9BKF
 
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8ZX6
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8Y6Z
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9BNQ
 | | N-(4-(isothiocyanatomethyl)phenyl)methanesulfonamide complexed with Macrophage Migration Inhibitory Factor | | 分子名称: | ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, N-{[4-(methanesulfonamido)phenyl]methyl}methanethioamide, ... | | 著者 | Fellner, M, Rutledge, M.T, Putha, L, Kok, L.K, Gamble, A.B, Wilbanks, S.M, Vernall, A.J, Tyndall, J.D.A. | | 登録日 | 2024-05-02 | | 公開日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (1.09 Å) | | 主引用文献 | Covalent isothiocyanate inhibitors of macrophage migration inhibitory factor as potential colorectal cancer treatments.
Chemmedchem, 2024
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6OBV
 | | Structural insights into dehydratase substrate selection for the borrelidin and fluvirucin polyketide synthases | | 分子名称: | fluvirucin B1 DH domain from module 1 | | 著者 | McAndrew, R.P, Barajas, J.F, Pereira, J.H, Keasling, J.D, Adams, P.D. | | 登録日 | 2019-03-21 | | 公開日 | 2019-06-05 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Structural insights into dehydratase substrate selection for the borrelidin and fluvirucin polyketide synthases.
J Ind Microbiol Biotechnol., 46, 2019
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6WEQ
 | | DENV1 NS1 in complex with neutralizing 2B7 Fab fragment | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2B7 Fab fragment heavy chain, 2B7 Fab fragment light chain, ... | | 著者 | Akey, D.L, Smith, J.L. | | 登録日 | 2020-04-02 | | 公開日 | 2020-12-23 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structural basis for antibody inhibition of flavivirus NS1-triggered endothelial dysfunction.
Science, 371, 2021
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8GJM
 | | 17b10 fab in complex with full-length SARS-CoV-2 Spike G614 trimer | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Kwon, H.J, Zhang, J, Kosikova, M, Tang, W.C, Rodriguez, U.O, Peng, H.Q, Meseda, C.A, Pedro, C.L, Schmeisser, F, Lu, J.M, Zhou, B, Davis, C.T, Wentworth, D.E, Chen, W.H, Shriver, M.C, Pasetti, M.F, Weir, J.P, Chen, B, Xie, H. | | 登録日 | 2023-03-16 | | 公開日 | 2023-04-05 | | 最終更新日 | 2023-04-19 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Distinct in vitro and in vivo neutralization profiles of monoclonal antibodies elicited by the receptor binding domain of the ancestral SARS-CoV-2.
J Med Virol, 95, 2023
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8WMC
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8WMI
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8WDF
 | | Chemoreceptor PilJ from Pseudomonas aeruginosa PA14 | | 分子名称: | Chemotaxis chemoreceptor PilJ | | 著者 | Cui, R, Li, D.F. | | 登録日 | 2023-09-15 | | 公開日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (2.996 Å) | | 主引用文献 | The ligand binding domain of a type IV pilus chemoreceptor PilJ has a different fold from that of another PilJ-type receptor McpN.
Biochem.Biophys.Res.Commun., 706, 2024
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9B3P
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9B35
 | | Ligand-binding and transmembrane domains of kainate receptor GluK2 in the open state, a complex with agonist glutamate and positive allosteric modulator BPAM344 | | 分子名称: | GLUTAMIC ACID, Glutamate receptor ionotropic, kainate 2 | | 著者 | Nadezhdin, K.D, Gangwar, S.P, Sobolevsky, A.I. | | 登録日 | 2024-03-18 | | 公開日 | 2024-05-22 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Kainate receptor channel opening and gating mechanism.
Nature, 630, 2024
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8WM4
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8Z9A
 | | Cryo-EM structure of the insect olfactory receptor OR5-Orco heterocomplex from Acyrthosiphon pisum bound with geranyl acetate | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Odorant receptor, ApisOR5, ... | | 著者 | Wang, Y.D, Qiu, L, Guan, Z.Y, Wang, Q, Wang, G.R, Yin, P. | | 登録日 | 2024-04-23 | | 公開日 | 2024-06-19 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural basis for odorant recognition of the insect odorant receptor OR-Orco heterocomplex.
Science, 384, 2024
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8Y7F
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7OWI
 | | Crystal structure of dimeric chlorite dismutase variant R127A (CCld R127A) from Cyanothece sp. PCC7425 | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Chlorite dismutase, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Schmidt, D, Mlynek, G, Djinovic-Carugo, K, Obinger, C. | | 登録日 | 2021-06-18 | | 公開日 | 2021-12-22 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Impact of the dynamics of the catalytic arginine on nitrite and chlorite binding by dimeric chlorite dismutase.
J.Inorg.Biochem., 227, 2021
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9FGP
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8W35
 | | Aca2 from Pectobacterium phage ZF40 bound to RNA | | 分子名称: | Anti-CRISPR associated (Aca) protein, Aca2, IR2 and IR-RBS RNA | | 著者 | Wilkinson, M.E, Birkholz, N, Kimanius, D, Fineran, P.C. | | 登録日 | 2024-02-21 | | 公開日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (2.61 Å) | | 主引用文献 | Phage anti-CRISPR control by an RNA- and DNA-binding helix-turn-helix protein.
Nature, 631, 2024
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8BSE
 | | CRYSTAL STRUCTURE OF SARS-COV-2 RECEPTOR BINDING DOMAIN (RBD) in complex with 1D1 Fab | | 分子名称: | 1D1 FAB HEAVY CHAIN, 1D1 FAB LIGHT CHAIN, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | | 著者 | Welin, M, Kimbung, Y.R, Focht, D, Pisitkun, T. | | 登録日 | 2022-11-25 | | 公開日 | 2023-05-17 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Efficacy of the combination of monoclonal antibodies against the SARS-CoV-2 Beta and Delta variants.
Plos One, 18, 2023
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7OUY
 | | Crystal structure of dimeric chlorite dismutase variant R127A (CCld R127A) from Cyanothece sp. PCC7425 in complex with nitrite | | 分子名称: | Chlorite dismutase, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | 著者 | Schmidt, D, Mlynek, G, Djinovic-Carugo, K, Obinger, C. | | 登録日 | 2021-06-14 | | 公開日 | 2021-12-22 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Impact of the dynamics of the catalytic arginine on nitrite and chlorite binding by dimeric chlorite dismutase.
J.Inorg.Biochem., 227, 2021
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8BSF
 | | CRYSTAL STRUCTURE OF SARS-COV-2 RECEPTOR BINDING DOMAIN (RBD-beta variant) in complex with 3D2 Fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3D2 FAB HEAVY CHAIN, 3D2 FAB LIGHT CHAIN, ... | | 著者 | Welin, M, Kimbung, Y.R, Focht, D, Pisitkun, T. | | 登録日 | 2022-11-25 | | 公開日 | 2023-05-17 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Efficacy of the combination of monoclonal antibodies against the SARS-CoV-2 Beta and Delta variants.
Plos One, 18, 2023
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8Z1E
 | | A homotrimeric GPCR architecture of the human cytomegalovirus (UL78) revealed by cryo-EM | | 分子名称: | Uncharacterized protein UL78 | | 著者 | Chen, Y, Li, Y, Zhou, Q, Cong, Z, Lin, S, Yan, J, Chen, X, Yang, D, Ying, T, Wang, M.-W. | | 登録日 | 2024-04-11 | | 公開日 | 2024-05-15 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | | 主引用文献 | A homotrimeric GPCR architecture of the human cytomegalovirus revealed by cryo-EM.
Cell Discov, 10, 2024
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8WQO
 | | Crystal structure of BRD4-BD1 bound with DI106 | | 分子名称: | (3~{R})-6-[[4-(3,5-dimethyl-1~{H}-pyrazol-4-yl)pyrimidin-2-yl]amino]-1,3-dimethyl-4-propan-2-yl-3~{H}-quinoxalin-2-one, Isoform C of Bromodomain-containing protein 4 | | 著者 | Cao, D, Xiong, B. | | 登録日 | 2023-10-12 | | 公開日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (1.13 Å) | | 主引用文献 | Rational design and evaluation of BET-Aurora A dual-inhibitors for treatment of cancers
To Be Published
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8VMB
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6OJV
 | | Crystal structure of human thymidylate synthase delta(7-29) in complex with dUMP and 2-amino-4-oxo-4,7-dihydro-pyrrolo[2,3-d]pyrimidine-methyl-phenyl-L-glutamic acid | | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, N-{4-[(2-amino-4-hydroxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzoyl}-L-glutamic acid, Thymidylate synthase,Thymidylate synthase | | 著者 | Czyzyk, D.J, Anderson, K.S, Valhondo, M, Jorgensen, W.L. | | 登録日 | 2019-04-12 | | 公開日 | 2019-06-19 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.593 Å) | | 主引用文献 | Understanding the structural basis of species selective, stereospecific inhibition for Cryptosporidium and human thymidylate synthase.
Febs Lett., 593, 2019
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