1QS4
Core domain of HIV-1 integrase complexed with Mg++ and 1-(5-chloroindol-3-yl)-3-hydroxy-3-(2H-tetrazol-5-yl)-propenone
Summary for 1QS4
Entry DOI | 10.2210/pdb1qs4/pdb |
Descriptor | PROTEIN (HIV-1 INTEGRASE (E.C.2.7.7.49)), MAGNESIUM ION, 1-(5-CHLOROINDOL-3-YL)-3-HYDROXY-3-(2H-TETRAZOL-5-YL)-PROPENONE, ... (4 entities in total) |
Functional Keywords | dna integration, integrase, hiv, aspartyl protease, endonuclease, transferase |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 3 |
Total formula weight | 50802.25 |
Authors | Goldgur, Y.,Craigie, R.,Fujiwara, T.,Yoshinaga, T.,Davies, D.R. (deposition date: 1999-06-25, release date: 1999-11-17, Last modification date: 2024-02-14) |
Primary citation | Goldgur, Y.,Craigie, R.,Cohen, G.H.,Fujiwara, T.,Yoshinaga, T.,Fujishita, T.,Sugimoto, H.,Endo, T.,Murai, H.,Davies, D.R. Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: a platform for antiviral drug design. Proc.Natl.Acad.Sci.USA, 96:13040-13043, 1999 Cited by PubMed: 10557269DOI: 10.1073/pnas.96.23.13040 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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