4WX4
Crystal structure of adenovirus 8 protease in complex with a nitrile inhibitor
Summary for 4WX4
Entry DOI | 10.2210/pdb4wx4/pdb |
Descriptor | Protease, peptide, N-[(2-cyanopyrimidin-4-yl)methyl]-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-methoxybenzamide, ... (6 entities in total) |
Functional Keywords | cysteine protease, inhibitor, cofactor, hydrolase |
Biological source | Human adenovirus D serotype 8 (HAdV-8) More |
Total number of polymer chains | 2 |
Total formula weight | 25234.87 |
Authors | Grosche, P.,Sirockin, F.,Mac Sweeney, A.,Ramage, P.,Erbel, P.,Melkko, S.,Bernardi, A.,Hughes, N.,Ellis, D.,Combrink, K.,Jarousse, N.,Altmann, E. (deposition date: 2014-11-13, release date: 2015-01-14, Last modification date: 2015-01-28) |
Primary citation | Grosche, P.,Sirockin, F.,Mac Sweeney, A.,Ramage, P.,Erbel, P.,Melkko, S.,Bernardi, A.,Hughes, N.,Ellis, D.,Combrink, K.D.,Jarousse, N.,Altmann, E. Structure-based design and optimization of potent inhibitors of the adenoviral protease. Bioorg.Med.Chem.Lett., 25:438-443, 2015 Cited by PubMed: 25571794DOI: 10.1016/j.bmcl.2014.12.057 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.03 Å) |
Structure validation
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