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PDB: 22 件
6CDS
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BU of 6cds by Molmil
Human neurofibromin 2/merlin/schwannomin residues 1-339 in complex with PIP2
分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, Merlin, ...
著者Chinthalapudi, K, Sharff, A.J, Bricogne, G, Izard, T.
登録日2018-02-09
公開日2018-07-18
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.62 Å)
主引用文献Lipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2.
Nat Commun, 9, 2018
5I4E
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BU of 5i4e by Molmil
Crystal Structure of Human Nonmuscle Myosin 2C motor domain
分子名称: ADP ORTHOVANADATE, MAGNESIUM ION, Myosin-14,Alpha-actinin A
著者Chinthalapudi, K, Heissler, S.M, Preller, M, Sellers, J.R, Manstein, D.J.
登録日2016-02-11
公開日2017-09-13
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Mechanistic insights into the active site and allosteric communication pathways in human nonmuscle myosin-2C.
Elife, 6, 2017
4AE3
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BU of 4ae3 by Molmil
Crystal structure of ammosamide 272:myosin-2 motor domain complex
分子名称: 1,2-ETHANEDIOL, ADP ORTHOVANADATE, AMMOSAMIDE 272, ...
著者Chinthalapudi, K, Heissler, S.M, Fenical, W, Manstein, D.J.
登録日2012-01-05
公開日2013-01-16
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural Basis for Ammosamide Mediated Myosin Motor Activity Inhibition
To be Published
2PQM
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BU of 2pqm by Molmil
Crystal structure of Cysteine Synthase (OASS) from Entamoeba histolytica at 1.86 A resolution
分子名称: Cysteine synthase, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION
著者Chinthalapudi, K, Alam, N, Gourinath, S.
登録日2007-05-02
公開日2008-04-15
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Crystal structure of native O-acetyl-serine sulfhydrylase from Entamoeba histolytica and its complex with cysteine: structural evidence for cysteine binding and lack of interactions with serine acetyl transferase.
Proteins, 72, 2008
4PR9
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BU of 4pr9 by Molmil
Human Vinculin (residues 891-1066) in complex with PIP
分子名称: GLYCEROL, Vinculin, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
著者Chinthalapudi, K, Rangarajan, E.S, Patil, D, Izard, T.
登録日2014-03-05
公開日2014-12-10
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Mechanism and function of lipid-directed oligomerization of vinculin
To be Published
2XEL
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BU of 2xel by Molmil
Molecular Mechanism of Pentachloropseudilin Mediated Inhibition of Myosin Motor Activity
分子名称: 2,4-DICHLORO-6-(3,4,5-TRICHLORO-1H-PYRROL-2YL)PHENOL, ADP METAVANADATE, MAGNESIUM ION, ...
著者Chinthalapudi, K, Taft, M.H, Martin, R, Hartmann, F.K, Heissler, S.M, Tsiavaliaris, G, Gutzeit, H.O, Knoelker, H.J, Coluccio, L.M, Fedorov, R, Manstein, D.J.
登録日2010-05-16
公開日2011-06-15
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Mechanism and Specificity of Pentachloropseudilin-Mediated Inhibition of Myosin Motor Activity.
J.Biol.Chem., 286, 2011
5L0C
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BU of 5l0c by Molmil
Human metavinculin (residues 959-1134) in complex with PIP2
分子名称: PHOSPHATE ION, Vinculin, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
著者Chinthalapudi, K, Izard, T.
登録日2016-07-27
公開日2016-08-31
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization.
Proc.Natl.Acad.Sci.USA, 113, 2016
5L0F
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BU of 5l0f by Molmil
Human metavinculin quadruple mutant (residues 959-1134)
分子名称: GLYCEROL, Vinculin
著者Chinthalapudi, K, Izard, T.
登録日2016-07-27
公開日2016-08-31
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.76 Å)
主引用文献Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization.
Proc.Natl.Acad.Sci.USA, 113, 2016
5L0G
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BU of 5l0g by Molmil
Human metavinculin MVt Q971R, R975D, T978R mutant (residues 959-1134) in complex with PIP2
分子名称: Vinculin, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
著者Chinthalapudi, K, Izard, T.
登録日2016-07-27
公開日2016-08-31
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization.
Proc.Natl.Acad.Sci.USA, 113, 2016
5L0D
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BU of 5l0d by Molmil
Human Metavinculin(residues 959-1130) in complex with PIP2
分子名称: Vinculin, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
著者Chinthalapudi, K, Izard, T.
登録日2016-07-27
公開日2016-08-31
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization.
Proc.Natl.Acad.Sci.USA, 113, 2016
5L0H
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BU of 5l0h by Molmil
Human metavinculin MVt cardiomyopathy-associated mutant R975W (residues 959-1134) in complex with PIP2
分子名称: DI(HYDROXYETHYL)ETHER, PHOSPHATE ION, Vinculin, ...
著者Chinthalapudi, K, Izard, T.
登録日2016-07-27
公開日2016-08-31
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization.
Proc.Natl.Acad.Sci.USA, 113, 2016
5L0I
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BU of 5l0i by Molmil
Human metavinculin MVt R975W cardiomyopathy-associated mutant (residues 959-1134)
分子名称: GLYCEROL, SODIUM ION, Vinculin
著者Chinthalapudi, K, Izard, T.
登録日2016-07-27
公開日2016-08-31
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization.
Proc.Natl.Acad.Sci.USA, 113, 2016
5L0J
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BU of 5l0j by Molmil
Human vinculin R903Q, D907R, R910T mutant(residues 891-1066)
分子名称: Vinculin
著者Chinthalapudi, K, Izard, T.
登録日2016-07-27
公開日2016-08-31
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (4 Å)
主引用文献Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization.
Proc.Natl.Acad.Sci.USA, 113, 2016
6U4K
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BU of 6u4k by Molmil
Human talin2 residues 1-403
分子名称: Talin-2
著者Izard, T, Rangarajan, E.S, Colgan, L, Yasuda, R, Chinthalapudi, K.
登録日2019-08-26
公開日2020-07-08
最終更新日2020-09-23
実験手法X-RAY DIFFRACTION (2.555 Å)
主引用文献A distinct talin2 structure directs isoform specificity in cell adhesion.
J.Biol.Chem., 295, 2020
7MF3
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BU of 7mf3 by Molmil
Structure of the autoinhibited state of smooth muscle myosin-2
分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Myosin light polypeptide 6, ...
著者Heissler, S.M, Arora, A.S, Billington, N, Sellers, J.R, Chinthalapudi, K.
登録日2021-04-08
公開日2022-01-05
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Cryo-EM structure of the autoinhibited state of myosin-2.
Sci Adv, 7, 2021
6MFS
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BU of 6mfs by Molmil
Mouse talin1 residues 1-138 fused to residues 169-400 in complex with phosphatidylinositol 4,5-bisphosphate (PIP2)
分子名称: PHOSPHATE ION, Talin-1 fusion, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
著者Izard, T, Chinthalapudi, K, Rangarajan, E.S.
登録日2018-09-12
公開日2018-09-26
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献The interaction of talin with the cell membrane is essential for integrin activation and focal adhesion formation.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
8COG
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BU of 8cog by Molmil
Human arginylated beta-actin
分子名称: ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ...
著者Pinto, C.S, Bakker, S.E, Suchenko, A, Hussain, H, Hatano, T, Sampath, K, Chinthalapudi, K, Mishima, M, Balasubramanian, M.
登録日2023-02-28
公開日2024-03-06
実験手法ELECTRON MICROSCOPY (3.499 Å)
主引用文献Structure and physiological investigation of human arginylated beta-actin
To Be Published
8DMY
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BU of 8dmy by Molmil
Cryo-EM structure of cardiac muscle alpha-actin
分子名称: ADENOSINE-5'-DIPHOSPHATE, Actin, alpha cardiac muscle 1, ...
著者Arora, A.S, Huang, H.L, Heissler, S.M, Chinthalapudi, K.
登録日2022-07-09
公開日2023-04-12
実験手法ELECTRON MICROSCOPY (3.07 Å)
主引用文献Structural insights into actin isoforms.
Elife, 12, 2023
8DNF
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BU of 8dnf by Molmil
Cryo-EM structure of nonmuscle gamma-actin
分子名称: ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 2, ...
著者Arora, A.S, Huang, H.L, Heissler, S.M, Chinthalapudi, K.
登録日2022-07-11
公開日2023-04-12
実験手法ELECTRON MICROSCOPY (3.38 Å)
主引用文献Structural insights into actin isoforms.
Elife, 12, 2023
8DMX
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BU of 8dmx by Molmil
Cryo-EM structure of skeletal muscle alpha-actin
分子名称: ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ...
著者Arora, A.S, Huang, H.L, Heissler, S.M, Chinthalapudi, K.
登録日2022-07-08
公開日2023-04-12
実験手法ELECTRON MICROSCOPY (3.37 Å)
主引用文献Structural insights into actin isoforms.
Elife, 12, 2023
8DNH
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BU of 8dnh by Molmil
Cryo-EM structure of nonmuscle beta-actin
分子名称: ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ...
著者Arora, A.S, Huang, H.L, Heissler, S.M, Chinthalapudi, K.
登録日2022-07-11
公開日2023-04-12
実験手法ELECTRON MICROSCOPY (2.99 Å)
主引用文献Structural insights into actin isoforms.
Elife, 12, 2023
2XO8
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BU of 2xo8 by Molmil
Crystal Structure of Myosin-2 in Complex with Tribromodichloropseudilin
分子名称: 2,4-DICHLORO-6-(3,4,5-TRIBROMO-1H-PYRROL-2-YL)PHENOL, ADP METAVANADATE, MAGNESIUM ION, ...
著者Preller, M, Chinthalapudi, K, Martin, R, Knoelker, H.J, Manstein, D.J.
登録日2010-08-10
公開日2011-05-25
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Inhibition of Myosin ATPase Activity by Halogenated Pseudilins: A Structure-Activity Study.
J.Med.Chem., 54, 2011

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