7ZS7

Crystal structure of human cathepsin L with covalently bound calpain inhibitor VI

Summary for 7ZS7

• Entry DOI: 10.2210/pdb7zs7/pdb
• Descriptor: Cathepsin L, (2S)-2-[(4-fluorophenyl)sulfonylamino]-3-methyl-N-[(2S)-4-methyl-1-oxidanyl-pentan-2-yl]butanamide, DIMETHYL SULFOXIDE, ... (6 entities in total)
• Functional Keywords: cystein protease, drug target, lysosome, virus cell entry, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 99225.19

Authors

Falke, S.,Lieske, J.,Guenther, S.,Reinke, P.Y.A.,Ewert, W.,Loboda, J.,Karnicar, K.,Usenik, A.,Lindic, N.,Sekirnik, A.,Chapman, H.N.,Hinrichs, W.,Turk, D.,Meents, A. (deposition date: 2022-05-06, release date: 2023-05-17, Last modification date: 2024-05-15)

• Primary citation: Falke, S.,Lieske, J.,Herrmann, A.,Loboda, J.,Karnicar, K.,Gunther, S.,Reinke, P.Y.A.,Ewert, W.,Usenik, A.,Lindic, N.,Sekirnik, A.,Dretnik, K.,Tsuge, H.,Turk, V.,Chapman, H.N.,Hinrichs, W.,Ebert, G.,Turk, D.,Meents, A.; Structural Elucidation and Antiviral Activity of Covalent Cathepsin L Inhibitors.; J.Med.Chem., 2024; PubMed: 38630165; DOI: 10.1021/acs.jmedchem.3c02351

Experimental method

X-RAY DIFFRACTION (1.6 Å)