7QOU
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![BU of 7qou by Molmil](/molmil-images/mine/7qou) | A mutant of the nitrile hydratase from Geobacillus pallidus having enhanced thermostability | Descriptor: | CHLORIDE ION, COBALT (II) ION, MAGNESIUM ION, ... | Authors: | Van Wyk, J.C, Cowan, D.A, Danson, M.J, Tsekoa, T.L, Sayed, M.F, Sewell, B.T. | Deposit date: | 2021-12-29 | Release date: | 2023-01-18 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Engineering enhanced thermostability into the Geobacillus pallidus nitrile hydratase. Curr Res Struct Biol, 4, 2022
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7QOV
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![BU of 7qov by Molmil](/molmil-images/mine/7qov) | The wild type nitrile hydratase from Geobacillus pallidus | Descriptor: | CHLORIDE ION, COBALT (III) ION, Nitrile hydratase, ... | Authors: | Van Wyk, J.C, Cowan, D.A, Danson, M.J, Tsekoa, T.L, Sayed, M.F, Sewell, B.T. | Deposit date: | 2021-12-29 | Release date: | 2023-01-18 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Engineering enhanced thermostability into the Geobacillus pallidus nitrile hydratase. Curr Res Struct Biol, 4, 2022
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6N8C
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![BU of 6n8c by Molmil](/molmil-images/mine/6n8c) | Structure of the Huntingtin tetramer/dimer mixture determined by paramagnetic NMR | Descriptor: | Huntingtin | Authors: | Schwieters, C.D, Kotler, S.A, Schmidt, T, Ceccon, A, Ghirlando, R, Libich, D.S, Clore, G.M. | Deposit date: | 2018-11-29 | Release date: | 2019-02-13 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Probing initial transient oligomerization events facilitating Huntingtin fibril nucleation at atomic resolution by relaxation-based NMR. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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8D9A
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![BU of 8d9a by Molmil](/molmil-images/mine/8d9a) | Crystal Structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with fluorinated inhibitor 8 | Descriptor: | 2,3,5-trifluoro-N-hydroxybenzamide, Hdac6 protein, POTASSIUM ION, ... | Authors: | Watson, P.R, Christianson, D.W. | Deposit date: | 2022-06-09 | Release date: | 2022-09-28 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Aromatic Ring Fluorination Patterns Modulate Inhibitory Potency of Fluorophenylhydroxamates Complexed with Histone Deacetylase 6. Biochemistry, 61, 2022
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7QOY
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![BU of 7qoy by Molmil](/molmil-images/mine/7qoy) | A mutant of the nitrile hydratase from Geobacillus pallidus having enhanced thermostability | Descriptor: | CHLORIDE ION, COBALT (III) ION, Nitrile hydratase, ... | Authors: | Van Wyk, J.C, Cowan, D.A, Danson, M.J, Tsekoa, T.L, Sayed, M.F, Sewell, B.T. | Deposit date: | 2021-12-29 | Release date: | 2023-01-18 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | A mutant of the nitrile hydratase from Geobacillus pallidus having enhanced thermostability To be published
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5FMV
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![BU of 5fmv by Molmil](/molmil-images/mine/5fmv) | Crystal structure of human CD45 extracellular region, domains d1-d4 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C, SULFATE ION | Authors: | Chang, V.T, Fernandes, R.A, Ganzinger, K.A, Lee, S.F, Siebold, C, McColl, J, Jonsson, P, Palayret, M, Harlos, K, Coles, C.H, Jones, E.Y, Lui, Y, Huang, E, Gilbert, R.J.C, Klenerman, D, Aricescu, A.R, Davis, S.J. | Deposit date: | 2015-11-09 | Release date: | 2016-03-23 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Initiation of T Cell Signaling by Cd45 Segregation at 'Close Contacts'. Nat.Immunol., 17, 2016
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8U3L
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![BU of 8u3l by Molmil](/molmil-images/mine/8u3l) | |
4WXS
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![BU of 4wxs by Molmil](/molmil-images/mine/4wxs) | Crystal Structure of the E396D SNP Variant of the Myocilin Olfactomedin Domain | Descriptor: | CALCIUM ION, GLYCEROL, HEXAETHYLENE GLYCOL, ... | Authors: | Donegan, R.K, Freeman, D.M, Lieberman, R.L. | Deposit date: | 2014-11-14 | Release date: | 2015-04-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for misfolding in myocilin-associated glaucoma. Hum.Mol.Genet., 24, 2015
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5FN6
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![BU of 5fn6 by Molmil](/molmil-images/mine/5fn6) | Crystal structure of human CD45 extracellular region, domains d1-d3 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C | Authors: | Chang, V.T, Fernandes, R.A, Ganzinger, K.A, Lee, S.F, Siebold, C, McColl, J, Jonsson, P, Palayret, M, Harlos, K, Coles, C.H, Jones, E.Y, Lui, Y, Huang, E, Gilbert, R.J.C, Klenerman, D, Aricescu, A.R, Davis, S.J. | Deposit date: | 2015-11-10 | Release date: | 2016-03-23 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Initiation of T Cell Signaling by Cd45 Segregation at 'Close Contacts'. Nat.Immunol., 17, 2016
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8D09
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![BU of 8d09 by Molmil](/molmil-images/mine/8d09) | Hallucinated C4 protein assembly HALC4_136 | Descriptor: | HALC4_136 | Authors: | Ragotte, R.J, Bera, A.K, Wicky, B.I.M, Milles, L.F, Baker, D. | Deposit date: | 2022-05-25 | Release date: | 2022-09-28 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Hallucinating symmetric protein assemblies. Science, 378, 2022
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8D06
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![BU of 8d06 by Molmil](/molmil-images/mine/8d06) | Hallucinated C3 protein assembly HALC3_104 | Descriptor: | HALC3_104 | Authors: | Ragotte, R.J, Bera, A.K, Wicky, B.I.M, Milles, L.F, Baker, D. | Deposit date: | 2022-05-25 | Release date: | 2022-09-28 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Hallucinating symmetric protein assemblies. Science, 378, 2022
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8D98
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![BU of 8d98 by Molmil](/molmil-images/mine/8d98) | |
6VLM
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![BU of 6vlm by Molmil](/molmil-images/mine/6vlm) | |
8Q9I
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![BU of 8q9i by Molmil](/molmil-images/mine/8q9i) | |
8CTB
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![BU of 8ctb by Molmil](/molmil-images/mine/8ctb) | Human PRMT5:MEP50 structure with Fragment 3 and MTA Bound | Descriptor: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, 7-chloro-1-methyl-1H-benzimidazol-2-amine, Methylosome protein 50, ... | Authors: | Gunn, R.J, Lawson, J.D, Smith, C.R. | Deposit date: | 2022-05-13 | Release date: | 2022-10-05 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. Rsc Med Chem, 13, 2022
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8U3J
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8QCR
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![BU of 8qcr by Molmil](/molmil-images/mine/8qcr) | |
7LKH
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![BU of 7lkh by Molmil](/molmil-images/mine/7lkh) | Chicken Scap D435V L1-L7 domain / Fab complex focused map | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4G10 Fab heavy chain, 4G10 Fab kappa chain, ... | Authors: | Kober, D.L, Radhakrishnan, A, Goldstein, J.L, Brown, M.S, Clark, L.D, Bai, X.-C, Rosenbaum, D.M. | Deposit date: | 2021-02-02 | Release date: | 2021-06-30 | Last modified: | 2021-07-28 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Scap structures highlight key role for rotation of intertwined luminal loops in cholesterol sensing. Cell, 184, 2021
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4WX4
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![BU of 4wx4 by Molmil](/molmil-images/mine/4wx4) | Crystal structure of adenovirus 8 protease in complex with a nitrile inhibitor | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCINE, N-[(2-cyanopyrimidin-4-yl)methyl]-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-methoxybenzamide, ... | Authors: | Grosche, P, Sirockin, F, Mac Sweeney, A, Ramage, P, Erbel, P, Melkko, S, Bernardi, A, Hughes, N, Ellis, D, Combrink, K, Jarousse, N, Altmann, E. | Deposit date: | 2014-11-13 | Release date: | 2015-01-14 | Last modified: | 2015-01-28 | Method: | X-RAY DIFFRACTION (1.03 Å) | Cite: | Structure-based design and optimization of potent inhibitors of the adenoviral protease. Bioorg.Med.Chem.Lett., 25, 2015
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7LFM
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![BU of 7lfm by Molmil](/molmil-images/mine/7lfm) | MODEL OF MHC CLASS Ib H2-M3 WITH MOUSE ND1 N-TERMINAL HEPTAPEPTIDE, VAL MUTANT, TRICLINIC CELL, REFINED AT 1.60 ANGSTROMS RESOLUTION | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, Heptapeptide from NADH-ubiquinone oxidoreductase chain 1, ... | Authors: | Tomchick, D.R, Deisenhofer, J, Shen, S. | Deposit date: | 2021-01-17 | Release date: | 2021-07-14 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure and dynamics of major histocompatibility class Ib molecule H2-M3 complexed with mitochondrial-derived peptides. J.Biomol.Struct.Dyn., 40, 2022
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7TT7
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![BU of 7tt7 by Molmil](/molmil-images/mine/7tt7) | BamABCDE bound to substrate EspP in the barrelized EspP/continuous open BamA state | Descriptor: | Maltose/maltodextrin-binding periplasmic protein,Serine protease EspP chimera, Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamC, ... | Authors: | Doyle, M.T, Jimah, J.R, Dowdy, T, Ohlemacher, S.I, Larion, M, Hinshaw, J.E, Bernstein, H.D. | Deposit date: | 2022-01-31 | Release date: | 2022-03-30 | Last modified: | 2022-04-13 | Method: | ELECTRON MICROSCOPY (4.8 Å) | Cite: | Cryo-EM structures reveal multiple stages of bacterial outer membrane protein folding. Cell, 185, 2022
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7LFK
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![BU of 7lfk by Molmil](/molmil-images/mine/7lfk) | MODEL OF MHC CLASS Ib H2-M3 WITH MOUSE ND1 N-TERMINAL HEPTAPEPTIDE, THR MUTANT, REFINED AT 1.60 ANGSTROMS RESOLUTION | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, Heptapeptide from NADH-ubiquinone oxidoreductase chain 1, ... | Authors: | Tomchick, D.R, Deisenhofer, J, Shen, S. | Deposit date: | 2021-01-17 | Release date: | 2021-07-14 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure and dynamics of major histocompatibility class Ib molecule H2-M3 complexed with mitochondrial-derived peptides. J.Biomol.Struct.Dyn., 40, 2022
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7TT6
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![BU of 7tt6 by Molmil](/molmil-images/mine/7tt6) | BamABCDE bound to substrate EspP in the intermediate-open EspP state | Descriptor: | Maltose/maltodextrin-binding periplasmic protein,Serine protease EspP chimera, Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamC, ... | Authors: | Doyle, M.T, Jimah, J.R, Dowdy, T, Ohlemacher, S.I, Larion, M, Hinshaw, J.E, Bernstein, H.D. | Deposit date: | 2022-01-31 | Release date: | 2022-03-30 | Last modified: | 2022-04-13 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Cryo-EM structures reveal multiple stages of bacterial outer membrane protein folding. Cell, 185, 2022
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6HJR
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![BU of 6hjr by Molmil](/molmil-images/mine/6hjr) | |
4WZP
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![BU of 4wzp by Molmil](/molmil-images/mine/4wzp) | Ser65 phosphorylated ubiquitin, major conformation | Descriptor: | SULFATE ION, ubiquitin | Authors: | Wauer, T, Wagstaff, J, Freund, S.M.V, Komander, D. | Deposit date: | 2014-11-20 | Release date: | 2015-01-14 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis. Embo J., 34, 2015
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