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4WXS

Crystal Structure of the E396D SNP Variant of the Myocilin Olfactomedin Domain

Summary for 4WXS
Entry DOI10.2210/pdb4wxs/pdb
Related4WXQ 4wxu
DescriptorMyocilin, CALCIUM ION, GLYCEROL, ... (7 entities in total)
Functional Keywordsbeta propeller, 5 bladed propeller, olfactomedin, protein binding
Biological sourceHomo sapiens (Human)
Cellular locationSecreted. Myocilin, C-terminal fragment: Secreted. Myocilin, N-terminal fragment: Endoplasmic reticulum: Q99972
Total number of polymer chains1
Total formula weight31998.86
Authors
Donegan, R.K.,Freeman, D.M.,Lieberman, R.L. (deposition date: 2014-11-14, release date: 2015-04-01)
Primary citationDonegan, R.K.,Hill, S.E.,Freeman, D.M.,Nguyen, E.,Orwig, S.D.,Turnage, K.C.,Lieberman, R.L.
Structural basis for misfolding in myocilin-associated glaucoma.
Hum.Mol.Genet., 24:2111-2124, 2015
Cited by
PubMed: 25524706
DOI: 10.1093/hmg/ddu730
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

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