 著者 | Yang, J.-H, Williams, D, Kandiah, E, Fromme, P, Chiu, P.-L. | 登録日 | 2020-01-27 | 公開日 | 2020-09-09 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (6.46 Å) | 主引用文献 | Structural basis of redox modulation on chloroplast ATP synthase. Commun Biol, 3, 2020
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5UQY
| Crystal structure of Marburg virus GP in complex with the human survivor antibody MR78 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ENVELOPE GLYCOPROTEIN GP1, ... | 著者 | Hashiguchi, T, Fusco, M.L, Hastie, K.M, Bomholdt, Z.A, Lee, J.E, Flyak, A.I, Matsuoka, R, Kohda, D, Yanagi, Y, Hammel, M, Crowe, J.E, Saphire, E.O. | 登録日 | 2017-02-08 | 公開日 | 2017-03-01 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Structural basis for Marburg virus neutralization by a cross-reactive human antibody. Cell, 160, 2015
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6Q3Z
| Crystal structure of the first bromodomain of human BRD4 in complex with the inhibitor 16k | 分子名称: | (7~{R})-2-[[2-ethoxy-4-(1-methylpiperidin-4-yl)phenyl]amino]-7-ethyl-5-methyl-8-[(4-methylthiophen-2-yl)methyl]-7~{H}-pteridin-6-one, 1,2-ETHANEDIOL, Bromodomain-containing protein 4 | 著者 | Heidenreich, D, Watts, E, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Knapp, S, Hoelder, S, Structural Genomics Consortium (SGC) | 登録日 | 2018-12-04 | 公開日 | 2019-03-06 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Designing Dual Inhibitors of Anaplastic Lymphoma Kinase (ALK) and Bromodomain-4 (BRD4) by Tuning Kinase Selectivity. J.Med.Chem., 62, 2019
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4Y52
| Crystal structure of 5-Carboxycytosine Recognition by RNA Polymerase II during Transcription Elongation. | 分子名称: | DNA (29-MER), DNA (5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, ... | 著者 | Wang, L, Chong, J, Wang, D. | 登録日 | 2015-02-11 | 公開日 | 2015-07-15 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex. Nature, 523, 2015
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6WQZ
| Structure of human ATG9A, the only transmembrane protein of the core autophagy machinery | 分子名称: | Autophagy-related protein 9A, Lauryl Maltose Neopentyl Glycol | 著者 | Guardia, C.M, Tan, X, Lian, T, Rana, M.S, Zhou, W, Christenson, E.T, Lowry, A.J, Faraldo-Gomez, J.D, Bonifacino, J.S, Jiang, J, Banerjee, A. | 登録日 | 2020-04-29 | 公開日 | 2020-07-08 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structure of Human ATG9A, the Only Transmembrane Protein of the Core Autophagy Machinery. Cell Rep, 31, 2020
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6WA8
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5UTY
| Crystal Structure of a Stabilized DS-SOSIP.mut4 BG505 gp140 HIV-1 Env Trimer, Containing Mutations I201C-P433C (DS), L154M, N300M, N302M, T320L in Complex with Human Antibodies PGT122 and 35O22 at 4.1 Angstrom | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35O22 Fab heavy chain, ... | 著者 | Xu, K, Chuang, G.-Y, Pancera, M, Kwong, P.D. | 登録日 | 2017-02-15 | 公開日 | 2017-03-29 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.412 Å) | 主引用文献 | Structure-Based Design of a Soluble Prefusion-Closed HIV-1 Env Trimer with Reduced CD4 Affinity and Improved Immunogenicity. J. Virol., 91, 2017
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6SWX
| Leishmania major methionyl-tRNA synthetase in complex with an allosteric inhibitor | 分子名称: | METHIONINE, Putative methionyl-tRNA synthetase, methyl 2-[[6-[[3,4-bis(fluoranyl)phenyl]amino]-1-methyl-pyrazolo[3,4-d]pyrimidin-4-yl]amino]ethanoate | 著者 | Robinson, D.A, Torrie, L.S, Shepherd, S.M, De Rycker, M, Thomas, M.G, Wyatt, P.G. | 登録日 | 2019-09-24 | 公開日 | 2020-08-05 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA Synthetase. Acs Infect Dis., 6, 2020
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7ZXA
| Crystal structure of human cathepsin L with covalently bound aloxistatin (E-64D) | 分子名称: | 1,2-ETHANEDIOL, Cathepsin L, DI(HYDROXYETHYL)ETHER, ... | 著者 | Falke, S, Lieske, J, Guenther, S, Reinke, P.Y.A, Ewert, W, Loboda, J, Karnicar, K, Usenik, A, Lindic, N, Sekirnik, A, Chapman, H.N, Hinrichs, W, Turk, D, Meents, A. | 登録日 | 2022-05-20 | 公開日 | 2023-05-31 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structural Elucidation and Antiviral Activity of Covalent Cathepsin L Inhibitors. J.Med.Chem., 67, 2024
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5KAG
| Crystal structure of a dioxygenase in the Crotonase superfamily in P21 | 分子名称: | (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase, OXYGEN MOLECULE, [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-4-HYDROXY-3-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL (3R)-4-({3-[(2-{[(3,5-DIHYDROXYPHENYL)ACETYL]AMINO}ETHYL)AMINO]-3-OXOPROPYL}AMINO)-3-HYDROXY-2,2-DIMETHYL-4-OXOBUTYL DIHYDROGEN DIPHOSPHATE | 著者 | Li, K, Fielding, E.N, Condurso, H.L, Bruner, S.D. | 登録日 | 2016-06-01 | 公開日 | 2017-06-21 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.456 Å) | 主引用文献 | Probing the structural basis of oxygen binding in a cofactor-independent dioxygenase. Acta Crystallogr D Struct Biol, 73, 2017
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7KJN
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