7YDS

The structure of the bispecific antibody targeted PD-L1 and 4-1BB

Summary for 7YDS

Entry DOI	10.2210/pdb7yds/pdb
Descriptor	Programmed cell death 1 ligand 1, Anti-PDL1-VH-CH1, Anti-PDL1-VL-CL, ... (4 entities in total)
Functional Keywords	complex, checkpoint inhibitors, immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	64192.13
Authors	Gao, Y.,Zhu, M.,Liu, W.T.,Cheng, L.S.,Zhu, Z.L.,Niu, L.W. (deposition date: 2022-07-04, release date: 2023-07-19, Last modification date: 2023-11-29)
Primary citation	Zhu, M.,Gao, Y. A bispecific antibody targeted PD-L1 and 4-1BB induces a potent antitumor immune activity in colorectal cancer without systemic toxicity To Be Published,
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation