5LI0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5li0 by Molmil](/molmil-images/mine/5li0) | 70S ribosome from Staphylococcus aureus | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Khusainov, I, Vicens, Q, Bochler, A, Grosse, F, Myasnikov, A, Menetret, J.F, Chicher, J, Marzi, S, Romby, P, Yusupova, G, Yusupov, M, Hashem, Y. | 登録日 | 2016-07-13 | 公開日 | 2016-12-28 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structure of the 70S ribosome from human pathogen Staphylococcus aureus. Nucleic Acids Res., 44, 2016
|
|
5LWR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5lwr by Molmil](/molmil-images/mine/5lwr) | Endothiapepsin in complex with a derivative of fragment 177 | 分子名称: | 1,2-ETHANEDIOL, 4-[12-[(1-chloranyl-5,6,7-trimethyl-pyrrolo[3,4-d]pyridazin-3-ium-3-yl)methyl]-10,11-dimethyl-3,4,6,7,11-pentazatricyclo[7.3.0.0^{2,6}]dodeca-1(12),2,4,7,9-pentaen-5-yl]-1,2,5-trimethyl-pyrrole-3-carbaldehyde, ACETATE ION, ... | 著者 | Ehrmann, F.R, Schiebel, J, Heine, A, Klebe, G. | 登録日 | 2016-09-19 | 公開日 | 2017-08-09 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.249 Å) | 主引用文献 | A False-Positive Screening Hit in Fragment-Based Lead Discovery: Watch out for the Red Herring. Angew. Chem. Int. Ed. Engl., 56, 2017
|
|
6KNR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6knr by Molmil](/molmil-images/mine/6knr) | Crystal structure of Estrogen-related receptor gamma ligand-binding domain with DN200699 | 分子名称: | (E)-4-(1-(4-(1-cyclopropylpiperidin-4-yl)phenyl)-5-hydroxy-2-phenylpent-1-en-1-yl)phenol, Estrogen-related receptor gamma | 著者 | Yoon, H, Kim, J, Chin, J, Song, J, Cho, S.J. | 登録日 | 2019-08-07 | 公開日 | 2020-08-12 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.804 Å) | 主引用文献 | An orally available inverse agonist of estrogen-related receptor gamma showed expanded efficacy for the radioiodine therapy of poorly differentiated thyroid cancer. Eur.J.Med.Chem., 205, 2020
|
|
3K6V
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3k6v by Molmil](/molmil-images/mine/3k6v) | M. acetivorans Molybdate-Binding Protein (ModA) in Citrate-Bound Open Form | 分子名称: | CITRIC ACID, Solute-binding protein MA_0280 | 著者 | Chan, S, Giuroiu, I, Chernishof, I, Sawaya, M.R, Chiang, J, Gunsalus, R.P, Arbing, M.A, Perry, L.J. | 登録日 | 2009-10-09 | 公開日 | 2010-01-12 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Apo and ligand-bound structures of ModA from the archaeon Methanosarcina acetivorans Acta Crystallogr.,Sect.F, 66, 2010
|
|
3ZUE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3zue by Molmil](/molmil-images/mine/3zue) | Rabbit Hemorrhagic Disease Virus (RHDV)capsid protein | 分子名称: | CAPSID STRUCTURAL PROTEIN VP60 | 著者 | Luque, D, Gonzalez, J.M, Gomez-Blanco, J, Marabini, R, Chichon, J, Mena, I, Angulo, I, Carrascosa, J.L, Verdaguer, N, Trus, B.L, Barcena, J, Caston, J.R. | 登録日 | 2011-07-18 | 公開日 | 2012-05-23 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (10.3 Å) | 主引用文献 | Epitope Insertion at the N-Terminal Molecular Switch of the Rabbit Hemorrhagic Disease Virus T=3 Capsid Protein Leads to Larger T=4 Capsids. J.Virol., 86, 2012
|
|
2WDU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2wdu by Molmil](/molmil-images/mine/2wdu) | Fasciola hepatica sigma class GST | 分子名称: | BROMIDE ION, DIMETHYL SULFOXIDE, GLUTATHIONE, ... | 著者 | Line, K, Isupov, M.N, LaCourse, E.J, Brophy, P.M, Littlechild, J.A. | 登録日 | 2009-03-26 | 公開日 | 2010-04-21 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | The 1.6 Angstrom Crystal Structure of the Fasciola Hepatica Sigma Class Gst To be Published
|
|
4F1E
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4f1e by Molmil](/molmil-images/mine/4f1e) | The Crystal Structure of a Human MitoNEET mutant with Asp 67 replaced by a Gly | 分子名称: | CDGSH iron-sulfur domain-containing protein 1, FE2/S2 (INORGANIC) CLUSTER | 著者 | Baxter, E.I, Zuris, J.A, Wang, C, Axelrod, H.L, Cohen, A.E, Paddock, M.L, Nechushtai, R, Onuchic, J.N, Jennings, P.A. | 登録日 | 2012-05-06 | 公開日 | 2012-12-26 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Allosteric control in a metalloprotein dramatically alters function. Proc.Natl.Acad.Sci.USA, 110, 2013
|
|
3K6W
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3k6w by Molmil](/molmil-images/mine/3k6w) | Apo and ligand bound structures of ModA from the archaeon Methanosarcina acetivorans | 分子名称: | MOLYBDATE ION, SULFATE ION, Solute-binding protein MA_0280 | 著者 | Chan, S, Chernishof, I, Giuroiu, I, Sawaya, M.R, Chiang, J, Gunsalus, R.P, Arbing, M.A, Perry, L.J. | 登録日 | 2009-10-09 | 公開日 | 2010-01-12 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Apo and ligand-bound structures of ModA from the archaeon Methanosarcina acetivorans Acta Crystallogr.,Sect.F, 66, 2010
|
|
2WB9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2wb9 by Molmil](/molmil-images/mine/2wb9) | Fasciola hepatica sigma class GST | 分子名称: | BROMIDE ION, CYSTEINE, GLUTATHIONE, ... | 著者 | Line, K, Isupov, M.N, LaCourse, J, Brophy, P.M, Littlechild, J.A. | 登録日 | 2009-02-23 | 公開日 | 2010-03-31 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | 主引用文献 | The 1.6 Angstrom Crystal Structure of the Fasciola Hepatica Sigma Class Gst To be Published
|
|
6A6K
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6a6k by Molmil](/molmil-images/mine/6a6k) | Crystal structure of Estrogen-related Receptor-3 (ERR-gamma) ligand binding domain with DN201000 | 分子名称: | 3-[(~{E})-5-oxidanyl-2-phenyl-1-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pent-1-enyl]phenol, Estrogen-related receptor gamma | 著者 | Yoon, H, Kim, J, Chin, J, Cho, S.J, Song, J. | 登録日 | 2018-06-28 | 公開日 | 2019-04-10 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Discovery of Potent, Selective, and Orally Bioavailable Estrogen-Related Receptor-gamma Inverse Agonists To Restore the Sodium Iodide Symporter Function in Anaplastic Thyroid Cancer. J. Med. Chem., 62, 2019
|
|
1P4D
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1p4d by Molmil](/molmil-images/mine/1p4d) | F factor TraI Relaxase Domain | 分子名称: | 1,2-ETHANEDIOL, MAGNESIUM ION, TraI protein | 著者 | Datta, S, Larkin, C, Schildbach, J.F. | 登録日 | 2003-04-22 | 公開日 | 2003-10-14 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural insights into single-stranded DNA binding and cleavage by F factor TraI. Structure, 11, 2003
|
|
2X53
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2x53 by Molmil](/molmil-images/mine/2x53) | Structure of the phage p2 baseplate in its activated conformation with Sr | 分子名称: | ORF15, ORF16, PUTATIVE RECEPTOR BINDING PROTEIN, ... | 著者 | Sciara, G, Bebeacua, C, Bron, P, Tremblay, D, Ortiz-Lombardia, M, Lichiere, J, van Heel, M, Campanacci, V, Moineau, S, Cambillau, C. | 登録日 | 2010-02-05 | 公開日 | 2010-02-16 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.9 Å) | 主引用文献 | Structure of Lactococcal Phage P2 Baseplate and its Mechanism of Activation. Proc.Natl.Acad.Sci.USA, 107, 2010
|
|
1ONV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1onv by Molmil](/molmil-images/mine/1onv) | NMR Structure of a Complex Containing the TFIIF Subunit RAP74 and the RNAP II CTD Phosphatase FCP1 | 分子名称: | Transcription initiation factor IIF, alpha subunit, serine phosphatase FCP1a | 著者 | Nguyen, B.D, Abbott, K.L, Potempa, K, Kobor, M.S, Archambault, J, Greenblatt, J, Legault, P, Omichinski, J.G. | 登録日 | 2003-03-02 | 公開日 | 2003-05-20 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR Structure of a Complex Containing the TFIIF Subunit RAP74 and the RNA polymerase II carboxyl-terminal domain phosphatase FCP1 Proc.Natl.Acad.Sci.USA, 100, 2003
|
|
4EHK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4ehk by Molmil](/molmil-images/mine/4ehk) | Allosteric Modulation of Caspase-3 through Mutagenesis | 分子名称: | ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, Caspase-3 | 著者 | Walters, J, Schipper, J.L, Swartz, P.D, Mattos, C, Clark, A.C. | 登録日 | 2012-04-02 | 公開日 | 2012-06-06 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (1.668 Å) | 主引用文献 | Allosteric modulation of caspase 3 through mutagenesis. Biosci.Rep., 32, 2012
|
|
1B7G
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1b7g by Molmil](/molmil-images/mine/1b7g) | GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE | 分子名称: | PROTEIN (GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE), SULFATE ION | 著者 | Isupov, M.N, Littlechild, J.A. | 登録日 | 1999-01-22 | 公開日 | 1999-10-08 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Crystal structure of the glyceraldehyde-3-phosphate dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus. J.Mol.Biol., 291, 1999
|
|
6ECD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ecd by Molmil](/molmil-images/mine/6ecd) | Vlm2 thioesterase domain with genetically encoded 2,3-diaminopropionic acid bound with a tetradepsipeptide | 分子名称: | Vlm2, tetradepsipeptide | 著者 | Alonzo, D.A, Huguenin-Dezot, N, Heberlig, G.W, Mahesh, M, Nguyen, D.P, Dornan, M.H, Boddy, C.N, Chin, J.W, Schmeing, T.M. | 登録日 | 2018-08-07 | 公開日 | 2018-12-12 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Trapping biosynthetic acyl-enzyme intermediates with encoded 2,3-diaminopropionic acid. Nature, 565, 2019
|
|
4EZF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4ezf by Molmil](/molmil-images/mine/4ezf) | The Crystal Structure of a Human MitoNEET mutant with an Ala inserted between Asp 67 and Lys 68 | 分子名称: | CDGSH iron-sulfur domain-containing protein 1, FE2/S2 (INORGANIC) CLUSTER | 著者 | Baxter, E.L, Zuris, J.A, Wang, C, Axelrod, H.L, Cohen, A.E, Paddock, M.L, Nechushtai, R, Onuchic, J.N, Jennings, P.A. | 登録日 | 2012-05-02 | 公開日 | 2012-12-26 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.19 Å) | 主引用文献 | Allosteric control in a metalloprotein dramatically alters function. Proc.Natl.Acad.Sci.USA, 110, 2013
|
|
3U6X
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3u6x by Molmil](/molmil-images/mine/3u6x) | Phage TP901-1 baseplate tripod | 分子名称: | BPP, BROMIDE ION, ORF48 | 著者 | Veesler, D, Spinelli, S, Mahony, J, Lichiere, J, Blangy, S, Bricogne, G, Legrand, P, Ortiz-Lombardia, M, Campanacci, V.I, van Sinderen, D, Cambillau, C. | 登録日 | 2011-10-13 | 公開日 | 2012-07-04 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure of the phage TP901-1 1.8 MDa baseplate suggests an alternative host adhesion mechanism. Proc.Natl.Acad.Sci.USA, 109, 2012
|
|
7ADG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7adg by Molmil](/molmil-images/mine/7adg) | Cocktail experiment G: fragments 216 and 338 at 90 mM concentration in complex with Endothiapepsin | 分子名称: | 2-(1H-imidazol-1-yl)-N-(trans-4-methylcyclohexyl)acetamide, ACETATE ION, DIMETHYL SULFOXIDE, ... | 著者 | Hassaan, E, Klebe, G, Heine, A, Schiebel, J, Koester, H. | 登録日 | 2020-09-14 | 公開日 | 2021-10-06 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.0794636 Å) | 主引用文献 | Comparison of Cocktail Screening in X-Ray Crystallography vs NMR To Be Published
|
|
7DN2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7dn2 by Molmil](/molmil-images/mine/7dn2) | Acidic stable capsid structure of Helicobacter pylori bacteriophage KHP30 | 分子名称: | Cement protein gp15, Major structural protein ORF14 | 著者 | Kamiya, R, Uchiyama, J, Matsuzaki, S, Murata, K, Iwasaki, K, Miyazaki, N. | 登録日 | 2020-12-08 | 公開日 | 2021-10-27 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Acid-stable capsid structure of Helicobacter pylori bacteriophage KHP30 by single-particle cryoelectron microscopy. Structure, 30, 2022
|
|
6ECE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ece by Molmil](/molmil-images/mine/6ece) | Vlm2 thioesterase domain with genetically encoded 2,3-diaminopropionic acid bound with a dodecadepsipeptide, space group H3 | 分子名称: | Vlm2, dodecadepsipeptide | 著者 | Alonzo, D.A, Huguenin-Dezot, N, Heberlig, G.W, Mahesh, M, Nguyen, D.P, Dornan, M.H, Boddy, C.N, Chin, J.W, Schmeing, T.M. | 登録日 | 2018-08-07 | 公開日 | 2018-12-12 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Trapping biosynthetic acyl-enzyme intermediates with encoded 2,3-diaminopropionic acid. Nature, 565, 2019
|
|
1NHA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1nha by Molmil](/molmil-images/mine/1nha) | Solution Structure of the Carboxyl-Terminal Domain of RAP74 and NMR Characterization of the FCP-Binding Sites of RAP74 and CTD of RAP74, the subunit of Human TFIIF | 分子名称: | Transcription initiation factor IIF, alpha subunit | 著者 | Nguyen, B.D, Chen, H.T, Kobor, M.S, Greenblatt, J, Legault, P, Omichinski, J.G. | 登録日 | 2002-12-19 | 公開日 | 2003-02-25 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution Structure of the Carboxyl-Terminal Domain of RAP74 and NMR Characterization of the FCP1-Binding Sites of RAP74 and Human TFIIB. Biochemistry, 42, 2003
|
|
4GAI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4gai by Molmil](/molmil-images/mine/4gai) | Crystal structure of EBI-005, a chimera of human IL-1beta and IL-1Ra | 分子名称: | EBI-005 | 著者 | Hou, J, Townson, S.A, Kovalchin, J.T, Masci, A, Kiner, O, Shu, Y, King, B, Thomas, C, Garcia, K.C, Furfine, E.S, Barnes, T.M. | 登録日 | 2012-07-25 | 公開日 | 2013-02-20 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | Design of a superior cytokine antagonist for topical ophthalmic use. Proc.Natl.Acad.Sci.USA, 110, 2013
|
|
5Y7X
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5y7x by Molmil](/molmil-images/mine/5y7x) | Human Peroxisome proliferator-activated receptor (PPAR) delta in complexed with a potent and selective agonist | 分子名称: | 2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-selenazol-5-yl]methylsulfanyl]phenoxy]ethanoic acid, CHLORIDE ION, POTASSIUM ION, ... | 著者 | Kim, H.L, Chin, J.W, Cho, S.J, Song, J.Y, Yoon, H.S, Bae, J.H. | 登録日 | 2017-08-18 | 公開日 | 2018-08-01 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.699 Å) | 主引用文献 | Design, synthesis, and the X-ray co-crystal structure of Highly Potent, Selective, and Orally Bioavailable, Novel Peroxisome Proliferator-Activated Receptor delta Agonists To Be Published
|
|
2MBH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2mbh by Molmil](/molmil-images/mine/2mbh) | |