9B35

Ligand-binding and transmembrane domains of kainate receptor GluK2 in the open state, a complex with agonist glutamate and positive allosteric modulator BPAM344

Summary for 9B35

Entry DOI	10.2210/pdb9b35/pdb
EMDB information	44128
Descriptor	Glutamate receptor ionotropic, kainate 2, GLUTAMIC ACID (2 entities in total)
Functional Keywords	kainate receptor, gluk2, positive allosteric modulator, bpam344, open, glutamate, lbd-tmd, ligand-binding domain, transmembrane domain, membrane protein
Biological source	Rattus norvegicus (Norway rat)
Total number of polymer chains	4
Total formula weight	412494.86
Authors	Nadezhdin, K.D.,Gangwar, S.P.,Sobolevsky, A.I. (deposition date: 2024-03-18, release date: 2024-05-22, Last modification date: 2024-06-05)
Primary citation	Gangwar, S.P.,Yelshanskaya, M.V.,Nadezhdin, K.D.,Yen, L.Y.,Newton, T.P.,Aktolun, M.,Kurnikova, M.G.,Sobolevsky, A.I. Kainate receptor channel opening and gating mechanism. Nature, 2024 Cited by PubMed: 38778115 DOI: 10.1038/s41586-024-07475-0 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.4 Å)

Structure validation