8W34

HIV-1 intasome core assembled with wild-type integrase, 1F

Summary for 8W34

• Entry DOI: 10.2210/pdb8w34/pdb
• Related: 8W09 8W2R
• EMDB information: 43761
• Descriptor: Integrase, DNA (5'-D(*AP*CP*TP*GP*CP*TP*AP*GP*AP*GP*AP*TP*TP*TP*TP*CP*CP*AP*C)-3'), DNA (5'-D(P*GP*TP*GP*GP*AP*AP*AP*AP*TP*CP*TP*CP*TP*AP*GP*CP*A)-3'), ... (6 entities in total)
• Functional Keywords: hiv-1, integrase, nucleoprotein complexes, insti, intasome, cryoem, viral protein
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 12
• Total formula weight: 330516.87

Authors

Li, M.,Craigie, R. (deposition date: 2024-02-21, release date: 2024-04-17, Last modification date: 2024-04-24)

• Primary citation: Li, M.,Yang, R.,Chen, X.,Wang, H.,Ghirlando, R.,Dimitriadis, E.K.,Craigie, R.; HIV-1 Integrase Assembles Multiple Species of Stable Synaptic Complex Intasomes That Are Active for Concerted DNA Integration In vitro.; J.Mol.Biol., 436:168557-168557, 2024; PubMed: 38582148; DOI: 10.1016/j.jmb.2024.168557

Experimental method

ELECTRON MICROSCOPY (2.83 Å)