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6ECE

Vlm2 thioesterase domain with genetically encoded 2,3-diaminopropionic acid bound with a dodecadepsipeptide, space group H3

Summary for 6ECE
Entry DOI10.2210/pdb6ece/pdb
Related6ECB 6ECC 6ECD 6ECF
DescriptorVlm2, dodecadepsipeptide (3 entities in total)
Functional Keywordsthioesterase, thioesterase domain, nrps, non-ribosomal peptide synthetase, nonribosomal peptide synthetase, valinomycin, hydrolase, depsipeptide, unnatural amino acid, 2, 3-diaminopropionic acid
Biological sourceStreptomyces tsusimaensis
More
Total number of polymer chains4
Total formula weight68449.70
Authors
Alonzo, D.A.,Huguenin-Dezot, N.,Heberlig, G.W.,Mahesh, M.,Nguyen, D.P.,Dornan, M.H.,Boddy, C.N.,Chin, J.W.,Schmeing, T.M. (deposition date: 2018-08-07, release date: 2018-12-12, Last modification date: 2023-11-15)
Primary citationHuguenin-Dezot, N.,Alonzo, D.A.,Heberlig, G.W.,Mahesh, M.,Nguyen, D.P.,Dornan, M.H.,Boddy, C.N.,Schmeing, T.M.,Chin, J.W.
Trapping biosynthetic acyl-enzyme intermediates with encoded 2,3-diaminopropionic acid.
Nature, 565:112-117, 2019
Cited by
PubMed: 30542153
DOI: 10.1038/s41586-018-0781-z
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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