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PDB: 15 件
8W2R
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BU of 8w2r by Molmil
HIV-1 P5-IN intasome core
分子名称: (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, DNA (5'-D(*AP*CP*TP*GP*CP*TP*AP*GP*AP*GP*AP*TP*TP*TP*TP*CP*CP*CP*G)-3'), DNA (5'-D(P*CP*GP*GP*GP*AP*AP*AP*AP*TP*CP*TP*CP*TP*AP*GP*CP*A)-3'), ...
著者Li, M, Craigie, R.
登録日2024-02-21
公開日2024-04-17
最終更新日2024-04-24
実験手法ELECTRON MICROSCOPY (3.23 Å)
主引用文献HIV-1 Integrase Assembles Multiple Species of Stable Synaptic Complex Intasomes That Are Active for Concerted DNA Integration In vitro.
J.Mol.Biol., 436, 2024
8W34
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HIV-1 intasome core assembled with wild-type integrase, 1F
分子名称: (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, DNA (5'-D(*AP*CP*TP*GP*CP*TP*AP*GP*AP*GP*AP*TP*TP*TP*TP*CP*CP*AP*C)-3'), DNA (5'-D(P*GP*TP*GP*GP*AP*AP*AP*AP*TP*CP*TP*CP*TP*AP*GP*CP*A)-3'), ...
著者Li, M, Craigie, R.
登録日2024-02-21
公開日2024-04-17
最終更新日2024-04-24
実験手法ELECTRON MICROSCOPY (2.83 Å)
主引用文献HIV-1 Integrase Assembles Multiple Species of Stable Synaptic Complex Intasomes That Are Active for Concerted DNA Integration In vitro.
J.Mol.Biol., 436, 2024
8W09
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BU of 8w09 by Molmil
HIV-1 wild-type intasome core
分子名称: (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, Integrase, MAGNESIUM ION, ...
著者Li, M, Craigie, R.
登録日2024-02-13
公開日2024-04-17
最終更新日2024-04-24
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献HIV-1 Integrase Assembles Multiple Species of Stable Synaptic Complex Intasomes That Are Active for Concerted DNA Integration In vitro.
J.Mol.Biol., 436, 2024
2BZF
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BU of 2bzf by Molmil
Structural basis for DNA bridging by barrier-to-autointegration factor (BAF)
分子名称: 5'-D(*CP*CP*TP*CP*CP*AP*CP)-3', 5'-D(*GP*TP*GP*GP*AP*GP*GP)-3', BARRIER-TO-AUTOINTEGRATION FACTOR
著者Bradley, C.M, Ronning, D.R, Ghirlando, R, Craigie, R, Dyda, F.
登録日2005-08-16
公開日2005-09-15
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.87 Å)
主引用文献Structural Basis for DNA Bridging by Barrier-to-Autointegration Factor.
Nat.Struct.Mol.Biol., 12, 2005
1K6Y
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BU of 1k6y by Molmil
Crystal Structure of a Two-Domain Fragment of HIV-1 Integrase
分子名称: Integrase, PHOSPHATE ION, POTASSIUM ION, ...
著者Wang, J, Ling, H, Yang, W, Craigie, R.
登録日2001-10-17
公開日2001-12-21
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein.
EMBO J., 20, 2001
4BAC
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BU of 4bac by Molmil
prototype foamy virus strand transfer complexes on product DNA
分子名称: 5'-D(*AP*GP*GP*AP*GP*CP*CP*AP*AP*GP*AP*CP*GP*GP *AP*TP*CP)-3', 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP *TP*TP*GP*TP*AP)-3', DNA (38-MER), ...
著者Yin, Z, Lapkouski, M, Yang, W, Craigie, R.
登録日2012-09-12
公開日2012-10-10
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3.263 Å)
主引用文献Assembly of Prototype Foamy Virus Strand Transfer Complexes on Product DNA Bypassing Catalysis of Integration.
Protein Sci., 21, 2012
1QS4
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BU of 1qs4 by Molmil
Core domain of HIV-1 integrase complexed with Mg++ and 1-(5-chloroindol-3-yl)-3-hydroxy-3-(2H-tetrazol-5-yl)-propenone
分子名称: 1-(5-CHLOROINDOL-3-YL)-3-HYDROXY-3-(2H-TETRAZOL-5-YL)-PROPENONE, MAGNESIUM ION, PROTEIN (HIV-1 INTEGRASE (E.C.2.7.7.49))
著者Goldgur, Y, Craigie, R, Fujiwara, T, Yoshinaga, T, Davies, D.R.
登録日1999-06-25
公開日1999-11-17
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: a platform for antiviral drug design.
Proc.Natl.Acad.Sci.USA, 96, 1999
6U8Q
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BU of 6u8q by Molmil
CryoEM structure of HIV-1 cleaved synaptic complex (CSC) intasome
分子名称: (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, DNA (25-MER), DNA (27-MER), ...
著者Li, M, Chen, X, Craigie, R.
登録日2019-09-05
公開日2020-02-05
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (4.67 Å)
主引用文献A Peptide Derived from Lens Epithelium-Derived Growth Factor Stimulates HIV-1 DNA Integration and Facilitates Intasome Structural Studies.
J.Mol.Biol., 432, 2020
6VDK
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BU of 6vdk by Molmil
CryoEM structure of HIV-1 conserved Intasome Core
分子名称: (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, DNA (25-MER), DNA (27-MER), ...
著者Li, M, Chen, X, Craigie, R.
登録日2019-12-27
公開日2020-02-05
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (4.5 Å)
主引用文献A Peptide Derived from Lens Epithelium-Derived Growth Factor Stimulates HIV-1 DNA Integration and Facilitates Intasome Structural Studies.
J.Mol.Biol., 432, 2020
1CI4
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BU of 1ci4 by Molmil
THE CRYSTAL STRUCTURE OF HUMAN BARRIER-TO-AUTOINTEGRATION FACTOR (BAF)
分子名称: PROTEIN (BARRIER-TO-AUTOINTEGRATION FACTOR (BAF))
著者Umland, T.C, Wei, S.-Q, Craigie, R, Davies, D.R.
登録日1999-04-07
公開日2000-08-16
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural basis of DNA bridging by barrier-to-autointegration factor.
Biochemistry, 39, 2000
2V0X
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BU of 2v0x by Molmil
The dimerization domain of LAP2alpha
分子名称: LAMINA-ASSOCIATED POLYPEPTIDE 2 ISOFORMS ALPHA/ZETA
著者Bradley, C.M, Jones, S, Huang, Y, Suzuki, Y, Kvaratskhelia, M, Hickman, A.B, Craigie, R, Dyda, F.
登録日2007-05-20
公開日2007-06-26
最終更新日2019-05-15
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural Basis for Dimerization of Lap2Alpha, a Component of the Nuclear Lamina.
Structure, 15, 2007
1ITG
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BU of 1itg by Molmil
CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HIV-1 INTEGRASE: SIMILARITY TO OTHER POLYNUCLEOTIDYL TRANSFERASES
分子名称: CACODYLATE ION, HIV-1 INTEGRASE
著者Dyda, F, Hickman, A.B, Jenkins, T.M, Engelman, A, Craigie, R, Davies, D.R.
登録日1994-11-21
公開日1995-05-08
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases.
Science, 266, 1994
1BIS
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BU of 1bis by Molmil
HIV-1 INTEGRASE CORE DOMAIN
分子名称: HIV-1 INTEGRASE
著者Goldgur, Y, Dyda, F, Hickman, A.B, Jenkins, T.M, Craigie, R, Davies, D.R.
登録日1998-06-19
公開日1998-08-19
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Three new structures of the core domain of HIV-1 integrase: an active site that binds magnesium.
Proc.Natl.Acad.Sci.USA, 95, 1998
1BIZ
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BU of 1biz by Molmil
HIV-1 INTEGRASE CORE DOMAIN
分子名称: CACODYLATE ION, HIV-1 INTEGRASE
著者Goldgur, Y, Dyda, F, Hickman, A.B, Jenkins, T.M, Craigie, R, Davies, D.R.
登録日1998-06-21
公開日1998-08-19
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Three new structures of the core domain of HIV-1 integrase: an active site that binds magnesium.
Proc.Natl.Acad.Sci.USA, 95, 1998
1BIU
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BU of 1biu by Molmil
HIV-1 INTEGRASE CORE DOMAIN COMPLEXED WITH MG++
分子名称: HIV-1 INTEGRASE, MAGNESIUM ION
著者Goldgur, Y, Dyda, F, Hickman, A.B, Jenkins, T.M, Craigie, R, Davies, D.R.
登録日1998-06-19
公開日1998-08-19
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Three new structures of the core domain of HIV-1 integrase: an active site that binds magnesium.
Proc.Natl.Acad.Sci.USA, 95, 1998

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