7ZXA

Crystal structure of human cathepsin L with covalently bound aloxistatin (E-64D)

Summary for 7ZXA

• Entry DOI: 10.2210/pdb7zxa/pdb
• Related: 7ZS7 7ZVF
• Descriptor: Cathepsin L, ethyl (3S)-3-hydroxy-4-({(2S)-4-methyl-1-[(3-methylbutyl)amino]-1-oxopentan-2-yl}amino)-4-oxobutanoate, PENTAETHYLENE GLYCOL, ... (10 entities in total)
• Functional Keywords: cystein protease, drug target, lysosome, virus cell entry, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 101084.21

Authors

Falke, S.,Lieske, J.,Guenther, S.,Reinke, P.Y.A.,Ewert, W.,Loboda, J.,Karnicar, K.,Usenik, A.,Lindic, N.,Sekirnik, A.,Chapman, H.N.,Hinrichs, W.,Turk, D.,Meents, A. (deposition date: 2022-05-20, release date: 2023-05-31, Last modification date: 2024-02-07)

• Primary citation: Falke, S.,Lieske, J.,Herrmann, A.,Guenther, S.,Reinke, P.Y.A.,Ewert, W.,Loboda, J.,Karnicar, K.,Usenik, A.,Lindic, N.,Sekirnik, A.,Chapman, H.N.,Hinrichs, W.,Turk, D.,Meents, A.; Structural elucidation of antiviral cathepsin L inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.6 Å)