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PDB: 46 件
8JTS
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BU of 8jts by Molmil
hOCT1 in complex with metformin in outward open conformation
分子名称: Metformin, Solute carrier family 22 member 1
著者Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X.
登録日2023-06-22
公開日2024-03-27
実験手法ELECTRON MICROSCOPY (4.14 Å)
主引用文献Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
8JTY
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BU of 8jty by Molmil
hOCT1 in complex with nb5660 in inward facing partially open 2 conformation
分子名称: Solute carrier family 22 member 1, nanobody 56
著者Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X.
登録日2023-06-22
公開日2024-03-27
実験手法ELECTRON MICROSCOPY (3.26 Å)
主引用文献Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
8JTT
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BU of 8jtt by Molmil
hOCT1 in complex with metformin in outward occluded conformation
分子名称: Metformin, Solute carrier family 22 member 1
著者Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X.
登録日2023-06-22
公開日2024-03-27
実験手法ELECTRON MICROSCOPY (3.87 Å)
主引用文献Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
8JTX
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BU of 8jtx by Molmil
hOCT1 in complex with nb5660 in inward facing fully open conformation
分子名称: Solute carrier family 22 member 1, nanobody 56
著者Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X.
登録日2023-06-22
公開日2024-03-27
実験手法ELECTRON MICROSCOPY (3.28 Å)
主引用文献Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
8JU0
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BU of 8ju0 by Molmil
hOCT1 in complex with spironolactone in inward facing occluded conformation
分子名称: SPIRONOLACTONE, Solute carrier family 22 member 1
著者Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X.
登録日2023-06-23
公開日2024-03-27
実験手法ELECTRON MICROSCOPY (2.98 Å)
主引用文献Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
8JTV
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BU of 8jtv by Molmil
hOCT1 in complex with metformin in inward occluded conformation
分子名称: Metformin, Solute carrier family 22 member 1
著者Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X.
登録日2023-06-22
公開日2024-03-27
実験手法ELECTRON MICROSCOPY (3.77 Å)
主引用文献Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
8JTW
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BU of 8jtw by Molmil
hOCT1 in complex with nb5660 in inward facing partially open 1 conformation
分子名称: Solute carrier family 22 member 1, nanobody 56
著者Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X.
登録日2023-06-22
公開日2024-03-27
実験手法ELECTRON MICROSCOPY (3.23 Å)
主引用文献Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
8JTZ
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BU of 8jtz by Molmil
hOCT1 in complex with spironolactone in outward facing partially occluded conformation
分子名称: SPIRONOLACTONE, Solute carrier family 22 member 1
著者Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X.
登録日2023-06-22
公開日2024-03-27
実験手法ELECTRON MICROSCOPY (3.27 Å)
主引用文献Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
3JA4
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BU of 3ja4 by Molmil
RNA-dependent RNA polymerases of transcribing cypoviruses
分子名称: RNA-dependent RNA polymerase
著者Liu, H, Cheng, L.
登録日2015-04-20
公開日2015-10-28
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (4.8 Å)
主引用文献Cryo-EM shows the polymerase structures and a nonspooled genome within a dsRNA virus.
Science, 349, 2015
3J6Q
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BU of 3j6q by Molmil
Identification of the active sites in the methyltransferases of a transcribing dsRNA virus
分子名称: S-ADENOSYL-L-HOMOCYSTEINE, Structural protein VP3
著者Zhu, B, Yang, C, Liu, H, Cheng, L, Song, F, Zeng, S, Huang, X, Ji, G, Zhu, P.
登録日2014-03-20
公開日2014-10-08
最終更新日2019-12-18
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Identification of the active sites in the methyltransferases of a transcribing dsRNA virus.
J.Mol.Biol., 426, 2014
3J17
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BU of 3j17 by Molmil
Structure of a transcribing cypovirus by cryo-electron microscopy
分子名称: Structural protein VP3, Structural protein VP5, VP1
著者Yang, C, Ji, G, Liu, H, Zhang, K, Liu, G, Sun, F, Zhu, P, Cheng, L.
登録日2011-12-25
公開日2012-04-04
最終更新日2018-07-18
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Cryo-EM structure of a transcribing cypovirus.
Proc.Natl.Acad.Sci.USA, 109, 2012
3JA5
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BU of 3ja5 by Molmil
Genome and RdRp structure within the capsid of no-transcribing cypovirus
分子名称: RNA-dependent RNA polymerase
著者Liu, H, Cheng, L.
登録日2015-04-21
公開日2015-10-28
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (12 Å)
主引用文献Cryo-EM shows the polymerase structures and a nonspooled genome within a dsRNA virus.
Science, 349, 2015
8JII
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BU of 8jii by Molmil
Cryo-EM structure of compound 9n and niacin bound ketone body receptor HCAR2-Gi signaling complex
分子名称: 7-methyl-N-[(2R)-1-phenoxypropan-2-yl]-3-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Zhao, C, Tian, X.W, Liu, Y, Cheng, L, Yan, W, Shao, Z.H.
登録日2023-05-26
公開日2023-09-06
最終更新日2023-09-27
実験手法ELECTRON MICROSCOPY (3.17 Å)
主引用文献Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation.
Mol.Cell, 83, 2023
8JIM
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BU of 8jim by Molmil
Cryo-EM structure of MMF bound ketone body receptor HCAR2-Gi signaling complex
分子名称: (2Z)-4-methoxy-4-oxobut-2-enoic acid, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Zhao, C, Tian, X.W, Liu, Y, Cheng, L, Yan, W, Shao, Z.H.
登録日2023-05-26
公開日2023-09-06
最終更新日2023-09-27
実験手法ELECTRON MICROSCOPY (2.98 Å)
主引用文献Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation.
Mol.Cell, 83, 2023
8JHY
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BU of 8jhy by Molmil
Cryo-EM structure of compound 9n bound ketone body receptor HCAR2-Gi signaling complex
分子名称: 7-methyl-N-[(2R)-1-phenoxypropan-2-yl]-3-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Zhao, C, Tian, X.W, Liu, Y, Cheng, L, Yan, W, Shao, Z.H.
登録日2023-05-25
公開日2023-09-06
最終更新日2023-09-27
実験手法ELECTRON MICROSCOPY (2.87 Å)
主引用文献Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation.
Mol.Cell, 83, 2023
8JIL
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BU of 8jil by Molmil
Cryo-EM structure of niacin bound ketone body receptor HCAR2-Gi signaling complex
分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Zhao, C, Tian, X.W, Liu, Y, Cheng, L, Yan, W, Shao, Z.H.
登録日2023-05-26
公開日2023-09-06
最終更新日2023-09-27
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation.
Mol.Cell, 83, 2023
5ZVS
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BU of 5zvs by Molmil
Structure of RNA polymerase complex and genome within a dsRNA virus provides insights into the mechanisms of transcription and assembly
分子名称: Putative core protein NTPase/VP5, VP2, VP3
著者Liu, H, Fang, Q, Cheng, L.
登録日2018-05-12
公開日2018-07-04
最終更新日2018-07-25
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Structure of RNA polymerase complex and genome within a dsRNA virus provides insights into the mechanisms of transcription and assembly.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5ZVT
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BU of 5zvt by Molmil
Structure of RNA polymerase complex and genome within a dsRNA virus provides insights into the mechanisms of transcription and assembly
分子名称: C-terminus of outer capsid protein VP5, Core protein VP6, MYRISTIC ACID, ...
著者Liu, H, Fang, Q, Cheng, L.
登録日2018-05-12
公開日2018-07-04
最終更新日2018-07-25
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structure of RNA polymerase complex and genome within a dsRNA virus provides insights into the mechanisms of transcription and assembly.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
8JZ7
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BU of 8jz7 by Molmil
Cryo-EM structure of MK-6892-bound HCAR2 in complex with Gi protein
分子名称: 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Zhao, C, Tian, X.W, Liu, Y, Cheng, L, Yan, W, Shao, Z.H.
登録日2023-07-04
公開日2023-10-04
実験手法ELECTRON MICROSCOPY (2.6 Å)
主引用文献Orthosteric ligand selectivity and allosteric probe dependence at Hydroxycarboxylic acid receptor HCAR2.
Signal Transduct Target Ther, 8, 2023
5GON
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BU of 5gon by Molmil
Structures of a beta-lactam bridged analogue in complex with tubulin
分子名称: (3R,4R)-4-(4-methoxy-3-oxidanyl-phenyl)-3-methyl-1-(3,4,5-trimethoxyphenyl)azetidin-2-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ...
著者Zhou, L, Liu, Y, Cheng, L, Wang, Y.
登録日2016-07-28
公開日2017-03-22
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献Potent Antitumor Activities and Structure Basis of the Chiral beta-Lactam Bridged Analogue of Combretastatin A-4 Binding to Tubulin.
J. Med. Chem., 59, 2016
7EAV
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BU of 7eav by Molmil
The X-ray crystallographic structure of glycogen debranching enzyme from Sulfolobus solfataricus STB09
分子名称: Glycogen debranching enzyme
著者Li, Z.F, Ban, X.F, Tian, Y.X, Li, C.M, Cheng, L, Hong, Y, Gu, Z.B.
登録日2021-03-08
公開日2022-03-09
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.803 Å)
主引用文献The X-ray Crystallographic Structure of Debranching Enzyme from Sulfolobus solfataricus STB09
To Be Published
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