1QS4
Core domain of HIV-1 integrase complexed with Mg++ and 1-(5-chloroindol-3-yl)-3-hydroxy-3-(2H-tetrazol-5-yl)-propenone
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | PROTEIN (HIV-1 INTEGRASE (E.C.2.7.7.49)) | polymer | 154 | 16813.2 | 3 | UniProt (Q76353) Pfam (PF00665) UniProt (by SIFTS) (P12497) | Human immunodeficiency virus 1 | |
| 2 | D, F, G (A, B, C) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 3 | E (A) | 1-(5-CHLOROINDOL-3-YL)-3-HYDROXY-3-(2H-TETRAZOL-5-YL)-PROPENONE | non-polymer | 289.7 | 1 | Chemie (100) | |||
| 4 | H, I, J (A, B, C) | water | water | 18.0 | 544 | Chemie (HOH) |
Sequence modifications
A, B, C: 56 - 209 (UniProt: Q76353)
| PDB | External Database | Details |
|---|---|---|
| Glu 131 | Trp 846 | engineered mutation |
| Gly 133 | Ala 848 | conflict |
| Lys 185 | Phe 890 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 50439.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 362.6 | |
| All* | Total formula weight | 50802.2 |
